A5100333221- Nutrition, Genetics, and Disease
- Genetic Associations and Epidemiology
- Genomics and Rare Diseases
- Genetic Mapping and Diversity in Plants and Animals
- Genetic and phenotypic traits in livestock
- Connective tissue disorders research
- Fibroblast Growth Factor Research
- Genomics and Phylogenetic Studies
- Skin Protection and Aging
- Genetic diversity and population structure
- Lipid metabolism and biosynthesis
- Cancer Genomics and Diagnostics
- Fatty Acid Research and Health
- Estrogen and related hormone effects
- melanin and skin pigmentation
- Genetics and Plant Breeding
- Animal Genetics and Reproduction
- Mechanisms of cancer metastasis
- Genomic variations and chromosomal abnormalities
- Consumer Attitudes and Food Labeling
- TGF-β signaling in diseases
- T-cell and B-cell Immunology
- Muscle Physiology and Disorders
- Statistical Methods in Clinical Trials
- Advanced Causal Inference Techniques
Fudan University
2010-2025
National Animal Husbandry Service
2023-2024
Ministry of Agriculture and Rural Affairs
2023
National Engineering Research Center for Information Technology in Agriculture
2023
Indiana University Bloomington
2009-2021
University of Alberta
2014-2019
Institute for Research in Immunology and Cancer
2019
Wenzhou University
2018
Fudan University Shanghai Cancer Center
2016
Army Medical University
2012-2014
Genome-wide association studies (GWAS) aim at discovering the between genetic variations, particularly single-nucleotide polymorphism (SNP), and common diseases, which is well recognized to be one of most important active areas in biomedical research. Also renowned privacy implication such studies, has been brought into limelight by recent attack proposed Homer et al. Homer's demonstrates that it possible identify a GWAS participant from allele frequencies large number SNPs. Such threat,...
The Global Alliance for Genomics and Health (GA4GH) created the Beacon Project as a means of testing willingness data holders to share genetic in simplest technical context-a query presence specified nucleotide at given position within chromosome. Each participating site (or "beacon") is responsible assuring that genomic are exposed through service only with permission individual whom pertains accordance GA4GH policy standards.While recognizing inference risks associated large-scale...
Differential susceptibilities to various diseases and corresponding metabolite variations have been documented across diverse ethnic populations, but the genetic determinants of these disparities remain unclear. Here, we performed large-scale genome-wide association studies 171 directly quantifiable metabolites from a nuclear magnetic resonance-based metabolomics platform in 10,792 Han Chinese individuals. We identified 15 variant-metabolite associations, eight which were successfully...
Gain-of-function mutations in fibroblast growth factor receptor-3 (FGFR3) lead to several types of human skeletal dysplasia syndromes including achondroplasia, hypochondroplasia and thanatophoric (TD). Currently, there are no effective treatments for these diseases. In this study, we screened, using FGFR3 as a bait, random 12-peptide phage library obtained 23 positive clones that share identical amino acid sequences (VSPPLTLGQLLS), named peptide P3. This had high binding specificity the...
Eicosapentaenoic acid (EPA), a neuroactive omega-3 fatty acid, has been demonstrated to exert neuroprotective effects in experimental models of Parkinson's disease (PD), but the cellular mechanisms protection are unknown. Here, we studied EPA fully differentiated human SH-SY5Y cells and primary mesencephalic neurons treated with MPP(+) . In both in-vitro PD, attenuated an -induced reduction cell viability. also prevented presence electron-dense cytoplasmic inclusions cells. Then, possible...
The generalized linear mixed model (GLMM) is an extension of the (GLM) in which predictor takes random effects into account. Given its power precisely modeling from multiple sources variations, method has been widely used biomedical computation, for instance genome-wide association studies (GWASs) that aim to detect genetic variance significantly associated with phenotypes such as human diseases. Collaborative GWAS on large cohorts patients across institutions often impeded by privacy...
Background. Retinoblastoma (RB) and transforming growth factor-β1 (TGF-β1) are important tumor-related factors. Methods. A series of 30 EBV-associated gastric carcinoma (EBVaGC) 38 matched EBV-negative (EBVnGC) tissues were examined for the promoter methylation RB by methylation-specific PCR (MSP) method. The expression TGF-β1 in was detected immunohistochemistry. Results. rate gene EBVaGC EBVnGC 80.0% (24/30) 50.0% (19/38), respectively. difference between significant (χ(2) = 6.490, P...
// Xiaowei Zhang 1, * , Weijian Guo Xiaofeng Wang 1 Xinyang Liu Mingzhu Huang Lu Gan Yufan Cheng Jin Li 2 Department of Medical Oncology, Fudan University Shanghai Cancer Center, College, University, Shanghai, China Tianyou Hospital Tongji These authors contributed equally to this work Correspondence to: Li, e-mail: fudanlijin@163.com Keywords: Bmi-1, RNA interference, gastric cancer, cancer stem cell Received: July 20, 2015 Accepted: February 15, 2016 Published: March 18, ABSTRACT Bmi-1 is...
Variety testing is an indispensable and essential step in the process of creating new improved varieties from breeding to adoption. The performance can be compared evaluated based on multi-trait data multi-location variety tests multiple years. Although high-throughput phenotypic platforms have been used for observing some specific traits, manual phenotyping still widely used. efficient management large amounts a significant problem crop testing. This study reports test platform (VTP) that...
Abstract Motivation The availability of human genomic data, together with the enhanced capacity to process them, is leading transformative technological advances in biomedical science and engineering. However, public dissemination such data has been difficult due privacy concerns. Specifically, it shown that presence a subject case group can be inferred from shared summary statistics group, e.g. allele frequencies, or even presence/absence genetic variants (e.g. by Beacon project) group....
There are many plant species belonging to the genus Buxus . The taxonomy in is far more confusing, especially endemic Chinese pearl boxwood ( sinica var. parvifolia ), a rare endangered China, which remains controversial phylogenetics and classification yet. In this research, we chose five populations of ) analyze rDNA ITS sequences. By combining other nine reported GenBank using sequence Pachysandra terminalis as reference, did alignment analysis for sequences 18 genus. results indicated...
The design of breeding programs is crucial for maximizing economic gains. Simulation provides the most efficient measures to test these programs, as real-world trials are often costly and time-consuming. We developed GOplan, a comprehensive user-friendly R package designed develop animal considering pure-bred populations crossbreeding systems. Compared other traditional simulators, it has mainstream frameworks, which streamline modeling, use Gene Flow Bayesian optimization methods enhance...