A5100326636- Cervical and Thoracic Myelopathy
- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Lung Cancer Treatments and Mutations
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer-related Molecular Pathways
- Cancer Genomics and Diagnostics
- Cancer Research and Treatments
- Antioxidant Activity and Oxidative Stress
- Colorectal Cancer Treatments and Studies
- Cancer-related molecular mechanisms research
- Gastric Cancer Management and Outcomes
- Nail Diseases and Treatments
- Wound Healing and Treatments
- Intraperitoneal and Appendiceal Malignancies
- NF-κB Signaling Pathways
- Intergenerational Family Dynamics and Caregiving
- Metastasis and carcinoma case studies
- Ear Surgery and Otitis Media
- Advanced Breast Cancer Therapies
- Breast Cancer Treatment Studies
- Spinal Hematomas and Complications
- Telomeres, Telomerase, and Senescence
- Digestive system and related health
- Fungal Infections and Studies
Jiangsu Cancer Hospital
2024
Nanjing Medical University
2024
First People's Hospital of Jingzhou
2024
Zhengzhou Fruit Research Institute
2023
Ministry of Agriculture and Rural Affairs
2023
Chinese Academy of Agricultural Sciences
2023
Pfizer (China)
2022
Ministry of Education of the People's Republic of China
2020
Eye & ENT Hospital of Fudan University
2020
Shanghai Medical Information Center
2020
Intestinal epithelial cell (IEC) apoptosis contributes to the development of ulcerative colitis (UC), an inflammatory bowel disease (IBD) that affects colon and rectum. Therapies target cytokine TNF have been found inhibit IEC in patients with IBD, although mechanism remains unclear. We therefore investigated role p53-upregulated modulator (PUMA), a p53 proapoptotic BH3-only protein, apoptosis, using patient samples mouse models UC. In UC samples, PUMA expression was elevated tissues...
Nonsteroidal anti-inflammatory drugs (NSAIDs) such as sulindac effectively prevent colon cancer in humans and rodent models. However, their cellular targets underlying mechanisms have remained elusive. We found that dietary induced apoptosis to remove the intestinal stem cells with nuclear or phosphorylated β-catenin APC Min/+ mice. NSAIDs also human colonic polyps removed aberrant Wnt signaling. Furthermore, deficiency SMAC, a mitochondrial apoptogenic protein, attenuated tumor-suppressive...
Abstract Background Although EGFR-TKI resistance mechanisms in non-small cell lung cancer (NSCLC) have been extensively studied, certain patient subgroups remain with unclear mechanisms. This retrospective study analysed mutation data of NSCLC patients EGFR -sensitive mutations and high programmed death-ligand 1 (PD-L1) expression or TMB to identify primary Methods Hybrid capture-based next-generation sequencing (NGS) was used analyse 639 genes tumor tissues blood samples from 339 patients....
Ossification of the posterior longitudinal ligament is a common cause cervical myelopathy, and controversy remains regarding surgical options. Between January 2004 December 2007, total 164 patients with ossification in spine who underwent treatment at authors’ institution were included this study. The choice option was based on pathological extent alignment. Short-segment pathology treated via anterior approach long-segment approach. When selected, laminoplasty performed for lordosis...
Aging is associated with progressive telomere shortening, resulting in the formation of dysfunctional telomeres that compromise tissue proliferation. However, can limit tumorigenesis by activating p53-dependent cellular senescence and apoptosis. While activation both apoptosis required for repress tumor formation, it not clear which pathway major suppressive vivo. In this study, we generated Eμ-myc; Pot1b∆/∆ mouse to directly compare under conditions either or activated devoid shelterin...
Cervical total disk arthroplasty has proven to be an effective and safe alternative for anterior cervical diskectomy fusion (ACDF) the treatment of degenerative disease. However, whether when is indicated preoperative spine kyphosis unclear. In authors’ clinical experiences, can generally divided into reducible irreducible forms according results dynamic flexion-extension lateral radiographs. Reducible mostly related local prolapse, symptoms, musculature weakness, but always associated with...
P-glycoprotein (P-gp) is encoded by the multidrug resistance (MDR1) gene and well studied as a multi-drug transporter. Peritoneal adhesion formation following abdominal surgery remains an important clinical problem. Here, we found that P-gp was highly expressed in human fibroblasts promoted peritoneal rodent model. Knockdown of expression intraperitoneal injection MDR1-targeted siRNA significantly reduced both development rate grades. Additionally, operative injury up-regulated through...
Between January 1996 and December 2005, a total of 1241 patients underwent anterior cervical decompression fusion for degenerative diseases in the authors’ institution. Sixty-three (5.1%) revision diskectomy adjacent segment disease between October 2003 August 2010. This series included 35 men 28 women with mean±SD age 52.6±6.7 years. A 81 segments surgery, most were distributed at C3–C4 C6–C7. Patients evaluated using visual analog scale Japanese Orthopaedic Association score pre-...
Abstract: Osimertinib, an irreversible EGFR/HER2 inhibitor, has been found to be effective in the cancer cell with EGFR gene mutations preclinical lung models. However, effect of osimertinib colorectal (CRC) cells is unclear. In present study, we investigated how suppresses CRC growth and potentiates effects other chemotherapeutic drugs. We that p73-mediated osimertinib-induced p53 upregulated modulator apoptosis (PUMA) expression irrespective status following PI3K/AKT pathway inhibition...
Abstract Background Onychomycosis, a disease was with high global prevalence, has been the focal point of this study. The research aims to compare diagnostic efficacy among various methods, including potassium hydroxide (KOH), Dimethyl sulfoxide (DMSO), specific colour staining (Chlorazol, lactophenol cotton blue and Chicago sky stain), fluorescent (calcofluor white stain, acridine orange dye), culture on dermatophyte test medium (DTM), conventional PCR, dermoscopy, histopathological...
Epidemiological and in vitro studies suggest that antioxidants such as quercetin vitamin E (VE) can prevent lung tumor caused by smoking; however, there is limited evidence from animal studies.In the present study, Swiss mouse was used to examine potential of VE for prevention induced smoking.Our results incidence multiplicity were 43.5% 1.00 +/- 0.29 smoking group; Quercetin has effects on this vivo model, measured assays free radical scavenging, reduction smoke-induced DNA damage...
<b><i>Objective:</i></b> The objective of this study is to describe the clinical features, managements and outcomes a rare coexistence congenital ossicular anomaly localized cholesteatoma. A literature review on these cases each disorder also presented. <b><i>Methods:</i></b> retrospective chart was performed patients diagnosed with concurrent cholesteatoma from 2008 2017. Clinical data were collected....
Objective To compare the incidence of secondary surgical procedures after cervical disc arthroplasty vs anterior discectomy with fusion in patients treated for symptomatic single level spondylosis. Methods An online search Pubmed, Medline, Ovid, Embase, Cochrane Library, CBM database, Wanfang data and VIP database were searched prospective randomized controlled trial versus procedures. Data collected extracted by two reviewers independently. Risk bias was assessed using criteria...
Abstract In budding yeast, Sir2 is a NAD+-dependent histone deacetylase that plays role in chromatin silencing, longevity and genomic stability. mammals, sirtuins exist as family of 7 members (SIRT1-7) deacetylate histones many nonhistone proteins. Currently, all have been knocked out by gene targeting, the mutant mice suffer various abnormalities cell growth, apoptosis, neurological behavior, adaptation to calorie restriction, organ metabolism function, and/or premature aging, highlighting...
Objective To investigate the correlation among sleep quality, living quality and mental state gerontal patients in hospital. Methods Pittsburgh Sleep Quality Index (PSQI), Short Form Health Survey (SF-36), Geriatric Depression Scale (GDS) Self-rating Anxiety (SAS) were adopted to states 78 from April November 2011, who older than 75 years hospital. Measurement data of normal distribution was expressed by±s, comparison between two groups evaluated by independent-samplesttest,...
<p>Table A1 PBSO and BC risk in BRCA1/2 mutation carriers</p>
Objective To investigate the efficacy and safety of preoperative regional intra-arterial chemoembolization combined with systemic vein chemotherapy in treatment locally advanced gastric cancer. Methods The clinical data 78 cancer patients treated by radical D2 gastretomy from January 2010 to December 2012 were retrospectively analyzed. Patients devided into group receiving (n=36), those (n=42) 3 4 weeks before surgery. Systemic mFOLFOX6 was started after 5 surgery two...