A5068466030- Seed and Plant Biochemistry
- interferon and immune responses
- Plant Molecular Biology Research
- Genomics and Phylogenetic Studies
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Alzheimer's disease research and treatments
- Gut microbiota and health
- Mycobacterium research and diagnosis
- Immune Response and Inflammation
- Cancer-related gene regulation
- Genetic Associations and Epidemiology
- GABA and Rice Research
- RNA Research and Splicing
- Biofuel production and bioconversion
- Chromosomal and Genetic Variations
- Renal Transplantation Outcomes and Treatments
- Viral Infections and Vectors
- Leprosy Research and Treatment
- Functional Brain Connectivity Studies
- Schizophrenia research and treatment
- Photosynthetic Processes and Mechanisms
- Bat Biology and Ecology Studies
- Cancer-related molecular mechanisms research
- Plant nutrient uptake and metabolism
Ministry of Agriculture and Rural Affairs
2023-2025
Chengdu University
2022-2025
Icahn School of Medicine at Mount Sinai
2022-2025
Kunming Institute of Zoology
2013-2024
Tianjin Medical University General Hospital
2024
University of Chinese Academy of Sciences
2014-2024
Chinese Academy of Sciences
2014-2024
Peking University
2022-2024
University of Hong Kong
2021-2024
Suzhou Guangji Hospital
2022-2024
Birds are the most species-rich class of tetrapod vertebrates and have wide relevance across many research fields. We explored bird macroevolution using full genomes from 48 avian species representing all major extant clades. The genome is principally characterized by its constrained size, which predominantly arose because lineage-specific erosion repetitive elements, large segmental deletions, gene loss. Avian furthermore show a remarkably high degree evolutionary stasis at levels...
Chinese tree shrews (Tupaia belangeri chinensis) possess many features valuable in animals used as experimental models biomedical research. Currently, there are numerous attempts to employ for a variety of human disorders: depression, myopia, hepatitis B and C virus infections, hepatocellular carcinoma, name few. Here we present publicly available annotated genome sequence the shrew. Phylogenomic analysis shrew other mammalians highly support its close affinity primates. By characterizing...
Alzheimer disease (AD) is the most common neurodegenerative disease. An imbalance between production and clearance of Aβ (amyloid beta) considered to be actively involved in AD pathogenesis. Macroautophagy/autophagy a major cellular pathway leading removal aggregated proteins, upregulation autophagy represents plausible therapeutic strategy combat overproduction neurotoxic Aβ. PPARA/PPARα (peroxisome proliferator activated receptor alpha) transcription factor that regulates genes fatty acid...
The discovery of N
Abstract Background The GRAS transcription factor family plays a crucial role in various biological processes different plants, such as tissue development, fruit maturation, and environmental stress. However, the rye has not been systematically analyzed yet. Results In this study, 67 genes S. cereale were identified named based on chromosomal location. gene structures, conserved motifs, cis-acting elements, replications, expression patterns further analyzed. These ScGRAS members are divided...
The function of the RIG-I-like receptors (RLRs; including RIG-I, MDA5, and LGP2) as key cytoplasmic sensors viral pathogen-associated molecular patterns (PAMPs) has been subjected to numerous pathogenic challenges undergone a dynamic evolution. We found evolutionary evidence that RIG-I was lost in Chinese tree shrew lineage. Along with loss both MDA5 (tMDA5) LGP2 (tLGP2) have strong positive selection shrew. tMDA5 or tMDA5/tLGP2 could sense Sendai virus (an RNA posed agonist) for inducing...
The aim was to assess the clinical, laboratory and radiological features of SAPHO syndrome.We recruited all patients presenting Peking Union Medical College Hospital from 2004 2015 diagnosed with syndrome. medical data, test results imaging were collected for patients.One hundred sixty-four (111 women 53 men) our cohort. mean age 40.71 years. Nine had osteoarticular symptoms without skin involvement. One forty-three 25 palmoplantar pustulosis severe acne, respectively. Psoriasis vulgaris...
Alzheimer's disease is the most common neurodegenerative disease, and has a high level of genetic heritability population heterogeneity. In this study, we performed whole-exome sequencing Han Chinese patients with familial and/or early-onset followed by independent validation, imaging analysis function characterization. We identified an exome-wide significant rare missense variant rs3792646 (p.K420Q) in C7 gene discovery stage (P = 1.09 × 10-6, odds ratio 7.853) confirmed association...
Chinese tree shrews (Tupaia belangeri chinensis) have become an increasingly important experimental animal in biomedical research due to their close relationship primates. An accurately sequenced and assembled genome is essential for understanding the genetic features biology of this animal. In study, we used long-read single-molecule sequencing high-throughput chromosome conformation capture (Hi-C) technology obtain a high-qualitychromosome-scale scaffolding shrew genome. The new reference...
Abstract Markers in five candidate genes were examined on 269 case‐parent trios ascertained through a child with an isolated, non‐syndromic oral cleft (cleft lip, CL; palate, CP; or lip and CLP). Cases their parents treatment centers Maryland. at two of the genes, transforming growth factor β3 (TGFβ3) MSX1, showed consistent evidence linkage disequilibrium due to using several statistical tests (e.g., global chi‐square for TGFβ3 was 21.1 12 df, P = 0.03; that MSX1 8.7 3 0.03). There little...
Depression is one of the most frequent psychiatric symptoms observed in people during development Alzheimer’s disease (AD). We hypothesized that genetic factors conferring risk depression might affect AD development. In this study, we screened 31 genes, which were located 19 loci for major depressive disorder (MDD) identified by two recent large genome-wide association studies (GWAS), patients at genomic and transcriptomic levels. Association analysis common variants was performed using...
Transcription factors (TFs) play important roles in plants. Among the major TFs, GATA plays a crucial role plant development, growth, and stress responses. However, there have been few studies on gene family foxtail millet (Setaria italica). The release of reference genome presents an opportunity for genome-wide characterization these genes.In this study, we identified 28 genes distributed seven chromosomes. According to classification method members Arabidopsis, SiGATA was divided into four...
Squamous promoter binding protein-like (SPL) proteins are a class of transcription factors that play essential roles in plant growth and development, signal transduction, responses to biotic abiotic stresses. The rapid development whole genome sequencing has enabled the identification characterization SPL gene families many species, but date this not been performed quinoa (Chenopodium quinoa).This study identified 23 genes quinoa, which were unevenly distributed on 18 chromosomes. Quinoa...
The GATA family of transcription factors is zinc finger DNA binding proteins involved in a variety biological processes, including plant growth and development response to biotic/abiotic stresses, thus play an essential role environmental changes. However, the gene Sorghum (SbGATA) has not been systematically analyzed reported yet. Herein, we used bioinformatics methods quantitative Real-Time Polymerase Chain Reaction (qRT-PCR) explore evolution function 33 SbGATA genes identified. These...
The tree shrew (Tupaia belangeri) is a small mammal with close relationship to primates and it has been proposed as an alternative experimental animal in biomedical research. recent release of high-quality Chinese genome enables more researchers use this species the model their studies. With aim making access extensively annotated database straightforward easy, we have created Tree Database (TreeshrewDB). This web-based platform that integrates currently available data from genome, including...
Induced expression of serum amyloid A (SAA) is a hallmark many inflammatory diseases, but whether SAA exacerbates inflammation or protects tissues against injury remains unclear. In dextran sulfate sodium (DSS)-induced colitis, SAA3 the predominant isoform inducible proteins that also include SAA1 and SAA2, mice with genetic deletion Saa3 exhibits increased production proinflammatory cytokines, decreased IL-22 along aggravated epithelium disruption, reduced colon length compared wild-type...
The Chinese tree shrew (Tupaiabelangerichinensis) is emerging as an important experimental animal in multiple fields of biomedical research. Comprehensive reference genome annotation for both mRNA and long non-coding RNA (lncRNA) crucial developing models using this species. In the current study, we collected a total 234 high-quality sequencing (RNA-seq) datasets two long-read isoform (ISO-seq) improved our previously assembled chromosome-level genome. We obtained 3 514 newly annotated...