A5053002372- Metabolomics and Mass Spectrometry Studies
- Water Treatment and Disinfection
- Pharmaceutical and Antibiotic Environmental Impacts
- Spectroscopy and Chemometric Analyses
- Water Quality Monitoring and Analysis
- Environmental Toxicology and Ecotoxicology
- Fish Ecology and Management Studies
- Advanced Chemical Sensor Technologies
- Reproductive biology and impacts on aquatic species
- Chemical Analysis and Environmental Impact
- Effects and risks of endocrine disrupting chemicals
- Analytical Chemistry and Chromatography
- Aquaculture Nutrition and Growth
- Spectroscopy Techniques in Biomedical and Chemical Research
- Toxic Organic Pollutants Impact
- Mercury impact and mitigation studies
- Muon and positron interactions and applications
- Isotope Analysis in Ecology
- Hormonal and reproductive studies
- Physiological and biochemical adaptations
- Liquid Crystal Research Advancements
- Pharmacological Effects and Assays
- Chemical Thermodynamics and Molecular Structure
- Biochemical and Structural Characterization
- Electrochemical Analysis and Applications
Environmental Protection Agency
2015-2025
NCCOS Hollings Marine Laboratory
2008
University of Birmingham
2008
Imperial College London
2008
Research Triangle Park Foundation
2007
University of Georgia
1985-1999
Using a combination of spectral identification techniquesgas chromatography coupled with low- and high-resolution electron-impact mass spectrometry (GC/EI-MS), chemical ionization (GC/CI-MS), infrared spectroscopy (GC/IR)we identified many drinking water disinfection byproducts (DBPs) formed by ozone combinations chlorine chloramine. Many these DBPs have not been previously reported. In addition to conventional XAD resin extraction, both pentafluorobenzylhydroxylamine (PFBHA) methylation...
Metabolomics datasets, by definition, comprise of measurements large numbers metabolites. Both technical (analytical) and biological factors will induce variation within these that is not consistent across all Consequently, criteria are required to assess the reproducibility metabolomics datasets derived from detected Here we calculate spectrum-wide relative standard deviations (RSDs; also termed coefficient variation, CV) for ten spanning a variety sample types mammals, fish, invertebrates...
In this commentary we present the findings from an international consortium on fish toxicogenomics sponsored by U.K. Natural Environment Research Council (Fish Toxicogenomics-Moving into Regulation and Monitoring, held 21-23 April 2008 at Pacific Environmental Science Centre, Vancouver, BC, Canada).The government agencies, academia, industry addressed three topics: progress in ecotoxicogenomics, regulatory perspectives roadblocks for practical implementation of risk assessment, dealing with...
Several fundamental requirements must be met so that NMR-based metabolomics and the related technique of metabonomics can formally adopted into environmental monitoring chemical risk assessment. Here we report an intercomparison exercise which has evaluated effectiveness 1H NMR to generate comparable data sets from environmentally derived samples. It focuses on laboratory practice follows sample collection metabolite extraction, specifically final stages preparation, (500, 600, 800 MHz),...
Using a combination of mass spectrometry and infrared spectroscopy, disinfection byproducts were identified in ozonated drinking water containing elevated bromide levels treated with secondary chlorine or chloramine. Only one brominated byproductdibromoacetonitrilewas found the only ozone. This compound was three treatment rounds also present untreated, raw but at 20 times lower than water. Many more when chloramine applied after ozonation. A number these have not been reported previously....
The application of 'omics tools to biologically based monitoring and surveillance aquatic environments shows considerable promise for complementing chemical in ecological risk assessments. However, few the current approaches offer ability sample ecologically relevant species (e.g., fish) a way that produces minimal impact on health organism(s) under study. In study we employ liquid chromatography tandem mass spectrometry (LC-MS/MS) assess potential skin mucus-based metabolomics minimally...
Perchlorate has contaminated groundwater, drinking water, and soils at several locations in the United States. The primary source of contamination sites that have been investigated to date seems be from industrial military operations use perchlorate as an oxidizing agent. However, recent examination fertilizers fertilizer components showed is present levels up 0.84 wt %. These preliminary results suggest could a for accumulation food chain.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMultispectral Identification of Chlorine Dioxide Disinfection Byproducts in Drinking WaterSusan D. Richardson, Alfred Thruston, Timothy W. Collette, Kathleen Schenck. Patterson, Benjamin Lykins, George. Majetich, and Yong. ZhangCite this: Environ. Sci. Technol. 1994, 28, 4, 592–599Publication Date (Print):April 1, 1994Publication History Published online1 May 2002Published inissue 1 April...
Due to concern over the presence of trihalomethanes (THMs) and other chlorinated byproducts in drinking water, alternative disinfection methods are being explored. One treatment currently evaluated for potential use with small systems (less than 3300 people) is titanium dioxide (TiO2) photocatalysis. Using a combination unconventional GC/MS GC/FT-IR techniques, we identified organic (DBPs) formed by photocatalytic water TiO2 ultraviolet (UV) light. The identifications also reflect effects...
Chlorpyrifos (CP) was used as a model compound to develop experimental methods and prototype modeling tools forecast the fate of organophosphate (OP) pesticides under drinking water treatment conditions. CP found rapidly oxidize chlorpyrifos oxon (CPO) in presence free chlorine. The primary oxidant is hypochlorous acid (HOCl), kr = 1.72 (±0.68) × 106 M-1h-1. Thus, oxidation more rapid at lower pH (i.e., below pKa HOCl 7.5). At elevated pH, both CPO are susceptible alkaline hydrolysis degrade...
1H NMR spectroscopy was used to profile metabolite changes in the livers of fathead minnows (Pimephales promelas) exposed synthetic estrogen 17α-ethynylestradiol (EE2) via a continuous flow water exposure. Fish were either 10 or 100 ng EE2/L for 8 days, followed by an day depuration phase. Livers collected after days 1, 4, and exposure, at end Analysis polar extracts liver revealed greater impact EE2 on males than females, with profiles former assuming similarities those females (i.e.,...
Organisms are exposed to ever-changing complex mixtures of chemicals over the course their lifetime. The need more comprehensively describe this exposure and relate it adverse health effects has led formulation exposome concept in human toxicology. Whether utility context environmental hazard risk assessment not been discussed detail. In Critical Perspective, we propose-by analogy exposome-to define eco-exposome as totality internal (anthropogenic natural chemicals, biotransformation...
The ability to focus on the most biologically relevant contaminants affecting aquatic ecosystems can be challenging because toxicity-assessment programs have not kept pace with growing number of requiring testing. Because it has proven effective at assessing biological impacts potentially toxic contaminants, profiling endogenous metabolites (metabolomics) may help screen out a lower likelihood eliciting impacts, thereby prioritizing important contaminants. authors present results from study...
The speciation of aqueous free chlorine above pH 5 is a well-understood equilibrium H 2 O + HOCl ⇌ OCl − 3 with p K 7.5. However, the identity another very potent oxidant present at low (below 5) has been attributed by some researchers to Cl (aq) and others . We have conducted series experiments designed ascertain which these two species correct. First, using Raman spectroscopy, we found that an unlikely because “apparent ” increases monotonically from 1.25 2.11 as analytical concentration...
Abstract The impact of exposure by water to a model androgen, 17β-trenbolone (TRB), was assessed in fathead minnows using an integrated molecular approach. This included classical measures endocrine such as impacts on testosterone (T), 17β-estradiol (E2), and vitellogenin (VTG) concentrations plasma, well determination effects the hepatic metabolome proton nuclear magnetic resonance spectroscopy. In addition, rates production T E2 ovary explants were measured, changes number ovarian gene...
Male and female fathead minnows (Pimephales promelas, FHM) were exposed via water to 20 or 200 μg/L of cyproterone acetate (CA), a model androgen receptor (AR) antagonist. FHM also 500 ng/L 17β-trenbolone (TB), AR agonist, mixtures TB with both concentrations CA. The urine metabolite profile (as measured by 1H NMR spectroscopy) male the high concentration CA was markedly different from that controls, this difference less for males coexposed associated TB+CA mixture. exposure alone had almost...
There is increasing demand for the implementation of effects-based monitoring and surveillance (EBMS) approaches in Great Lakes Basin to complement traditional chemical monitoring. Herein, we describe an ongoing multiagency effort develop implement EBMS tools, particularly with regard potentially toxic chemicals assessing Areas Concern (AOCs), as envisioned by Restoration Initiative (GLRI). Our strategy includes use both targeted open-ended/discovery techniques, appropriate amount...