A5008776339- Pharmaceutical and Antibiotic Environmental Impacts
- Wastewater Treatment and Nitrogen Removal
- Antibiotic Resistance in Bacteria
- Water Treatment and Disinfection
- Microbial Community Ecology and Physiology
- Environmental Toxicology and Ecotoxicology
- Antibiotic Use and Resistance
- Pesticide and Herbicide Environmental Studies
- Gene expression and cancer classification
- Analytical chemistry methods development
- Chemistry and Chemical Engineering
- Effects and risks of endocrine disrupting chemicals
- Antibiotics Pharmacokinetics and Efficacy
- Microbial Fuel Cells and Bioremediation
- Metabolomics and Mass Spectrometry Studies
- Mass Spectrometry Techniques and Applications
- Molecular Biology Techniques and Applications
- Genetics, Bioinformatics, and Biomedical Research
- Environmental Chemistry and Analysis
- Microbial bioremediation and biosurfactants
- Computational Drug Discovery Methods
- Research Data Management Practices
- Toxic Organic Pollutants Impact
- Science, Research, and Medicine
- Bacteriophages and microbial interactions
AstraZeneca (United Kingdom)
2015-2024
University of Warwick
2017-2020
Newcastle University
2018-2020
AstraZeneca (Brazil)
2005-2019
Brixham Community Hospital
2002-2013
AstraZeneca (India)
2003
Cornell University
2003
National Environmental Engineering Research Institute
2003
University of Wales
1993-1997
Leicester General Hospital
1987
There is growing understanding that the environment plays an important role both in transmission of antibiotic resistant pathogens and their evolution. Accordingly, researchers stakeholders world-wide seek to further explore mechanisms drivers involved, quantify risks identify suitable interventions. a clear value establishing research needs coordinating efforts within across nations order best tackle this global challenge. At international workshop late September 2017, scientists from 14...
The presence of pharmaceuticals in the environment is a growing global concern and although environmental risk assessment required for approval new drugs Europe USA, adequacy current triggers effects-based assessments has been questioned. To provide comprehensive analysis all regulatory compliant aquatic ecotoxicity data evaluate to facilitate development more efficient approaches toxicity testing. Publicly-available targeting human proteins was compiled together with pharmacological...
Abstract Determining the selective potential of antibiotics at environmental concentrations is critical for designing effective strategies to limit selection antibiotic resistance. This study determined minimal (MSCs) macrolide and fluoroquinolone included on European Commissionʼs Water Framework Directive’s priority hazardous substances Watch List. The macrolides demonstrated positive ermF 1–2 orders magnitude greater (>500 <750 µg/L) than measured (MECs). Ciprofloxacin illustrated...
ADVERTISEMENT RETURN TO ISSUEPREVVIEWPOINTNEXTToxicogenomics in Regulatory EcotoxicologyGerald T. Ankley, George P. Daston, Sigmund J. Degitz, Nancy D. Denslow, Robert A. Hoke, Sean W. Kennedy, Ann L. Miracle, Edward Perkins, Jason Snape, Donald E. Tillitt, Charles R. Tyler, and VersteegCite this: Environ. Sci. Technol. 2006, 40, 13, 4055–4065Publication Date (Web):July 1, 2006Publication History Published online1 July 2006Published inissue 1...
Microorganisms maintain the biosphere by catalyzing biogeochemical processes, including biodegradation of organic chemical pollutants. Yet seldom have responsible agents and their respective genes been identified. Here we used field-based stable isotopic probing (SIP) to discover a group bacteria for in situ metabolism an environmental pollutant, naphthalene. We released 13 C-labeled naphthalene contaminated study site trace flow pollutant carbon into naturally occurring microbial community....
Our goal was to develop a field soil biodegradation assay using 13C-labeled compounds and identify the active microorganisms by analyzing 16S rRNA genes in soil-derived DNA. approach sought minimize microbiological artifacts caused physical and/or nutritional disturbance of associated with sampling laboratory incubation. The new field-based involved release (glucose, phenol, caffeine, naphthalene) plots, installation open-bottom glass chambers that covered soil, analysis samples headspace...
Autotrophic ammonia-oxidising bacteria (AOB) are a crucial component of the microbial communities nitrifying wastewater treatment systems. Nitrification is known to occur in reactors different configuration, but whether AOB design unknown. We compared diversity and community structure betaproteobacterial two full-scale - biological aerated filter (BAF) trickling receiving same wastewater. Polymerase chain reaction (PCR) 16S ribosomal RNA (rRNA) gene fragments with AOB-selective primers was...
In this commentary we present the findings from an international consortium on fish toxicogenomics sponsored by U.K. Natural Environment Research Council (Fish Toxicogenomics-Moving into Regulation and Monitoring, held 21-23 April 2008 at Pacific Environmental Science Centre, Vancouver, BC, Canada).The government agencies, academia, industry addressed three topics: progress in ecotoxicogenomics, regulatory perspectives roadblocks for practical implementation of risk assessment, dealing with...
ABSTRACT Recent research has demonstrated that selection for antibiotic resistance occurs at very low concentrations in single-species experiments, but the relevance of these findings when species are embedded complex microbial communities is unclear. We show strength naturally occurring alleles a community remains constant from subinhibitory to above clinically relevant concentrations. Selection increases with concentration before reaching plateau where over 2-order-magnitude range. This...
In 2016, the United Nations declared need for urgent action to combat global threat of antimicrobial resistance (AMR). support this effort, pharmaceutical industry has committed measures aimed at improving stewardship antibiotics both within and outside clinic. Notably, a group companies collaborated specifically address concerns related antibiotic residues being discharged from manufacturing sites. addition developing framework minimum environmental expectations manufacturers, science-based...
Environmental persistence is an important property that can enhance the potential of a chemical substance to exert adverse effects and be transported remote environments. The organic compounds governed by rates at which they are removed biological processes, such as biodegradation, hydrolysis, atmospheric oxidation, photolysis. workgroup in recent Society Toxicology Chemistry (SETAC) Pellston workshop (Pensacola, FL, USA, January 2008) focused on evaluating environmental media (air, water,...
Abstract β‐Adrenergic receptor blockers (β‐blockers) are applied to treat high blood pressure, ischemic heart disease, and rhythm disturbances. Due their widespread use limited human metabolism, β‐blockers widely detected in sewage effluents surface waters. receptors have been characterized fish other aquatic animals, so it can be expected that physiological processes regulated by these wild animals may affected the presence of β‐blockers. Because ecotoxicological data on scarce, was decided...
Ecopharmacovigilance (EPV) is a developing science and it currently very unclear what might mean in practice. We have performed comparison between pharmacovigilance (PV) EPV identified that there are similarities, but also some important differences must be considered before any practical implementation of EPV. The biggest difference greatest challenge concerns signal detection the environment difficulty identifying cause effect. reflect on dramatic vulture decline Asia, which was caused by...