David Lloyd
A5069964511- Kawasaki Disease and Coronary Complications
- Genomics and Rare Diseases
- Cancer Genomics and Diagnostics
- Coronary Artery Anomalies
- Diabetes and associated disorders
- Privacy-Preserving Technologies in Data
- Genomic variations and chromosomal abnormalities
- Mechanical Circulatory Support Devices
- Monoclonal and Polyclonal Antibodies Research
- Glycosylation and Glycoproteins Research
- Bacterial Infections and Vaccines
- Biomedical Ethics and Regulation
- Mitochondrial Function and Pathology
- Diabetes Management and Research
- Streptococcal Infections and Treatments
- Vasculitis and related conditions
- Medical Imaging and Pathology Studies
- Genetic and Kidney Cyst Diseases
- Trypanosoma species research and implications
- Cardiac Structural Anomalies and Repair
- DNA and Biological Computing
- Parathyroid Disorders and Treatments
- Photosynthetic Processes and Mechanisms
- Pneumonia and Respiratory Infections
- Abdominal Trauma and Injuries
Miller Children's & Women's Hospital
2021
Emory University
2016-2019
European Bioinformatics Institute
2016-2018
Wellcome Trust
2016
Wellcome Sanger Institute
2016
Children's Healthcare of Atlanta
2007-2016
Hull Royal Infirmary
2012
We introduce PRINCESS, a privacy-preserving international collaboration framework for analyzing rare disease genetic data that are distributed across different continents. PRINCESS leverages Software Guard Extensions (SGX) and hardware trustworthy computation. Unlike traditional model, where individual-level patient DNA physically centralized at single site, performs secure computation over encrypted data, fulfilling institutional policies regulations protected health information.To...
Although intravenous immunoglobulin (IVIG) is effective therapy for Kawasaki disease, 10-20% of patients have recrudescent fever as a sign persistent inflammation and require additional treatment. We aimed to compare infliximab with second infusion IVIG treatment resistant disease.In this multicentre comparative effectiveness trial, (aged 4 weeks 17 years) disease at least 36 h after completion their first were recruited from 30 hospitals across the USA. Patients randomly assigned (1:1) (2...
The Global Alliance for Genomics and Health (GA4GH) created the Beacon Project as a means of testing willingness data holders to share genetic in simplest technical context-a query presence specified nucleotide at given position within chromosome. Each participating site (or "beacon") is responsible assuring that genomic are exposed through service only with permission individual whom pertains accordance GA4GH policy standards.While recognizing inference risks associated large-scale...
<h3>Importance</h3> Public health measures implemented during the COVID-19 pandemic had widespread effects on population behaviors, transmission of infectious diseases, and exposures to environmental pollutants. This provided an opportunity study how these factors potentially influenced incidence Kawasaki disease (KD), a self-limited pediatric vasculitis unknown etiology. <h3>Objectives</h3> To examine change in KD across United States evaluate whether public affected prevalence KD....
Delayed diagnosis of Kawasaki disease (KD) may lead to serious cardiac complications. We sought create and test the performance a natural language processing (NLP) tool, KD-NLP, in identification emergency department (ED) patients for whom KD should be considered.We developed an NLP tool that recognizes diagnostic criteria based on standard clinical terms medical word usage using 22 pediatric ED notes augmented by Unified Medical Language System vocabulary. With high suspicion defined as...
The Global Alliance for Genomics and Health (GA4GH) proposes a data access policy model-"registered access"-to increase improve to requiring an agreement basic terms conditions, such as the use of DNA sequence health in research. A registered would enable range categories users gain access, starting with researchers clinical care professionals. It also facilitate general reuse but within bounds consent restrictions other ethical obligations. In piloting Scientific Demonstration sharing...
To report the first study of temelimab, a monoclonal antibody neutralizing pathogenic human endogenous retrovirus type W envelope, in patients with 1 diabetes (T1D).This double-blind, placebo-controlled, randomized clinical trial recruited adult T1D within 4 years postdiagnosis and remaining C-peptide secretion. Sixty-four were (2:1) to monthly temelimab 6 mg/kg or placebo during 24 weeks followed by 24-week, open-label extension, which all received temelimab. The primary objective was...
Kawasaki disease (KD) is a systemic vasculitis condition with relatively unknown etiology. First described in 1967 by Tomisaku Japan, KD has come to be widely diagnosed every region of the world. The high prevalence children ages 6 months 5 years, particularly those Japanese descent. Patients often present fever, rash, lymphadenopathy, and conjunctival injections, but there no diagnostic test for KD. This paper presents data from our registry including 99 patients emphasis on cardiopathy....
<ns4:p>Copy number variations (CNVs) are major causative contributors both in the genesis of genetic diseases and human neoplasias. While “High-Throughput” sequencing technologies increasingly becoming primary choice for genomic screening analysis, their ability to efficiently detect CNVs is still heterogeneous remains be developed. The aim this white paper provide a guiding framework future contributions ELIXIR’s recently established <ns4:italic>h</ns4:italic><ns4:italic>uman CNV Community,...
A 74-year-old gentleman presented with an acute onset of confusion and agitation. His symptoms were so severe that he had to be sedated intubated for CT scan. All investigations unremarkable, except a low serum phosphate. He was treated intravenous phosphate his improved in line the rise By discharge, returned previous state health. The cause hypophosphataemia not apparent; we have asked general practitioner monitor