A5102860680- Schizophrenia research and treatment
- Functional Brain Connectivity Studies
- Anatomy and Medical Technology
- Tryptophan and brain disorders
- Medical Imaging and Analysis
- Global Trade and Competitiveness
- Genetic Associations and Epidemiology
- Alzheimer's disease research and treatments
- Advanced MRI Techniques and Applications
- Family Caregiving in Mental Illness
- Advanced Neuroimaging Techniques and Applications
- Neural dynamics and brain function
- International Business and FDI
- Mitochondrial Function and Pathology
- Global trade and economics
- Genetics and Neurodevelopmental Disorders
- Neuroscience and Music Perception
- Medical Image Segmentation Techniques
- Neuroscience and Neuropharmacology Research
- Metabolism and Genetic Disorders
- Mental Health Research Topics
- Metabolomics and Mass Spectrometry Studies
- Facial Nerve Paralysis Treatment and Research
- Simulation and Modeling Applications
- Sleep and Wakefulness Research
Central South University
2014-2024
Second Xiangya Hospital of Central South University
2014-2024
Children's Hospital of Chongqing Medical University
2022-2023
Chongqing Medical University
2022-2023
China International Science and Technology Cooperation
2022-2023
Shandong University
2022
Army Medical University
2003-2016
Wuhan University
2005-2012
Institute of Economics
2011
Alzheimer's disease is the most common neurodegenerative disease, and has a high level of genetic heritability population heterogeneity. In this study, we performed whole-exome sequencing Han Chinese patients with familial and/or early-onset followed by independent validation, imaging analysis function characterization. We identified an exome-wide significant rare missense variant rs3792646 (p.K420Q) in C7 gene discovery stage (P = 1.09 × 10-6, odds ratio 7.853) confirmed association...
Schizophrenia is a severe mental illness associated with the symptoms such as hallucination and delusion. The objective of this study was to investigate abnormal resting-state functional connectivity patterns schizophrenic patients which could identify furthest from healthy controls. whole-brain fMRI performed on diagnosed schizophrenia (n = 22) age- gender-matched, control subjects 22). To differentiate individuals controls, multivariate classification analysis employed. weighted brain...
Background Major depressive disorder (MDD) is the leading cause of disability worldwide, and has significant genetic predisposition. Mitochondria may have a role in MDD so mitochondrial DNA (mtDNA) been suggested as possible biomarker for this disease. We aimed to test whether mtDNA copy number peripheral blood leukocytes related young adults. Methods A case-control study was conducted with 210 patients 217 healthy controls (HC). The measured by quantitative polymerase chain reaction (qPCR)...
Abstract Background Neuroinflammatory factors, especially chemokines, have been widely reported to be involved in the pathogenesis of Alzheimer’s disease (AD). It is unclear how chemokines are altered AD, and whether dysregulation cause, or consequence, disease. Methods We initially screened transcriptomic profiles from publicly available datasets brain tissues AD patients mouse models. Expression alteration blood was also measured explore any chemokine might used as a potential biomarker...
Background Loss of gray matter has been previously found in early-onset schizophrenic patients. However, there are no consistent findings between studies due to different methods used measure grey volume/density and influences confounding factors. Methods The volume (GM) was measured 29 first episode schizophrenia (EOS) 34 well-matched healthy controls by using voxel-based morphometry (VBM). Psychotic symptoms were assessed the Positive Negative Syndrome Scale (PANSS). correlations GM PANSS...
The underlying mechanism for individual differences in patient response to antipsychotic medication remains unknown.To discover genes and gene sets harboring rare variants associated with short-term efficacy.In this multicenter, open-label, randomized clinical trial conducted between July 6, 2010, December 31, 2011, 3023 patients recruited China of Chinese Han descent schizophrenia total Positive Negative Syndrome Scale (PANSS) score ≥ 60 received a 6-week treatment medications randomly...
To compare longitudinal metabolic effects of 7 antipsychotics, including body mass index (BMI), waist circumference (WC), blood pressure (BP), glucose, triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density (LDL-C); to investigate risk factors for syndrome (MetS); make recommendations on frequency timing monitoring measurements.This randomized, open-label, pharmacologic trial was conducted among patients with schizophrenia (DSM-IV) in 32 hospitals across China....
Background Although a number of proteins and genes relevant to schizophrenia have been identified in recent years, few are known about the exact metabolic pathway involved this disease. Our previous proteomic study has revealed energy metabolism abnormality subchronic MK-801 treated rat, well-established animal model for schizophrenia. This prompted us further investigate metabolite levels same rat better delineate dysfunctions provide insights into pathology Methods Metabolomics,...
Saponins extracted from Panax notoginseng leaves by methanol or water could be orally administrated for insomnia with very low bioavailability, which might bio-converted gut microbiota to generate potential bioactive products. Moreover, profiles insomniac patients are different healthy subjects. We aimed compare the metabolic characteristics and of two saponins extract incubation patients. The ginsenosides, notoginsenosides, metabolites were identified relatively quantified high-performance...
Among individuals diagnosed with schizophrenia, approximately 20%-33% are recognized as treatment-resistant schizophrenia (TRS) patients. These TRS patients suffer more severely from the disease but struggle to benefit existing antipsychotic treatments. A few recent studies suggested that may be caused by impaired synaptic plasticity manifests functional dysconnectivity in brain, however, of those focused on connectivity changes brains groups. In this study, we compared whole brain...
Microstate analysis is a powerful tool to probe the brain functions, and changes in microstates under electroencephalography (EEG) have been repeatedly reported patients with schizophrenia. This study aimed investigate dynamics of EEG drug-naïve, first-episode schizophrenia (FE-SCH) test relationship between clinical symptoms.Resting-state were recorded for 23 FE-SCH healthy controls using 64-channel cap. Three parameters, i.e., contribution, duration, occurrence, four microstate classes...
Objective: Auditory verbal hallucinations (AVH), with unclear mechanisms, cause extreme distresses to schizophrenia patients. Deficits of inhibitory top-down control may be linked AVH. Therefore, in this study, we focused on patients Method: The present study recruited 40 patients, including 20 AVH and non-AVH 23 healthy controls. We employed event-related potentials investigate the N2 P3 amplitude latency differences among these participants during a Go/NoGo task. Results: Relative...
Although several underlying etiologic implications for schizophrenia (SZ) have been proposed, the cross talk between them is rarely explored systematically. The aim of present study was to illustrate pathogenic mechanism SZ through describing a systematical pathophysiology network using proteomic signatures in first-episode patients. A total 3152 proteins were identified leukocytes, and 475 these significantly altered SZ. Functional analysis revealed that cell redox homeostasis dramatically...