Christoph Lengger
A5086489585- Biomedical Text Mining and Ontologies
- Single-cell and spatial transcriptomics
- Gene expression and cancer classification
- Adipose Tissue and Metabolism
- Carcinogens and Genotoxicity Assessment
- Bioinformatics and Genomic Networks
- RNA modifications and cancer
- Animal testing and alternatives
- Biotin and Related Studies
- Scientific Computing and Data Management
- Genetic Mapping and Diversity in Plants and Animals
- Congenital heart defects research
- Animal Genetics and Reproduction
- Advanced Proteomics Techniques and Applications
- Cell Image Analysis Techniques
- Hedgehog Signaling Pathway Studies
- Folate and B Vitamins Research
- Molecular Biology Techniques and Applications
- Animal Behavior and Welfare Studies
- Craniofacial Disorders and Treatments
- bioluminescence and chemiluminescence research
- DNA Repair Mechanisms
- Viral Infectious Diseases and Gene Expression in Insects
- Gene Regulatory Network Analysis
- Cardiomyopathy and Myosin Studies
Helmholtz Zentrum München
2009-2022
Institute of Groundwater Ecology
2006-2022
Mary Lyon Centre at MRC Harwell
2009
Institut Clinique de la Souris
2009
Center for Environmental Health
2005
Forschungsinstitut für Kinderernährung
2000-2002
Witten/Herdecke University
2000
Clinical presentation of congenital heart disease is heterogeneous, making identification the disease-causing genes and their genetic pathways mechanisms action challenging. By using in vivo electrocardiography, transthoracic echocardiography microcomputed tomography imaging to screen 3,894 single-gene-null mouse lines for structural functional cardiac abnormalities, here we identify 705 with arrhythmia, myocardial hypertrophy and/or ventricular dilation. Among these genes, 486 have not been...
The broad aim of biomedical science in the postgenomic era is to link genomic and phenotype information allow deeper understanding processes leading from changes altered disease. EuroPhenome project (http://www.EuroPhenome.org) a comprehensive resource for raw annotated high-throughput phenotyping data arising projects such as EUMODIC. EUMODIC gathering EMPReSSslim pipeline (http://www.empress.har.mrc.ac.uk/) which performed on inbred mouse strains knock-out lines EUCOMM project. interface...
Schizophrenia is a complex psychiatric disorder with genetic and phenotypic heterogeneity. Accumulating rare genome-wide association study (GWAS) common risk variant information has yet to yield robust mechanistic insight. Leveraging large-scale gene deletion mouse phenomic data thus potential functionally interrogate prioritize human disease genes. To this end, we applied cross-species network-based approach parse an extensive set (188 genes) associated disrupted prepulse inhibition (PPI),...
The German Mouse Clinic (GMC) is a large scale phenotyping center where mouse mutant lines are analyzed in standardized and comprehensive way. result an almost complete picture of the phenotype line--a systemic view. At GMC, expert scientists from various fields research work close cooperation with clinicians side by at one location. screens comprise following areas: allergy, behavior, clinical chemistry, cardiovascular analyses, dysmorphology, bone cartilage, energy metabolism, eye vision,...
Under the label of German Mouse Clinic (GMC), a concept has been developed and implemented that allows better understanding human diseases on pathophysiological molecular level. This includes crosstalk between different organs, pleiotropy genes, systemic impact envirotypes drugs. In GMC, experts from various fields mouse genetics physiology, in close collaboration with clinicians, work side by under one roof. The GMC is an open-access platform for scientific community providing phenotypic...
Abstract The collaborative cross (CC) is a large panel of mouse-inbred lines derived from eight founder strains (NOD/ShiLtJ, NZO/HILtJ, A/J, C57BL/6J, 129S1/SvImJ, CAST/EiJ, PWK/PhJ, and WSB/EiJ). Here, we performed comprehensive comparative phenotyping screening to identify phenotypic differences similarities between the strains. In total, more than 300 parameters including allergy, behavior, cardiovascular, clinical blood chemistry, dysmorphology, bone cartilage, energy metabolism, eye...
Over recent years, the use of individually ventilated cage (IVC) rack systems in laboratory rodent facilities has increased. Since every an IVC may be assumed to a separate microbiological unit, comprehensive monitoring animals kept IVCs become challenging task, which addressed by appropriate sentinel mice. Traditionally, these sentinels have been exposed soiled bedding but more recently, concept exposure exhaust air considered. The work reported here was aimed firstly at testing efficiency...
Abstract Calcium signalling plays a critical role in the pathogenesis of heart failure. Here we describe cardiac protein named Myoscape/FAM40B/STRIP2, which directly interacts with L-type calcium channel. Knockdown Myoscape cardiomyocytes decreases transients associated smaller Ca 2+ amplitudes and lower diastolic content. Likewise, channel currents are significantly diminished on ablation, downregulation reduces contractility cardiomyocytes. Conversely, overexpression increases global...
Abstract Background Large-scale, comprehensive and standardized high-throughput mouse phenotyping has been established as a tool of functional genome research by the German Mouse Clinic others. In all these projects, vast amounts data are continuously generated need to be stored, prepared for data-mining procedures eventually made publicly available. Thus, central storage integrated management phenotype data, genotype metadata linked external highly important. Requirements most probably...
Paladin (Pald1, mKIAA1274 or x99384) was identified in screens for vascular-specific genes and is a putative phosphatase. has also been proposed to be involved various biological processes such as insulin signaling, innate immunity neural crest migration. To determine the role of paladin we have now characterized Pald1 knock-out mouse broad array behavioral, physiological biochemical tests. Here, show that female, but not male, heterozygous homozygous mice display an emphysema-like histology...
The vertebrate Scube (Signal peptide, CUB, and EGF-like domain-containing protein) family consists of three independent members, Scube1-3, which encode secreted cell surface-associated membrane glycoproteins. Limited information about the general function this gene is available, their roles during adulthood. Here, we present first Scube3 mutant mouse line (Scube3N294K/N294K), clearly shows phenotypic alterations by carrying a missense mutation in exon 8, thus contributes to our understanding...
Abstract Diabetes mellitus is a group of disorders characterized by prolonged high levels circulating blood glucose. Type 1 diabetes caused decreased insulin production in the pancreas whereas type 2 may develop due to obesity and lack exercise; it begins with resistance whereby cells fail respond properly also progress levels. The brain an important target for insulin, there great interest understanding how affects brain. In addition direct effects on brain, impact through modulation...
Animal models resembling human mutations are valuable tools to research the features of complex craniofacial syndromes. This is first report on a viable dominant mouse model carrying non-synonymous sequence variation within endothelin receptor type A gene (Ednra c.386A>T, p.Tyr129Phe) derived by an ENU mutagenesis program. The identical amino acid substitution was reported recently as disease causing in three individuals with mandibulofacial dysostosis alopecia (MFDA, OMIM 616367) syndrome....
Figure 1.In Fig. 1f, due to a production error, the large panels for Ap4e1 -/-mutant and control were interchanged have been restored.In 1d,