A5020521877- Neuroendocrine Tumor Research Advances
- Peptidase Inhibition and Analysis
- Lymphoma Diagnosis and Treatment
- IgG4-Related and Inflammatory Diseases
- Multiple Myeloma Research and Treatments
- Chronic Lymphocytic Leukemia Research
- Protease and Inhibitor Mechanisms
- CNS Lymphoma Diagnosis and Treatment
- Cardiac tumors and thrombi
- Histiocytic Disorders and Treatments
- Lung Cancer Research Studies
- Sarcoma Diagnosis and Treatment
- Cardiac Structural Anomalies and Repair
- Pancreatic and Hepatic Oncology Research
- Gastrointestinal Tumor Research and Treatment
- Eosinophilic Disorders and Syndromes
- Lung Cancer Treatments and Mutations
- Medical Imaging Techniques and Applications
- Metastasis and carcinoma case studies
- Chemokine receptors and signaling
- Protein Degradation and Inhibitors
- Neuropeptides and Animal Physiology
- Adrenal and Paraganglionic Tumors
- Osteoarthritis Treatment and Mechanisms
- Advanced Nanomaterials in Catalysis
Peking Union Medical College Hospital
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Xinxiang Medical University
2023-2025
First Affiliated Hospital of Xinxiang Medical University
2025
Changchun University of Science and Technology
2025
China Shenhua Energy (China)
2023-2024
Target (United States)
2017-2024
Chengdu University
2023-2024
Key Laboratory of Nuclear Radiation and Nuclear Energy Technology
2023
Academy of Medical Sciences
1999-2020
IgG4-related disease (RD) is characterized by lymphoplasmacytic infiltration enriched in IgG4-positive plasma cells and variable degrees of fibrosis with a characteristic storiform pattern. Since an important feature IgG4-RD, we performed prospective cohort study to evaluate the performance <sup>68</sup>Ga-fibroblast activation protein inhibitor (FAPI), recently introduced PET agent targeting fibroblast protein, IgG4-RD. <b>Methods:</b> Twenty-six patients IgG4-RD were recruited. All...
Preoperative localization of insulinoma is a clinical dilemma. We aimed to investigate whether glucagon-like peptide-1 receptor (GLP-1R) PET/CT with <sup>68</sup>Ga-NOTA-MAL-cys<sup>40</sup>-exendin-4 (<sup>68</sup>Ga-NOTA-exendin-4) efficient in detecting insulinoma. <b>Methods:</b> In our prospective cohort study, patients endogenous hyperinsulinemic hypoglycemia were enrolled. CT, MRI, endoscopic ultrasound, and <sup>99m</sup>Tc-hydrazinonicotinamide-TOC SPECT/CT done according standard...
Abstract Contrast CT revealed diffuse enlargement of the pancreas with a suspicious lesion in uncinate process 57-year-old man who presented jaundice. 18 F-FDG PET/CT showed increased radioactivity enlarged nodular even higher uptake process. To differentiate autoimmune pancreatitis and pancreatic cancer, 68 Ga-FAPI was performed. It intense pancreas, but FDG-avid not shown. The patient finally diagnosed cancer tumor-induced endoscopic ultrasonography–guided biopsy.
Background In rheumatoid arthritis (RA), fibroblast-like synoviocyte cells, which are involved in inflammation of the articular cartilage and bone, overexpress fibroblast activation protein (FAP). This is a feature that could be leveraged to improve imaging assessment disease. Purpose To determine performance gallium 68 (68Ga)-labeled FAP inhibitor (FAPI) assessing joint disease activity RA compare with fluorine 18 (18F) fluorodeoxyglucose (FDG) imaging. Materials Methods Twenty participants...
Cardiovascular diseases (CVDs) pose a significant threat to human health due the high mortality and morbidity rates. Traditional drugs often have limited efficacy inherent constraints, such as low bioavailability notable side effects. As highly regarded therapeutic strategy, nanotechnology offers new perspectives means for treating CVDs. Nanozyme-based targeted specifically address biological processes in areas affected by CVDs, thereby achieving precise treatment. Compared traditional...
The aim was to assess the clinical, laboratory and radiological features of SAPHO syndrome.We recruited all patients presenting Peking Union Medical College Hospital from 2004 2015 diagnosed with syndrome. medical data, test results imaging were collected for patients.One hundred sixty-four (111 women 53 men) our cohort. mean age 40.71 years. Nine had osteoarticular symptoms without skin involvement. One forty-three 25 palmoplantar pustulosis severe acne, respectively. Psoriasis vulgaris...
Currently, 3D-bioprinting technique has emerged as a promising strategy to offer native-like tracheal substitutes for segmental trachea reconstruction. However, there been very limited breakthrough in repair using 3D-bioprinted biomimetic owing the lack of ideal bioinks, requirement precise structural biomimicking, and complexity multi-step surgical procedures by mean intramuscular pre-implantation. Herein, we propose one-step technique, namely direct end-to-end anastomosis C-shape trachea,...
Abstract Background The identification of biomarkers predicting the treatment response rheumatoid arthritis (RA) is important. [ 68 Ga]Ga-FAPI-04 showed markedly increased uptake in joints patients with RA. purpose this study to investigate whether PET/CT can be a predictor Results Nineteen diagnosed RA prospective cohort were finally enrolled. Both total synovitis (TSU) and metabolic volume (MSV) 18 F]FDG responders significantly higher than those non-responders according Clinical Disease...
Bone marrow mesenchymal stem cells (BMSCs)-based engineered cartilage usually faces the significant challenge of endochondral ossification tendency in an ectopic environment because inevitable vascular infiltration during chondrogenic differentiation and developmental stages. Additionally, current scaffold-free BMSC regeneration requires a long vitro preinduction time for before vivo transplantation, which limits its application multiple defect repair. Therefore, ideal cell-based needs to...
<sup>18</sup>F-FDG PET/CT has some limitations in the evaluation of Waldenström macroglobulinemia/lymphoplasmacytic lymphoma (WM/LPL), an indolent B-cell that primarily involves bone marrow. Because there is a high level chemokine receptor 4 expression B cells WM/LPL patients, we performed prospective cohort study to evaluate performance <sup>68</sup>Ga-pentixafor, which targets WM/LPL, and compare it with <sup>18</sup>F-FDG. <b>Methods:</b> Seventeen patients were recruited. All underwent...
A 21-year-old man had been diagnosed with immunoglobulin G4-related disease (IgG4-RD) for 5 years, and the recurred 1 month ago. F-FDG PET/CT revealed intense FDG activity in pituitary stalk, submandibular gland, pleura, pericardium, pancreas, liver, prostate, multiple lymph nodes, which were considered involvements of IgG4-RD. Ga-FAPI also showed uptake above FDG-avid lesions except node involvement. Additionally, involvement lacrimal glands was detected by Ga-FAPI. The positive findings...
POEMS (polyneuropathy, organomegaly, endocrinopathy, M protein elevation, and skin changes) syndrome is a rare paraneoplastic caused by an underlying plasma cell disorder. The patients usually present with multisystemic involvement. Thus, we performed study to investigate the role of (18)F-FDG PET/CT in characterizing syndrome.Ninety-one untreated proven or suspected were recruited undergo PET/CT. Features bone lesions, lymphadenopathy, hepatomegaly splenomegaly, marrow, serous cavity...
Three-dimensional (3D) bioprinted cartilage-mimicking substitutes for full-thickness articular cartilage defect repair have emerged as alternatives to in situ models. However, there has been very limited breakthrough regeneration based on 3D bioprinting owing the lack of ideal bioinks with printability, biocompatibility, bioactivity, and suitable physicochemical properties. In contrast animal-derived natural polymers or acellular matrices, human-derived Wharton's jelly is biocompatible...
Purpose Modifying glucagon-like peptide-1 receptor (GLP-1R)–targeted PET agent to achieve faster renal clearance and preserved high affinity GLP-1R is clinically relevant. The aim of this study assess the performance a newly developed GLP-1R–targeted agent, 68 Ga-HBED-CC-exendin-4 in localizing insulinoma, its biodistribution, as compared with previously introduced Ga-NOTA-exendin-4. Patients Methods Nineteen patients endogenous hyperinsulinemic hypoglycemia were enrolled referred for PET/CT...
To explore the patterns of osteoarticular involvement in SAPHO syndrome. Baseline clinical characteristics and imaging data 99mTc-MDP whole-body bone scintigraphy (WBBS) were collected from 157 out 164 patients diagnosed with The twelve most frequently involved sites analysed by hierarchical cluster analysis Ward minimum-variance method. Three distinctive identified: spinal type (70 patients, 44.6%), predominantly thoracic, lumbar or sacral vertebral lesions; costal (52 33.1%), lesions...
A 30-year-old woman with esophageal squamous cell carcinoma experienced joint pain and swelling in bilateral knees, wrists, hand joints during the course of neoadjuvant immunochemotherapy. She underwent 18F-FDG 68Ga-FAPI PET/CT for response assessment tumor evaluating her arthritis. detected intense uptake multiple joints, consistent polyarthritis. However, these showed only mild FDG uptake. The was complete response, polyarthritis considered as inflammatory arthritis induced by anti-PD1.
Osteochondral defects are still facing a significant challenge in clinical surgery, making post-trauma repair difficult. Tissue engineering has provided promising approach to solving these defects. However, existing scaffolds cannot replicate the complex biphasic cartilage-bone microenvironment with accuracy. We aimed develop biomimetic scaffold regionally regulated vascularization that promoted chondrogenesis and osteogenesis through bidirectional regulation of endochondral ossification....
IgG4-related disease (IgG4-RD) is a highly heterogeneous autoimmune disease. Recently, 2 subtypes of IgG4-RD, proliferative and fibrotic, were defined according to patients' clinicopathologic characteristics. The purpose this study was determine the difference in fibroinflammatory activity shown on 68Ga-FAPI-04 18F-FDG PET/CT fibrotic IgG4-RD subtypes. Methods: Thirty-seven newly diagnosed patients (29 subtype 8 subtype) who had undergone enrolled. SUVmax target-to-background ratio (TBR)...