A5036810185- Particle physics theoretical and experimental studies
- High-Energy Particle Collisions Research
- Particle Detector Development and Performance
- Quantum Chromodynamics and Particle Interactions
- Dark Matter and Cosmic Phenomena
- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- CNS Lymphoma Diagnosis and Treatment
- Computational Physics and Python Applications
- Cosmology and Gravitation Theories
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Lung Cancer Treatments and Mutations
- Distributed and Parallel Computing Systems
- Glioma Diagnosis and Treatment
- Black Holes and Theoretical Physics
- Neutrino Physics Research
- Psychiatric care and mental health services
- Cancer Treatment and Pharmacology
- Health and Medical Studies
- Brain Metastases and Treatment
- Advanced Data Storage Technologies
- Mental Health Treatment and Access
- Colorectal Cancer Treatments and Studies
- Astrophysics and Cosmic Phenomena
- Medical Practices and Rehabilitation
Helmholtz Zentrum München
2005-2024
Praxis für Hämatologie und Onkologie
2009-2024
German Center for Lung Research
2015-2024
Humboldt-Universität zu Berlin
2012-2023
Durham University
2016-2023
Deutsches Elektronen-Synchrotron DESY
2022
Brookhaven National Laboratory
2022
ERN GUARD-Heart
2022
University Hospital Münster
2022
Fraunhofer Institute for Material Flow and Logistics
2022
To evaluate response rate, duration, overall survival (OS), and toxicity in primary CNS lymphoma (PCNSL) after systemic intraventricular chemotherapy with deferred radiotherapy.From September 1995 to July 2001, 65 consecutive patients PCNSL (median age, 62 years) were enrolled onto a pilot phase II study evaluating without radiotherapy. A high-dose methotrexate (MTX; cycles 1, 2, 4, 5) cytarabine (ARA-C; 3 6)-based therapy (including dexamethasone, vinca-alkaloids, ifosfamide,...
We present a novel integrator based on normalizing flows which can be used to improve the unweighting efficiency of Monte-Carlo event generators for collider physics simulations. In contrast machine learning approaches surrogate models, our method generates correct result even if underlying neural networks are not optimally trained. exemplify new strategy using example Drell-Yan type processes at LHC, both leading and partially next-to-leading order QCD.
Sherpa is a general-purpose Monte Carlo event generator for the simulation of particle collisions in high-energy collider experiments. We summarize essential features and improvements 2.2 release series, which heavily used generation analysis interpretation LHC Run 1 2 data. highlight decade developments towards ever higher precision particle-collision events.
The Forward Physics Facility (FPF) is a proposal to create cavern with the space and infrastructure support suite of far-forward experiments at Large Hadron Collider during High Luminosity era. Located along beam collision axis shielded from interaction point by least 100 m concrete rock, FPF will house that detect particles outside acceptance existing large LHC observe rare exotic processes in an extremely low-background environment. In this work, we summarize current status plans for FPF,...
This randomized, open-label trial compared the efficacy and safety of adjuvant
To determine the efficacy and safety of a newly developed concomitant administration fludarabine alemtuzumab (FluCam) in patients with relapsed or refractory B-cell chronic lymphocytic leukemia (B-CLL).A total 36 were treated this phase II study (median age, 61.47 years; mean number prior chemotherapies, 2.6; Binet stage C, n = 28). After an initial dose escalation over 3 days, 30 mg mg/m2 administered on consecutive days. Treatment was repeated after 28 days for up to six cycles. Restaging...
In this article we describe Professor, a new program for tuning model parameters of Monte Carlo event generators to experimental data by parameterising the per-bin generator response parameter variations and numerically optimising parameterised behaviour. Simulated analysis is obtained using Rivet toolkit. This paper presents Professor procedure implementation, illustrated with application method tunes Pythia 6 from LEP/SLD Tevatron experiments. These are substantial improvements on existing...
MET is a potential therapeutic target in lung cancer and both tyrosine kinase inhibitors monoclonal antibodies have entered clinical trials. signaling can be activated by various mechanisms, including gene amplification. In this study, we aimed to investigate amplification status adeno- squamous cell carcinomas of the lung. We propose clearly defined scores provide epidemiologic data on cancer.We evaluated prevalence increased copy numbers 693 treatment-naïve cancers FISH, clear cutoff...
Chronic Obstructive Pulmonary Disease (COPD) influences different aspects of patient's health-related quality life (HRQL). While disease-specific HRQL instruments focus on symptoms and functional impairments, generic cover a broader view health. This study compares the EQ-5D-3 L two questionnaires (St.-George's Respiratory Questionnaire (SGRQ-C), COPD Assessment Test (CAT)) in comprehensive spectrum disease grades with particular attention comorbidities assesses discriminative abilities...
First released in 2010, the Rivet library forms an important repository for analysis code, facilitating comparisons between measurements of final state particle collisions and theoretical calculations those states. We give overview Rivet's current design implementation, its uptake preservation physics results, summarise recent developments including propagation MC systematic-uncertainty weights, heavy-ion $ep$ physics, systems detector emulation. In addition, we provide a short user guide...
Event generators like play an important role in physics studies at the Large Hadron Collider (LHC). While they make accurate predictions central region, i.e., pseudorapidities <a:math xmlns:a="http://www.w3.org/1998/Math/MathML" display="inline"><a:mi>η</a:mi><a:mo><</a:mo><a:mn>5</a:mn></a:math>, a disagreement between and measurements forward region <c:math xmlns:c="http://www.w3.org/1998/Math/MathML" display="inline"><c:mi>η</c:mi><c:mo>></c:mo><c:mn>7</c:mn></c:math> has been...
Abstract Myeloproliferative neoplasms (MPN) are associated with a variety of symptoms that severely impact patients’ quality life and ability to perform daily activities. Recent studies showed differences in the perception physician- versus patient-reported symptom burden. However, directly comparing patient- physician-reported ratings lacking. Here, retrospective analysis on burden 3979 MPN patients Bioregistry German Study Group for was conducted intra-individually compare physician...
The 2011 Les Houches workshop was the first to confront LHC data. In two years since previous there have been significant advances in both soft and hard QCD, particularly areas of multi-leg NLO calculations, inclusion those calculations into parton shower Monte Carlos, tuning non-perturbative parameters Carlos. These proceedings describe theoretical that taken place, impact early data, for future development.
Due to the absence of tantalising hints for new physics during LHC's run 1, extension Higgs sector by dimension six operators will provide phenomenological standard searches non-resonant extensions Standard Model. Using all dominant and subdominant production mechanisms at LHC, we compute constraints on physics-relevant in a global correlated fit. We show how far these can be improved channels becoming accessible higher energy luminosity, both through inclusive cross sections as well highly...