A5100340131- Cancer Cells and Metastasis
- Pancreatic and Hepatic Oncology Research
- Epigenetics and DNA Methylation
- Cancer-related Molecular Pathways
- Hippo pathway signaling and YAP/TAZ
- RNA modifications and cancer
- Cancer Treatment and Pharmacology
- Chemokine receptors and signaling
- HER2/EGFR in Cancer Research
- Monoclonal and Polyclonal Antibodies Research
- Ferroptosis and cancer prognosis
- Wnt/β-catenin signaling in development and cancer
- Schizophrenia research and treatment
- Cancer, Hypoxia, and Metabolism
- Microtubule and mitosis dynamics
- Cancer Research and Treatments
- Drug Transport and Resistance Mechanisms
- Lymphatic System and Diseases
- Cancer Immunotherapy and Biomarkers
- Cytokine Signaling Pathways and Interactions
- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
- Blood Coagulation and Thrombosis Mechanisms
- Genetic Associations and Epidemiology
- Obstructive Sleep Apnea Research
Fujian Normal University
2024
Tongji University
2023
Shanghai Skin Disease Hospital
2023
Wuhan University
2023
Renmin Hospital of Wuhan University
2023
Capital Medical University
2010-2022
SleepMed
2022
Ningxia University
2022
First Affiliated Hospital of Wenzhou Medical University
2022
Third Affiliated Hospital of Zhengzhou University
2022
Abstract Purpose: Besides its therapeutic effects, chemotherapeutic agents also enhance the malignancy of treated cancers in clinical situations. Recently, epithelial-mesenchymal transition (EMT) has attracted attention studies tumor progression. We aimed to test whether transient Adriamycin treatment induces EMT and apoptosis simultaneously cancer cells, clarify why same type cells responds differentially (i.e., apoptosis, EMT) treatment, elucidate role Twist1, master regulator EMT, this...
<h3>Importance</h3> Socioeconomic variables including sex, race, ethnicity, marital status, and insurance status are associated with survival in pancreatic cancer. It remains unknown exactly how these influence survival, whether they affect stage at presentation or receipt of treatment independently outcomes. <h3>Objectives</h3> To investigate the relationship between socioeconomic factors odds resection early-stage, resectable adenocarcinoma to determine same were patients who underwent...
Epithelial-to-mesenchymal transition (EMT) plays a pivotal role in lung cancer metastasis. The class III deacetylase sirtuin 1 (SIRT1) possesses both pro- and anticarcinogenic properties. of SIRT1 EMT is largely undefined.The effect on migration cells was evaluated by wound healing assay vitro metastasis nude mice vivo. Protein expression human cancers cultured assessed western blotting immunohistochemistry. Interaction between protein DNA measured chromatin immunoprecipitation assay....
Abstract Purpose This investigation sought to examine the efficacy and safety of low-dose apatinib used alongside chemotherapy in clinical management patients with metastatic triple-negative breast cancer (TNBC) within a real-world setting, whilst comparing outcomes those treated solely chemotherapy. Methods case series study analyzed data treatment 163 TNBC who underwent rescue at Medical Oncology Department Clinical Oncology, Fujian Cancer Hospital, School University, China, between...
Abstract Background Ovarian cancer was one of the leading causes female deaths. Patients with OC were essentially incurable and portends a poor prognosis, presumably because profound genetic heterogeneity limiting reproducible prognostic classifications. Methods We comprehensively analyzed an ovarian single-cell RNA sequencing dataset, GSE118828, identified nine major cell types. Relationship between clusters explored CellPhoneDB. A malignant epithelial cluster confirmed using pseudotime...
Special AT-rich sequence binding protein (SATB) 1 has been proposed to act as a determinant for the acquisition of metastatic activity by controlling expression specific set genes that promote activity. Here we found SATB1 is upregulated in multidrug-resistant breast cancer cells exhibit higher invasive potential than parental cells. Apart from accelerating metastasis and inducing epithelial-mesenchymal transition, was demonstrated confer resistance both P-glycoprotein-related...
Microvascular insufficiency takes a critical role in the development of diabetic cardiomyopathy (DCM). So this study was designed to investigate effects Neuregulin-1 (NRG-1) treatment on myocardial angiogenesis and changes VEGF/Flk1 Ang-1/Tie-2 signaling rat model DCM.Diabetic rats were induced by single intraperitoneal injection Streptozotocin. 12 weeks after diabetes induction, with NRG-1 treated tail vein at dose 10µg/kg/d for consecutive 10 days. Cardiac function assessed using catheter...
Abstract Chloride channel‐3 (ClC‐3), a member of the ClC family voltage‐gated Cl − channels, is involved in resistance tumor cells to chemotherapeutic drugs. Here, we report new mechanism for ClC‐3 mediating multidrug (MDR). was highly expressed P‐glycoprotein (P‐gp)‐dependent human lung adenocarcinoma cell line (A549)/paclitaxel (PTX) and breast carcinoma (MCF‐7)/doxorubicin (DOX) resistant cells. Changes expression resulted development drug formerly drug‐sensitive A549 or MCF‐7 cells,...
Ovarian cancer (OC) is one of the leading causes female deaths. However, molecular pathogenesis OC has still remained elusive. This study aimed to explore potential genes associated with progression OC. In current study, 3 data sets were downloaded from GEO database identify hub gene. Somatic mutation obtained TCGA used analyse mutation. Immune cells estimate effect gene tumour microenvironment. RNA-seq and clinical patients retrieved investigate diagnostic prognostic values A series in...
The di-leucine motif exists in the intracellular domains of certain cell surface receptors, participating receptor-mediated endocytosis. present study was aimed at determining role class A scavenger receptor (SR-A)-mediated ligand endocytosis.cDNA coding for a mutant (SR-A N3132LM) with deletion structure transfected into Chinese hamster ovary (CHO) cells. Compared wild-type SR-A-expressing cells, cells expressing SR-A N3132LM showed significant decrease uptake but almost no change binding...
Background Pancreatic cancer has an enrichment of stem-like cells (CSCs) that contribute to chemoresistant tumors prone metastasis and recurrence. Drug screening assays based on cytotoxicity cannot identify specific CSC inhibitors, because CSCs comprise only a small portion cell population, it is difficult propagate stable populations in vitro for high-throughput (HTS) assays. Based the important role epithelial-to-mesenchymal transition (EMT) promoting CSCs, we hypothesized inhibition EMT...
Keratin 23 (KRT23) is a new member of the KRT gene family and known to be involved in development migration various types tumors. However, role KRT23 ovarian cancer (OC) remains unclear. This study aimed at investigating function OC.The expression normal OC tissues was determined using Oncomine database immunohistochemical staining. Reverse transcription quantitative polymerase chain reaction assay used analyze epithelial cell lines lines. Small interfering RNA (siRNA), wound healing assay,...
Uncontrolled cell division is one of the hallmarks tumor growth. Researches have been focused on numerous molecules involved in this process. Cyclins are critical regulatory proteins cycle progression and/or transcription. The present study aimed to investigate anti-proliferative effect cyclin L2, and define its growth mechanisms using human lung adenocarcinoma line A549.Human L2 was transfected into cells (A549 cell), expressed a mammalian expression vector pcDNA3.1. effects growth,...