A5024387900- Land Use and Ecosystem Services
- Liver Disease Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Adrenal Hormones and Disorders
- Alcohol Consumption and Health Effects
- Conservation, Biodiversity, and Resource Management
- Hormonal Regulation and Hypertension
- Forest Management and Policy
- Eicosanoids and Hypertension Pharmacology
- Pancreatic function and diabetes
- Peroxisome Proliferator-Activated Receptors
- Metabolomics and Mass Spectrometry Studies
- Cardiac Fibrosis and Remodeling
- Urban Green Space and Health
- Diabetes and associated disorders
- Cardiovascular Disease and Adiposity
- Indigenous Knowledge Systems and Agriculture
- Lipid metabolism and biosynthesis
- Rural development and sustainability
- Mast cells and histamine
- Blood Coagulation and Thrombosis Mechanisms
- Urban Agriculture and Sustainability
- Liver physiology and pathology
- Endoplasmic Reticulum Stress and Disease
- Adipokines, Inflammation, and Metabolic Diseases
Technische Universität Dresden
2012-2025
University Hospital Carl Gustav Carus
2019-2023
Emulate (United States)
2020-2021
Abstract The mechanism underlying vasoproliferative retinopathies like retinopathy of prematurity ( ROP ) is hypoxia‐triggered neovascularisation. Nerve growth factor NGF ), a neurotrophin supporting survival and differentiation neuronal cells may also regulate endothelial cell functions. Here we studied the role in pathological retinal angiogenesis course mouse model. Topical application enhanced while intraocular injections anti‐ neutralizing antibody reduced vascularization mice subjected...
Corticosteroids regulate vital processes, including stress responses, systemic metabolism, and blood pressure. Here, we show that corticosteroid synthesis is related to the polyunsaturated fatty acid (PUFA) content of mitochondrial phospholipids in adrenocortical cells. Inhibition rate-limiting enzyme PUFA synthesis, desaturase 2 (FADS2), leads perturbations lipidome diminishes steroidogenesis. Consistently, mitochondria Fads2 −/− mice fed a diet with low concentration are structurally...
Brown adipose tissue (BAT) thermogenesis dissipates energy through heat production and thereby it opposes metabolic disease. It is mediated by mitochondrial membrane uncoupling, yet the mechanisms sustaining potential (ΔΨm) in brown adipocytes are poorly understood. Here we show that isocitrate dehydrogenase (IDH) activity expression of soluble adenylate cyclase 10 (ADCY10), a CO2/bicarbonate sensor residing mitochondria, upregulated BAT cold-exposed mice. IDH inhibition or ADCY10 deficiency...
The hypothalamus-pituitary-adrenal (HPA) axis is activated in response to inflammation leading increased production of anti-inflammatory glucocorticoids by the adrenal cortex, thereby representing an endogenous feedback loop. However, severe reduces responsiveness gland adrenocorticotropic hormone (ACTH), although underlying mechanisms are poorly understood. Here, we show transcriptomic, proteomic, and metabolomic analyses that LPS-induced systemic triggers profound metabolic changes...
NAFLD is initiated by steatosis and can progress through fibrosis cirrhosis to HCC. The RNA binding protein human antigen R (HuR) controls RNAs at the posttranscriptional level; hepatocyte HuR has been implicated in regulation of diet-induced hepatic steatosis. present study aimed understand role development progression HCC.Hepatocyte-specific, HuR-deficient mice control HuR-sufficient were fed either a normal diet or an NAFLD-inducing diet. Hepatic lipid accumulation, inflammation,...
After myocardial infarction the innate immune response is pivotal in clearing of tissue debris as well scar formation, but exaggerated cytokine and chemokine secretion with subsequent leukocyte infiltration also leads to further damage. Here, we address value targeting a previously unknown disintegrin metalloprotease 10 (ADAM10)/CX3CL1 axis regulation neutrophil recruitment early after MI. We show that ADAM10 distinctly upregulated biopsies from patients ischemia-driven cardiomyopathy....
This paper presents, by means of a case study, an approach for how to make use sectoral planning information on forestry in regional planning. Exemplary issues addressed this study were, first, evaluate the conversion existing forests and, second, afforestation agricultural sites, regarding impact these strategies provision ecosystem services at scale. We demonstrate that scenarios planned state forest administration have only minor scale because proportion is too small. As consequence,...
Histamine-induced vascular leakage is a core process of allergic pathologies, including anaphylaxis. Here, we show that glycolysis integral to histamine-induced endothelial barrier disruption and hyperpermeability. Histamine rapidly enhanced in cells via pathway involved histamine receptor 1 phospholipase C beta signaling. Consistently, partial inhibition with 3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one (3PO) prevented hyperpermeability human microvascular cells, by abolishing the...
In Type 1 Diabetes Mellitus (T1DM), leukocyte infiltration of the pancreatic islets and resulting immune-mediated destruction beta cells precede hyperglycemia clinical disease symptoms. this context, role endothelium as a barrier for autoimmunity- inflammation-related is not well studied. Here, we identified Robo4, expressed on endothelial cells, regulator vascular permeability during autoimmune diabetes. Circulating levels Robo4 were upregulated in mice subjected to Multiple Low-Dose...
Abstract Diabetes mellitus is a group of disorders characterized by prolonged high levels circulating blood glucose. Type 1 diabetes caused decreased insulin production in the pancreas whereas type 2 may develop due to obesity and lack exercise; it begins with resistance whereby cells fail respond properly also progress levels. The brain an important target for insulin, there great interest understanding how affects brain. In addition direct effects on brain, impact through modulation...
Abstract Fatty liver disease (FLD), is a major public health burden that affects up to 30% of people in Western countries and leads progressive injury, comorbidities, increased mortality. Key risk factors for developing FLD are obesity alcohol consumption, both which growing prevalence worldwide. There an urgent need human-relevant preclinical models improve our understanding progression steatohepatitis the development sensitive noninvasive diagnostics therapies. Alcohol-induced (ALD)...
Abstract Objective Adrenocortical hormone levels increase in obesity, potentially contributing to development of obesity-associated pathologies. Here we explored whether lipidomic remodeling the adrenal gland could mediate altered adrenocortical steroidogenesis during obesity. Methods Lipidomic analysis was performed glands using shotgun mass spectrometry (MS), and steroid profiling sera by liquid chromatography tandem (LC-MS/MS) from lean obese mice. Gene expression cell populations. The...
Fatty liver disease (FLD) is a major public health burden that affects up to 30% of people in Western countries and leads progressive injury, comorbidities, increased mortality. One risk factor for developing FLD alcohol consumption, which growing prevalence worldwide. There an urgent need human-relevant preclinical models improve our understanding progression steatohepatitis alcoholic (ALD) develop sensitive noninvasive diagnostics therapies general. Here, by leveraging tri-culture human...
Abstract The hypothalamus-pituitary-adrenal (HPA) axis is activated in response to inflammation leading increased production of anti-inflammatory glucocorticoids by the adrenal cortex, thereby representing an endogenous feedback loop. However, severe reduces responsiveness gland adrenocorticotropic hormone (ACTH) although underlying mechanisms are poorly understood. Here, we show transcriptomic, proteomic and metabolomic analyses that LPS-induced systemic triggers profound metabolic changes...
Abstract Background and Purpose The metalloprotease ADAM10 has been implicated in immune regulatory processes, is upregulated response to specific heart pathologies e.g. ischemic failure, elevated serum levels of the substrates CX3CL1 CXCL16 have reported following infarction. causal role cardiovascular diseases, however, not known yet. By using human tissue biopsies, a cardiomyocyte-specific knockout mouse model (ADAM10 KO), pharmacological inhibition we here comprehensively characterize...
RNA binding proteins (RBP) play an essential role in the post-transcriptional control of RNAs. Less is known about RBPs liver, particularly hepatocyte-specific function. The RBP, HuR (encoded by Elavl1; embryonic lethal abnormal vision like 1) regulates mRNA splicing and stability. We found that diminished human livers with steatosis and/or non-alcoholic steatohepatitis (NASH) it a network pathways are hepatic-lipid homeostasis maintenance. Hepatocyte-specific deficient mice exhibited severe...