A5101833758- Bone Tissue Engineering Materials
- Electrospun Nanofibers in Biomedical Applications
- 3D Printing in Biomedical Research
- Hydrogels: synthesis, properties, applications
- Osteoarthritis Treatment and Mechanisms
- Tissue Engineering and Regenerative Medicine
- Silk-based biomaterials and applications
- Surgical Sutures and Adhesives
- Graphene and Nanomaterials Applications
- Additive Manufacturing and 3D Printing Technologies
- Periodontal Regeneration and Treatments
- Wound Healing and Treatments
- Polymer Surface Interaction Studies
- Dental Implant Techniques and Outcomes
- Hemostasis and retained surgical items
- Supramolecular Self-Assembly in Materials
- Facial Trauma and Fracture Management
- Antimicrobial Peptides and Activities
- Innovative Microfluidic and Catalytic Techniques Innovation
- Advanced Sensor and Energy Harvesting Materials
- Hippo pathway signaling and YAP/TAZ
- Endometriosis Research and Treatment
- Medical Imaging and Analysis
- Nanoplatforms for cancer theranostics
- Hernia repair and management
South China University of Technology
2016-2025
Dalian Maritime University
2023-2025
National Research Center for Rehabilitation Technical Aids
2016-2024
Kangda College of Nanjing Medical University
2024
Nanjing Medical University
2024
The First People’s Hospital of Lianyungang
2024
Hebei University of Technology
2022-2023
China National Offshore Oil Corporation (China)
2022
Hospital of Hebei Province
2022
Zhongshan Hospital
2021
Three-dimensional (3D) printing holds great potential for preparing sophisticated scaffolds tissue engineering. As a result of the shear thinning properties an alginate solution, it is often used as 3D ink. However, difficult to prepare with complexity structure and high fidelity, because solution has low viscosity hydrogels prepared Ca2+ crosslinking are mechanically weak. In this work, chitosan powders were dispersed swelled in which could effectively improve by 1.5⁻4 times. With increase...
Hydrogel scaffolds are attractive for tissue defect repair and reorganization because of their human tissue-like characteristics. However, most hydrogels offer limited cell growth formation ability due to submicron- or nano-sized gel networks, which restrict the supply oxygen, nutrients inhibit proliferation differentiation encapsulated cells. In recent years, 3D printed have shown great potential overcome this problem by introducing macro-pores within scaffolds. study, we fabricated a...
Bacterial infection, excessive inflammation and damaging blood vessels network are the major factors to delay healing of diabetic ulcer. At present, most wound repair materials passive can't response microenvironment, resulting in a low utilization bioactive substances hence poor therapeutic effect. Therefore, it's essential design an intelligent dressing responsive microenvironment achieve release drugs on-demand on basis multifunctionality. In this work, metformin-laden CuPDA NPs composite...
Abstract In this paper, a novel bioinspired stem cell‐laden microgel and related in vivo cartilage repair strategy are proposed. particular, herein the preparation of new microgels, which can be injected into chondral defect site minimally invasive way, more importantly, capable situ self‐assembly 3D macroporous scaffold without external stimuli, is presented. Specifically, thiolated gelatin (Gel‐SH) vinyl sulfonated hyaluronic acid (HA‐VS) first synthesized, then gelatin/hyaluronic hybrid...
Titanium (Ti) alloy implants can repair bone defects at load-bearing sites. However, they mechanically mismatch with the natural and lack customized adaption irregularly major-sized defects, resulting in failure of implant fixation. Mineralized collagen (MC), a building block bone, induce angiogenesis osteogenesis, 3D printing technology be employed to prepare scaffolds an overall shape defect. Hence, we induced formation MC, made hydroxyapatite (HAp) nanocrystals fibers, 3D-printed porous...
Natural matrices are engineered with black phosphorus nanosheets to generate therapeutic nanocomposite hydrogels promising multi-functions, providing a facile and efficient strategy for bone tissue engineering.
The increasing insight into the molecular and cellular processes within angiogenic cascade assists in enhancing survival integration of engineered bone constructs. Copper-doped bioactive glass (Cu-BG) is now a potential structural component novel scaffolds implants used orthopedic dental repairs. However, it difficult for BG, especially micro-nano particles, to be printed still retain its biological activity ability biodegrade. Additionally, mechanisms copper-stimulating autocrine paracrine...
Extrusion bioprinting has been widely used to fabricate complicated and heterogeneous constructs for tissue engineering regenerative medicine. Despite the remarkable progress acquired so far, exploration of qualified bioinks is still challenging, mainly due conflicting requirements on printability/shape-fidelity cell viability. Herein, a new strategy proposed formulate dynamic cross-linked microgel assembly (DC-MA) bioink, which can achieve both high viability by strengthening intermicrogel...
Biomimetic multi-furcated vessels (MFVs) and heterogeneous porous scaffolds containing (HPS-MFVs) can be fabricated by combining stimuli-responsive gelatin/chitosan hydrogels 3D printing technology.
The treatment for diabetic ulcers still remains a big clinic challenge owing to the adverse repair microenvironment. Bioactive glasses (BGs) play an important role in late stages of healing due their ability promote vascularization and collagen fiber deposition, but fail improve infection oxidative stress early stage.Therefore, it is critical develop material involved regulating whole phases. In this work, BGs-based nanozymes (MnO2 @PDA-BGs) with antioxidation, antibacterial pro-healing...
Bacterial infection has been considered one of the primary reasons for low survival rate lung cancer patients. Herein, we demonstrated that a kind mesoporous silica nanoparticles loaded with anticancer drug doxorubicin (DOX) and antimicrobial peptide HHC36 (AMP) (MSN@DOX-AMP) can kill both commensal bacteria tumor cells under GSH-triggering, modulating immunosuppressive microenvironment, significantly treating bacterial infection, eliminating in situ tumors model. Meanwhile, MSN@DOX-AMP...
In the fabrication of 3-D complex tissues for implantation, layer-by-layer (LBL) electrospun nanofibrous scaffolds have recently received intensive interest. However, poor cell adhesion and expansion between layers in an LBL stack remain important issues. this study, we report a mussel-inspired, biomimetic approach to functionalize surface PCL/gelatin membranes coated with poly (dopamine) (PDA). Our study demonstrates that PDA coating on nanofibers leads significant change their properties...
In recent years medical devices manufacturers have been looking for antimicrobial coatings which are biocompatible and non-toxic a wide range of devices.
A medical adhesive called TASK based on polyphenol-gel systems was developed and showed wet-adhesive, stretchable, self-healing restorable properties.
Abstract Owing to the lack of blood vessels, nerves, and lymph, articular cartilage defect is difficult self‐repair. Although several tissue engineering products have been authorized for clinical use, there are still some problems such as large surgical wounds, weak adhesion with host tissue, limited source autologous chondrocytes. In this paper, a novel dynamic nanocomposite microgel assembly excellent microporosity, injectability, tissue‐adhesion, sustained kartogenin (KGN) release...
In this study, nanocellulose aerogels with a tunable Poisson’s ratio were fabricated. Tissue engineering scaffolds may be better able to simulate the mechanical behavior of natural tissues. A mixture cellulose nanofibers (CNFs) and polyethylene glycol diacrylate (PEGDA) was used as raw material prepare CNF/PEGDA multiscale pore structure through combination stereolithography (SLA) freeze-drying. The fabricated regular macropore network random homogeneous distribution micropores. could...