Chao Ran

ORCID: 0000-0003-1799-549X
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About
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Research Areas
  • Aquaculture disease management and microbiota
  • Aquaculture Nutrition and Growth
  • Gut microbiota and health
  • Aquatic life and conservation
  • Bacteriophages and microbial interactions
  • Invertebrate Immune Response Mechanisms
  • Vibrio bacteria research studies
  • Animal Nutrition and Physiology
  • Bacterial biofilms and quorum sensing
  • Probiotics and Fermented Foods
  • Antimicrobial Peptides and Activities
  • Free Radicals and Antioxidants
  • Adipose Tissue and Metabolism
  • Enzyme Production and Characterization
  • Pharmaceutical and Antibiotic Environmental Impacts
  • Liver Disease Diagnosis and Treatment
  • Bacterial Genetics and Biotechnology
  • Myxozoan Parasites in Aquatic Species
  • Infections and bacterial resistance
  • Peroxisome Proliferator-Activated Receptors
  • Plant-Microbe Interactions and Immunity
  • Immune Cell Function and Interaction
  • Immune Response and Inflammation
  • Animal Genetics and Reproduction
  • Diet, Metabolism, and Disease

Feed Research Institute
2016-2025

Chinese Academy of Agricultural Sciences
2016-2025

Ministry of Agriculture and Rural Affairs
2019-2024

Jiangmen Wuyi Traditional Chinese Medicine Hospital
2023

Jilin Agricultural University
2018-2023

Army Medical University
2022-2023

Chongqing Medical University
2020-2023

Second Affiliated Hospital of Chongqing Medical University
2022-2023

Dalian Medical University
2022-2023

South China University of Technology
2023

Abstract The gastrointestinal (GI) microbiota of vertebrates plays critical roles in nutrition, development, immunity and resistance against invasive pathogens. In the past decade, research GI mammals has drastically increased our knowledge on their relationship with health disease. However, understanding fish intestinal is limited. This review provides an overview gut microbiota, including microbial composition, formation, factors that affect microbes characteristics compared human mice....

10.1111/raq.12191 article EN cc-by-nc-nd Reviews in Aquaculture 2017-02-02

The capability of carbohydrate utilization in fish is limited compared to mammals. It has scientific and practical significance improve the ability use carbohydrates. efficiency dietary varies among with different feeding habits, which are associated differential intestinal microbiota. In this study, we found that zebrafish fed omnivorous diet (OD) herbivorous (HD) showed better glucose homeostasis carnivorous (CD) counterpart was attributable commensal bacterium Cetobacterium somerae, an...

10.1080/19490976.2021.1900996 article EN cc-by Gut Microbes 2021-01-01

The gut microbiota plays an important role in host health and disease. Our understanding of the fish lags far behind our knowledge that humans other mammals. Nevertheless, research has highlighted importance health, performance, various physiological functions fish. been studied species, including model animals, economic fish, wild species. composition depends on selection, diet, environmental factors. intestinal affects nutritional metabolism, immunity, disease resistance host, while...

10.1016/j.eng.2022.12.011 article EN cc-by-nc-nd Engineering 2023-03-16

Abstract Background Aquaculture plays an important role in global protein supplies and food security. The ban on antibiotics as feed additive proposes urgent need to develop alternatives. Gut microbiota roles the metabolism immunity of fish has potential give rise novel solutions for challenges confronted by culture. However, our understanding gut microbiome is still lacking. Results We identified 575,856 non-redundant genes metagenomic sequencing intestinal content samples grass carp....

10.1186/s40168-023-01715-7 article EN cc-by Microbiome 2024-01-03

Bacillus strains isolated from soil or channel catfish intestine were screened for their antagonism against Edwardsiella ictaluri and Aeromonas hydrophila, the causative agents of enteric septicemia (ESC) motile aeromonad septicaemia (MAS), respectively. Twenty one selected antagonistic activity other aquatic pathogens was also tested. Each top 21 expressed multiple bacterial including tarda, Streptococcus iniae, Yersinia ruckeri, Flavobacterium columnare, and/or oomycete Saprolegnia ferax....

10.1371/journal.pone.0045793 article EN cc-by PLoS ONE 2012-09-21

Summary Aeromonas species are ubiquitous inhabitants of freshwater environments, and responsible for fish motile aeromonad septicemia (MAS). A. hydrophila is implicated as the primary etiologic agent MAS. Here, we analysed MAS epidemiological data cyprinid in southern China, found that veronii infections dominated. Consistent with this observation, isolates were generally more virulent than when infecting germ‐free zebrafish larvae via continuous immersion challenge. Through vivo screening...

10.1111/1462-2920.14390 article EN Environmental Microbiology 2018-08-23

Abstract Natural polysaccharides have received much attention for their ability to ameliorate hepatic steatosis induced by high-fat diet. However, the potential risks of use been less investigated. Here, we show that exopolysaccharides (EPS) from Lactobacillus rhamnosus GG (LGG) and L. casei BL23 reduce in zebrafish fed a diet, while EPS, but not LGG induce liver inflammation injury. This is due fact EPS induces gut microbial dysbiosis, promotes homeostasis. We find can directly activate...

10.1038/s42003-019-0526-z article EN cc-by Communications Biology 2019-07-25

Probiotics are widely used in aquafeeds and exhibited beneficial effects on fish by improving host health resisting pathogens. However, probiotics applied to aquaculture mainly from terrestrial sources instead of the animal. The purpose work was evaluate stabilized fermentation product commensal Cetobacterium somerae XMX-1 gut, liver antiviral immunity zebrafish. A total 240 zebrafish were assigned control (fed a basal diet) group diet with 10 g XMX-1/kg diet). After four weeks feeding,...

10.1016/j.fsi.2021.11.017 article EN cc-by-nc-nd Fish & Shellfish Immunology 2021-11-13

The gill is an important organ in fish that involved various physiological functions, including respiration, filter-feeding, ammonia nitrogen excretion, and osmoregulation. functions of gills are closely related to their structure, external feeding conditions, environmental factors. Herein, we first briefly summarize the basic structure teleosts, then explain function barrier (as a microbial barrier, chemical physical immune barrier) detail. Finally, introduce regulation health by ubiquitous...

10.1016/j.watbs.2023.100139 article EN cc-by Water Biology and Security 2023-01-24

Fish gut barrier damage under intensive culture model is a significant concern for aquaculture industry. This study aimed to investigate the effects of bile acids (BAs) on barriers in Micropterus salmoides. A germ-free (GF) zebrafish was employed elucidate direct stimulation BAs and indirect regulations mediated by microbiota functions. Four diets were formulated with supplemented at 0, 150, 300 450 mg/kg, these 4 defined as control, BA150, BA300 BA450, respectively. After 5 weeks feeding...

10.1016/j.aninu.2023.03.008 article EN cc-by-nc-nd Animal nutrition 2023-04-20

Abstract Lactobacillus rhamnosus GG (LGG), the well‐characterized human‐derived probiotic strain, possesses excellent properties in maintenance of intestinal homeostasis, immunoregulation and defense against gastrointestinal pathogens mammals. Here, we demonstrate that SpaC pilin LGG causes epithelium injury by inducing cell pyroptosis gut microbial dysbiosis zebrafish. Dietary activates Caspase‐3−GSDMEa pathways epithelium, promotes increases lipopolysaccharide (LPS)‐producing microbes The...

10.1002/imt2.181 article EN cc-by iMeta 2024-03-25
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