A5030731998- Genomics and Phylogenetic Studies
- Genetics, Bioinformatics, and Biomedical Research
- Bioinformatics and Genomic Networks
- Biomedical Text Mining and Ontologies
- RNA and protein synthesis mechanisms
- Gene expression and cancer classification
- Paleontology and Stratigraphy of Fossils
- Scientific Computing and Data Management
- Geology and Paleoclimatology Research
- Research Data Management Practices
- Chromosomal and Genetic Variations
- Semantic Web and Ontologies
- RNA Research and Splicing
- Genetic Mapping and Diversity in Plants and Animals
- Geological Studies and Exploration
- Genomics and Chromatin Dynamics
- Gene Regulatory Network Analysis
- RNA modifications and cancer
- Machine Learning in Bioinformatics
- Isotope Analysis in Ecology
- Genomics and Rare Diseases
- Bacteriophages and microbial interactions
- Evolution and Paleontology Studies
- Cell Image Analysis Techniques
- Genetic Neurodegenerative Diseases
University of Ljubljana
2021-2024
Florida Atlantic University
2021-2024
University of the West of England
2023
The University of Texas Health Science Center at Houston
2023
University Hospital of Hartlepool
2022
University Hospital of North Tees
2022
Elixir Medical (United States)
2020
Earlham Institute
2016-2019
Wellcome Trust
2010-2019
Norwich Research Park
2016-2017
The mouse inbred line C57BL/6J is widely used in genetics and its genome has been incorporated into many genetic reference populations. More recently large initiatives such as the International Knockout Mouse Consortium (IKMC) are using C57BL/6N strain to generate null alleles for all genes. Hence both strains now studies. Here we perform a comprehensive genomic phenotypic analysis of two identify differences that may influence their underlying mechanisms.We undertake sequence comparisons...
During the Late Cretaceous (94–64 Ma) sea level was up to 650 m higher than at start of Albian, when it perhaps about same as is today. Facies analysis in both Western Interior USA and NW Europe reveals simultaneous major oscillations that controlled principal transgressions regressions except regions rapid contemporaneous tectonics. The peak Early Turonian, Coniacian, Middle Santonian Campanian, probably recognisable world-wide, involved rises rates 10–90 per m.y. are more difficult...
In this, the first of three papers, we present sequence ribosomal RNA (rRNA) genes Drosophila melanogaster. The gene regions D. melanogaster rDNA encode four individual rRNAs: 18S (1,995 nt), 5.8S (123 2S (30 and 28S (3,945 nt). DNA (rDNA) repeat is AT rich (65.9% overall), with spacers being particularly rich. Analysis simplicity reveals that, in contrast to intergenic spacer (IGS) external transcribed (ETS), most rRNA have been refractory action slippage-like events, exception expansion...
Abstract The mouse is an important model of human genetic disease. Describing phenotypes mutant mice in a standard, structured manner that will facilitate data mining major challenge for bioinformatics. Here we describe novel, compositional approach to this problem which combines core ontologies from variety sources. This produces framework with greater flexibility, power and economy than previous approaches. We discuss some the issues raises.
We sequenced the mitochondrial DNA D-loop regions from two cetacean species and compared these with published sequences of several other mammalian species, including one cetacean. Nucleotide substitution rates, sequence simplicity, possible open reading frames (ORFs), potential RNA secondary structure were investigated. The rate is an order magnitude lower than would be expected on basis reports human variation in this region but are consistent interspecific primate rodent estimates rates...
This paper examines the effects of DNA sequence evolution on RNA secondary structures and compensatory mutations. Models Drosophila melanogaster 18S ribosomal (rRNA) complex between 2S, 5.8S, 28S rRNAs have been drawn basis comparative energetic criteria. The overall AU richness D. allows resolution some ambiguities in both large rRNAs. Comparison expansion segment V2 rRNA with same region three other species tsetse fly (Glossina morsitans morsitans) us to distinguish two models for...
Despite existing guidelines on access to data and bioresources, good practice is not widespread. A meeting of mouse researchers in Rome proposes ways promote a culture sharing.
Abstract Low complexity regions (LCRs) in protein sequences are characterized by a less diverse amino acid composition compared to typically observed sequence diversity. Recent studies have shown that LCRs may co-occur with intrinsically disordered regions, highly conserved many organisms, and often play important roles functions diseases. In previous decades, several methods been developed identify or bias, but most of them as stand-alone applications currently there is no web-based tool...
This paper is concerned with the chronostratigraphy of Cretaceous System. It represents a compilation proposals that have resulted from joint efforts three working groups Subcommission on Stratigraphy, as presented at symposium in Copenhagen 1983. The are those on: Pre-Albian, Albian-Turonian, and Coniacian-Maastrichtian.
The set of "expansion segments" any eukaryotic 26S/28S ribosomal RNA (rRNA) gene is responsible for the bulk difference in length between prokaryotic 23S rRNA and gene. expansion segments are also interspecific fluctuations during evolution. They show a consistent bias base composition species; example, they AT rich Drosophila melanogaster GC vertebrate species. Dot-matrix comparisons sets reveal high similarities members within 28S species, contrast to little or spurious similarity that...
Amino acid repeats (AARs) are common features of protein sequences. They often evolve rapidly and involved in a number human diseases. also show significant associations with particular Gene Ontology (GO) functional categories, particularly transcription, suggesting they play some role function. It has been suggested recently that AARs the evolution intrinsically unstructured regions (IURs) proteins. We investigate relationship between AAR frequency their localization within proteins based...
Abstract Machine learning algorithms efficiently trained on intrusion detection datasets can detect network traffic capable of jeopardizing an information system. In this study, we use the CSE-CIC-IDS2018 dataset to investigate ensemble feature selection performance seven classifiers. is big data (about 16,000,000 instances), publicly available, modern, and covers a wide range realistic attack types. Our contribution centered around answers three research questions. The first question is,...
DNA sequences of the first ribosomal internal transcribed spacer (ITS1) were isolated from 10 ladybird beetle species (Coleoptera: Coccinellidae) representing four subfamilies (Coccinellinae, Chilocorinae, Scymninae, and Coccidulinae). The spacers ranged in length 791 to 2,572 bp, thereby including one longest ITS1s exhibiting most extreme cases ITS1 size variation eukaryotes recorded date. causes therefore analyzed. Almost no putatively homologous sequence similarities identified for taxa...