A5101492598- Liquid Crystal Research Advancements
- Fibroblast Growth Factor Research
- Hydrogels: synthesis, properties, applications
- Connective tissue disorders research
- Electrospun Nanofibers in Biomedical Applications
- Intraocular Surgery and Lenses
- Corneal surgery and disorders
- Ophthalmology and Visual Impairment Studies
- biodegradable polymer synthesis and properties
- Bone Tissue Engineering Materials
- Osteoarthritis Treatment and Mechanisms
- Photonic and Optical Devices
- Photonic Crystals and Applications
- Graphene and Nanomaterials Applications
- Electrochemical sensors and biosensors
- Liver Disease Diagnosis and Treatment
- Advanced Materials and Mechanics
- Surfactants and Colloidal Systems
- Microbial Fuel Cells and Bioremediation
- Pickering emulsions and particle stabilization
- Erythrocyte Function and Pathophysiology
- Tissue Engineering and Regenerative Medicine
- Polymer Surface Interaction Studies
- Semiconductor Lasers and Optical Devices
- Colorectal Cancer Treatments and Studies
Hong Kong Science and Technology Parks Corporation
2023-2024
City University of Hong Kong
2020-2024
Laboratoire Interdisciplinaire de Physique
2024
Tsinghua University
2024
Guangxi Medical University
2022-2024
Second Affiliated Hospital of Zhejiang University
2021-2024
Chinese University of Hong Kong
2024
Affiliated Hospital of Southwest Medical University
2024
First Affiliated Hospital of GuangXi Medical University
2022-2023
Army Medical University
2007-2023
Keywords: bone morphogenetic protein-2, regeneration, graphene oxides, stem cell recruitment, substance P
Nanosized celluloses are attractive building blocks to generate hierarchically advanced materials and have been gradually explored in emulsion applications. Here we report a high internal phase (HIPE) prepared by using supramolecular cellulose nanocrystals (CNCs) as Pickering stabilisers via one-step emulsification, interconnected macroporous hybrid hydrogels were produced utilizing this HIPE template. A quadruple hydrogen bonding moiety 2-ureido-4[1H]-pyrimidone (UPy) was firstly grafted...
The bidirectional relationship between osteochondral defects (OCD) and osteoarthritis (OA), with each condition exacerbating the other, makes OCD regeneration in presence of OA challenging. Type II collagen (Col2) is important management OA, but its potential applications cartilage tissue engineering are significantly limited. This study investigated capacity Col2 scaffolds critical-sized OCDs under surgically induced conditions explored underlying mechanisms that promoted regeneration....
Abstract With high biocompatibility and degradability, polysaccharide‐based hydrogels are favorable healthcare materials. However, in many biomedical applications, these materials inconvenient to handle with fixed morphology, unable closely match the wounds, easy detach due insufficient adhesion. Inspired by superior wet adhesive properties of marine mussels, researchers have used mussel‐inspired chemistry create mussel‐mimetic injectable that simple operate, controllable shape, highly...
Sponge-like porous Ni(OH)(2)-NiF(2) composite (PNC) film was successfully synthesized by the anodization of nickel in a NH(4)F and H(3)PO(4) containing electrolyte. Thanks to good conductivity highly architecture, PNC exhibited not only high specific capacitance, but also superior rate capability cyclability (2090 F g(-1) at 10 mV s(-1), capacitance >1200 100 A after 2000 cycles). Anodization is proven be fast facile can easily scaled up. The method described here promising for fabrication...
FGFR3 (fibroblast growth factor receptor 3) is a negative regulator of endochondral ossification. Gain-of-function mutations in are responsible for achondroplasia, the most common genetic form dwarfism humans. Autophagy, an evolutionarily conserved catabolic process, maintains chondrocyte viability plate under stress conditions, such as hypoxia and nutritional deficiencies. However, role autophagy its underlying molecular mechanisms achondroplasia remain elusive. In this study, we found...
Hydrogels with self-healing features that can spontaneously repair themselves upon mechanical damage are increasingly attractive for biomedical applications. Many attempts have been made to develop unique hydrogels possessing this property, as well stimuli-responsiveness and biocompatibility; however, the hydrogel fabrication strategies often involve specific design of functional monomers able optimally provide reversible physical or chemical interactions. Here, we report weak hydrogen...
Abstract Self‐healable hydrogels are promising soft materials with great potential in biomedical applications due to their autonomous self‐repairing capability. Although many attempts made develop new good self‐healing performance, integrate this characteristic along other responsive multifunctions into one hydrogel still remains difficult. Here, a self‐healable hybrid supramolecular (HSH) tunable bioadhesive and stimuli‐responsive properties is reported. The strategy imparting graphene...
Gut microbiome plays an indispensable role in the occurrence and progression various diseases. The incidence of pancreatic cancer (PC) liver metastasis (PCLM) are high, most them found advanced stage. Therefore, it is particularly necessary to search for predictive biomarkers, which helpful early detection treatment, thus improve survival rate quality life PC patients.We retrospectively analyzed 44 patients (P group, n = 44) 50 healthy people (N 50) from March 21, 2021 August 2, 2022. Among...
Abstract Catechins from green tea are one of the most effective natural compounds for cancer chemoprevention and have attracted extensive research. Cancer cell‐selective apoptosis‐inducing properties catechins depend on efficient intracellular delivery. However, low bioavailability limits application catechins. Herein, a nano‐scaled micellar composite composed catechin‐functionalized cationic lipopolymer serum albumin is constructed. Cationic liposomes tend to accumulate in pulmonary...
Conductive and antimicrobial macroporous hydrogels have shown promising applications in promoting soft tissue regeneration.
Abstract Due to the safety issue and poor underwater adhesion of current commercially available bioadhesives, they are hard apply in vivo physiological environments more diverse medical use conditions. In this study, a novel facile bioadhesive for applications designed based on coacervation electrostatic interactions hydrophobic interactions, with introduction catechin as provider catechol moieties surrounding tissues. The orange‐colored bio‐adhesive, named PcC, is generated within seconds...
Gain-of-function mutations in fibroblast growth factor receptor-3 (FGFR3) lead to several types of human skeletal dysplasia syndromes including achondroplasia, hypochondroplasia and thanatophoric (TD). Currently, there are no effective treatments for these diseases. In this study, we screened, using FGFR3 as a bait, random 12-peptide phage library obtained 23 positive clones that share identical amino acid sequences (VSPPLTLGQLLS), named peptide P3. This had high binding specificity the...
Abstract We have shown that prothrombin kringle‐2 (pKr‐2), a domain of human distinct from thrombin could activate cultured rat brain microglia in vitro. However, little is known whether pKr‐2‐induced microglial activation cause neurotoxicity on dopaminergic (DA) neurons vivo. To address this question, pKr‐2 was injected into the substantia nigra (SN). Tyrosine hydroxylase (TH) immunohistochemistry experiments demonstrate significant loss DA seven days after injection pKr‐2. In parallel,...