A5101689661- Ion channel regulation and function
- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Ion Transport and Channel Regulation
- Cancer Risks and Factors
- HER2/EGFR in Cancer Research
- Adipokines, Inflammation, and Metabolic Diseases
- Plant-Microbe Interactions and Immunity
- Cancer, Lipids, and Metabolism
- Cardiac electrophysiology and arrhythmias
- Pancreatic and Hepatic Oncology Research
- Pediatric Hepatobiliary Diseases and Treatments
- Plant Virus Research Studies
- Erythrocyte Function and Pathophysiology
- Studies on Chitinases and Chitosanases
- Orthopedic Surgery and Rehabilitation
- Monoclonal and Polyclonal Antibodies Research
- Shoulder Injury and Treatment
- Cancer Mechanisms and Therapy
- Plant tissue culture and regeneration
- Microtubule and mitosis dynamics
- Intestinal and Peritoneal Adhesions
- Breast Cancer Treatment Studies
- Sarcoma Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
Yunnan Agricultural University
2023-2024
Nanchang University
2010-2024
First Affiliated Hospital of Nanchang University
2024
West China Medical Center of Sichuan University
2021-2023
Zhejiang University
2005-2023
Sir Run Run Shaw Hospital
2005-2023
Tongde Hospital of Zhejiang Province
2023
Guangdong Pharmaceutical University
2008-2021
Guangxi University of Chinese Medicine
2012-2016
Jinan University
2012
Although thaumatin-like proteins (TLPs) are involved in resistance to a variety of fungal diseases, whether the TLP5 and TLP6 genes tomato plants (Solanum lycopersicum) confer pathogenesis soil-borne diseases has not been demonstrated. In this study, five (fungal pathogens: Fusarium solani, oxysporum, Verticillium dahliae; bacterial Clavibacter michiganense subsp. Ralstonia solanacearum) were used infect susceptible "No. 5" disease-resistant "S-55" cultivars. We found that SlTLP5 SlTLP6...
In the post-genomic era, virus-induced gene silencing (VIGS) has played an important role in research on reverse genetics plants. Commonly used Agrobacterium -mediated VIGS inoculation methods include stem scratching, leaf infiltration, use of agrodrench, and air-brush spraying. this study, we developed a root wounding–immersion method which 1/3 plant (length) was cut immersed tobacco rattle virus (TRV)1:TRV2 mixed solution for 30 min. We optimized procedure Nicotiana benthamiana...
ClC-3, a gene encoding candidate protein for volume-activated chloride (C(-)) channels, may be involved in tumor development. Herein we report study using an antisense "knock-down" strategy to investigate the mechanism by which ClC-3 affects cell proliferation nasopharyngeal carcinoma CNE-2Z cells. With immunoblots and MTT assays demonstrated that expression of was cycle dependent similar concentration-dependent manner, oligonucleotide specific inhibited proliferation. The level correlated...
Abstract Tamoxifen is a triphenylethylene non‐steroidal antiestrogen anticancer agent. It also shows inhibitory effects on metastasis of estrogen receptor (EsR)‐independent tumors, but the underlying mechanism unclear. was demonstrated in this study that, EsR‐negative and highly metastatic human hepatocellular carcinoma MHCC97H cells, tamoxifen‐inhibited cell migration, volume‐activated Cl − currents (I Cl,vol ) regulatory volume decrease (RVD) concentration‐dependent manner with similar IC...
// Bin Xu 1,4,* , Xiaobao Jin 1,2,* Ling Min 5,* Qin Li 1,2 Lulu Deng 1,6 Hui Wu 2 Guixian Lin Lixin Chen 3 Haifeng Zhang Chunmei Liwei Wang Jiayong Zhu Weizhang Fujiang Chu Juan Shen 1,4 Hongzhi and Jianwen Mao 1 Guangdong Key Laboratory for Bioactive Drugs Research, Pharmaceutical University, Guangzhou, China School of Basic Medicine, Department Pharmacology Physiology, Medical College, Jinan 4 Biosciences Biopharmaceutics, 5 Cancer Center Guangzhou 6 Pharmacology, * These authors...
Abstract Chloride channel‐3 (ClC‐3), a member of the ClC family voltage‐gated Cl − channels, is involved in resistance tumor cells to chemotherapeutic drugs. Here, we report new mechanism for ClC‐3 mediating multidrug (MDR). was highly expressed P‐glycoprotein (P‐gp)‐dependent human lung adenocarcinoma cell line (A549)/paclitaxel (PTX) and breast carcinoma (MCF‐7)/doxorubicin (DOX) resistant cells. Changes expression resulted development drug formerly drug‐sensitive A549 or MCF‐7 cells,...
P-glycoprotein (P-gp) is encoded by the multidrug resistance (MDR1) gene and well studied as a multi-drug transporter. Peritoneal adhesion formation following abdominal surgery remains an important clinical problem. Here, we found that P-gp was highly expressed in human fibroblasts promoted peritoneal rodent model. Knockdown of expression intraperitoneal injection MDR1-targeted siRNA significantly reduced both development rate grades. Additionally, operative injury up-regulated through...
Abstract There is strong evidence to suggest that obesity-related proteins play a key role in pathways are related breast cancer. In this study, we aimed establish robust protein score (ORPS) could be used assess cancer risk. Based on from high-quality systematic reviews and population studies, selected nine such stable vitro, measured their circulating concentrations by ELISA case–control study conducted Chengdu, Sichuan, China, with 279 cases 260 healthy controls. Two scores were...
Stretch-activated chloride currents (I(Cl,SA) ) have been considered to be a component of volume-activated (I(Cl,vol) for some time. This is due similarity in biophysical and pharmacological properties that involve membrane curvature-induced mechanism rearrangement the cytoskeleton induced by cell swelling or stretch. In present study, we demonstrated current density, along with time taken from activation peak, were significantly different between two currents, highly metastatic human...
Verticillium wilt, caused by dahliae, is a soil-borne disease affecting eggplant. Wild eggplant, recognized as an excellent disease-resistant resource against verticillium plays pivotal role in grafting and breeding for resistance. However, the underlying resistance mechanisms of wild eggplant remain poorly understood. This study compared two varieties, LC-2 (high resistance) LC-7 (sensitive) at phenotypic, transcriptomic, metabolomic levels to determine molecular basis their wilt. These...
Cell migration is crucial for tumor metastasis. Membrane ion channels may play a major role in cell because the cells must undergo changes shape and volume during migration. In present study, we used transwell assay, an vitro model migration, patch-clamp technique to investigate of volume-activated Cl- current (Icl,vol) regulation nasopharyngeal carcinoma CNE-2Z cells. 5-Nitro-2- (3-phenylpropylamino) benzoic acid (NPPB) inhibited Icl,vol with almost identical dose-dependent pattern (IC50...