A5088141005- Immune cells in cancer
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Acute Myeloid Leukemia Research
- Inflammasome and immune disorders
- Immune Response and Inflammation
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cell Adhesion Molecules Research
- Immune responses and vaccinations
- Phagocytosis and Immune Regulation
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- COVID-19 Clinical Research Studies
- Complement system in diseases
- Hematopoietic Stem Cell Transplantation
- Blood Coagulation and Thrombosis Mechanisms
- interferon and immune responses
- Autophagy in Disease and Therapy
- Bone and Joint Diseases
- SARS-CoV-2 and COVID-19 Research
- Blood disorders and treatments
- IL-33, ST2, and ILC Pathways
- Systemic Lupus Erythematosus Research
- Multiple Myeloma Research and Treatments
- Neonatal Respiratory Health Research
- Hemoglobinopathies and Related Disorders
Democritus University of Thrace
2012-2025
University Hospital of Alexandroupolis
2008-2025
National Center for Tumor Diseases
2018-2023
TU Dresden
2014-2023
National and Kapodistrian University of Athens
2023
Center for Rheumatology
2023
University Hospital Carl Gustav Carus
2013-2023
Heidelberg University
2018-2021
German Cancer Research Center
2018-2021
Helmholtz-Zentrum Dresden-Rossendorf
2018-2019
Trained innate immunity fosters a sustained favorable response of myeloid cells to secondary challenge, despite their short lifespan in circulation. We thus hypothesized that trained acts via modulation hematopoietic stem and progenitor (HSPCs). Administration β-glucan (prototypical trained-immunity-inducing agonist) mice induced expansion progenitors the lineage, which was associated with elevated signaling by immune mediators, such as IL-1β granulocyte-macrophage colony-stimulating factor...
Emerging data indicate that complement and neutrophils contribute to the maladaptive immune response fuels hyperinflammation thrombotic microangiopathy, thereby increasing coronavirus 2019 (COVID-19) mortality. Here, we investigated how interacts with platelet/neutrophil extracellular traps (NETs)/thrombin axis, using COVID-19 specimens, cell-based inhibition studies, NET/human aortic endothelial cell (HAEC) cocultures. Increased plasma levels of NETs, tissue factor (TF) activity, sC5b-9...
Trained innate immunity, induced via modulation of mature myeloid cells or their bone marrow progenitors, mediates sustained increased responsiveness to secondary challenges. Here, we investigated whether anti-tumor immunity can be enhanced through induction trained immunity. Pre-treatment mice with β-glucan, a fungal-derived prototypical agonist resulted in diminished tumor growth. The effect β-glucan-induced was associated transcriptomic and epigenetic rewiring granulopoiesis neutrophil...
Neutrophil extracellular traps (NETs) are chromatin filaments released by activated polymorphonuclear neutrophils (PMNs) and decorated with granule proteins various properties. Several lines of evidence implicate NETs in thrombosis. The functional significance the vivo relevance during atherothrombosis humans have not been addressed until now.Selective sampling thrombotic material surrounding blood from infarct-related coronary artery (IRA) non-IRA was performed primary percutaneous...
Background Gout is a prevalent inflammatory arthritis affecting 1–2% of adults characterized by activation innate immune cells monosodium urate (MSU) crystals resulting in the secretion interleukin-1β (IL-1β). Since neutrophils play major role gout we sought to determine whether their may involve formation proinflammatory neutrophil extracellular traps (NETs) relation autophagy and IL-1β. Methodology/Principal Findings Synovial fluid from six patients with crisis peripheral blood acute...
Neutrophil activation by inflammatory stimuli and the release of extracellular chromatin structures (neutrophil traps - NETs) have been implicated in disorders. Herein, we demonstrate that NETs released neutrophils treated either with fibrosis-related agents, such as cigarette smoke, magnesium silicate, bleomycin, or generic NET inducers, phorbol 12-myristate 13-acetate, induced lung fibroblasts (LFs) differentiation into myofibroblast (MF) phenotype. Interestingly, aforementioned agents...
<h3>Objectives</h3> Antineutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV) is characterised by neutrophil activation. An elevated prevalence of venous thromboembolic events has been reported in AAV. Because the critical role neutrophils inflammation thrombosis, we asked whether tissue factor (TF) may be implicated thrombotic diathesis <h3>Methods</h3> Neutrophils from four patients and sera 17 with ANCA active disease remission were studied. TF expression was assessed...
Background Sepsis is associated with systemic inflammatory responses and induction of coagulation system. Neutrophil extracellular traps (NETs) constitute an antimicrobial mechanism, recently implicated in thrombosis via platelet entrapment aggregation. Methodology/Principal Findings In this study, we demonstrate for the first time localization thrombogenic tissue factor (TF) NETs released by neutrophils derived from patients gram-negative sepsis normal treated either serum septic or...
The induction of the autophagy machinery, a process for catabolism cytosolic proteins and organelles, constitutes crucial mechanism in innate immunity. However, involvement human neutrophils possible inducers this have not been completely elucidated. In study, was examined treated with various activators detected by formation acidified autophagosomes through monodansylcadaverine staining via LC-3B conversion screened immunoblotting immunofluorescence confocal microscopy. addition, expression...
Aberrant immune responses represent the underlying cause of central nervous system (CNS) autoimmunity, including multiple sclerosis (MS). Recent evidence implicated crosstalk between coagulation and immunity in CNS autoimmunity. Here we identify factor XII (FXII), initiator intrinsic cascade kallikrein-kinin system, as a specific cell modulator. High levels FXII activity are present plasma MS patients during relapse. Deficiency or pharmacologic blockade renders mice less susceptible to...
Abstract Infiltration of neutrophils into colonic mucosa has been associated with the severity ulcerative colitis (UC). We investigated effect disease microenvironment on release neutrophil extracellular traps (NETs) as well involved mechanisms in NETosis and whether certain NET proteins are correlated phenotype. Peripheral blood neutrophils, sera, tissue were collected from treatment-naive mesalazine-treated patients active UC, Crohn’s disease, suffering infectious colitis, or healthy...