A5071387705- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Gut microbiota and health
- Inflammasome and immune disorders
- Diet and metabolism studies
- COVID-19 Clinical Research Studies
- Legionella and Acanthamoeba research
- Animal Virus Infections Studies
- Asthma and respiratory diseases
- Pregnancy and preeclampsia studies
- Nutritional Studies and Diet
- S100 Proteins and Annexins
- Bacterial Infections and Vaccines
- Bacterial biofilms and quorum sensing
- Vaccine Coverage and Hesitancy
- SARS-CoV-2 and COVID-19 Research
- Viral gastroenteritis research and epidemiology
- Immune cells in cancer
- Birth, Development, and Health
- Influenza Virus Research Studies
- Brucella: diagnosis, epidemiology, treatment
- Infant Nutrition and Health
- Gastrointestinal motility and disorders
- Hepatitis Viruses Studies and Epidemiology
- Blood groups and transfusion
- Amoebic Infections and Treatments
Democritus University of Thrace
2015-2024
University of Ioannina
2023
University Hospital of Alexandroupolis
2014-2022
Centers for Disease Control and Prevention
2014
Hellenic Center for Disease Control & Prevention
2013
Aristotle University of Thessaloniki
1994-2000
Emerging data indicate that complement and neutrophils contribute to the maladaptive immune response fuels hyperinflammation thrombotic microangiopathy, thereby increasing coronavirus 2019 (COVID-19) mortality. Here, we investigated how interacts with platelet/neutrophil extracellular traps (NETs)/thrombin axis, using COVID-19 specimens, cell-based inhibition studies, NET/human aortic endothelial cell (HAEC) cocultures. Increased plasma levels of NETs, tissue factor (TF) activity, sC5b-9...
Neutrophil extracellular traps (NETs) are chromatin filaments released by activated polymorphonuclear neutrophils (PMNs) and decorated with granule proteins various properties. Several lines of evidence implicate NETs in thrombosis. The functional significance the vivo relevance during atherothrombosis humans have not been addressed until now.Selective sampling thrombotic material surrounding blood from infarct-related coronary artery (IRA) non-IRA was performed primary percutaneous...
Neutrophil activation by inflammatory stimuli and the release of extracellular chromatin structures (neutrophil traps - NETs) have been implicated in disorders. Herein, we demonstrate that NETs released neutrophils treated either with fibrosis-related agents, such as cigarette smoke, magnesium silicate, bleomycin, or generic NET inducers, phorbol 12-myristate 13-acetate, induced lung fibroblasts (LFs) differentiation into myofibroblast (MF) phenotype. Interestingly, aforementioned agents...
<h3>Objective</h3> Inflammatory attacks of familial Mediterranean fever (FMF) are characterised by circulation and influx high number polymorphonuclear neutrophils (PMN) in the affected sites profound therapeutic effect IL-1β inhibitors. We investigated role neutrophil extracellular traps (NET) pathogenesis FMF, their involvement production. <h3>Methods</h3> Blood samples were obtained from six FMF patients during remissions three attacks. NET formation components studied fluorescence...
Background: While all European countries implement vaccination programs for children, there are gaps in terms of adults. Methods: We studied the 2019 policies adults 42 countries. Results: Vaccination were place However, considerable differences between number vaccinations, target populations and frame implementation (recommended or mandatory vaccinations). In particular following place: influenza (42 countries), tetanus (31), diphtheria (30), pneumococcus (29), hepatitis B (20), pertussis...
Abstract Aiming to define the evolution pattern of 10 acute-phase proteins in early infancy, we measured nephelometrically serum concentrations albumin, prealbumin, retinol-binding protein, transferrin, ceruloplasmin, hemopexin, haptoglobin, alpha 1-acid glycoprotein, 2-macroglobulin, and 1-antitrypsin 395 term preterm infants (gestational ages 26-41 weeks). Measurements were performed within 24 h after birth then at end 1 (n = 171), 3 155), 6 90) months afterwards. Data obtained from 250...
Macrolide antibiotics have been shown to act as immunomodulatory molecules in various immune cells. However, their effect on neutrophils has not extensively investigated. In this study, we investigated the role of macrolide generation neutrophil extracellular traps (NETs). By assessing ex vivo and NET formation, demonstrated that clarithromycin is able induce both vitro vivo. Clarithromycin utilizes autophagy order form NETs, these NETs are decorated with antimicrobial peptide LL-37....
Background To study the levels of procalcitonin (PCT) in patients with meningitis and control group compare them established markers infection—such as C‐reactive protein (CRP), high‐sensitivity CRP, WBC—in cerebrospinal fluid (CSF) assess possible discriminative role PCT differential diagnosis from other noninfectious diseases. Methods We studied CSF samples Intensive Care Unit, Internal Medicine, Neurology, Hematology, Pediatric departments. The total number included was 58. were divided...
Background: Type 2 diabetes mellitus (T2D) is characterized by susceptibility to bacterial infections and impaired wound healing. Neutrophil extracellular traps (NETs) the cathelicidin antimicrobial peptide LL-37 have been implicated both in defense against healing process. Recently, it was shown that macrolide antibiotic clarithromycin induces release of LL-37-bearing NETs. In T2D there has not identified any link between NETs effect neutrophils/NETs unknown yet. Methods: Peripheral blood...
Abstract Emerging data indicate that complement and neutrophils are involved in the maladaptive host immune response fuels hyper-inflammation thrombotic microangiopathy increasing mortality rate coronavirus disease 2019 (COVID-19). Here, we investigated interaction between platelet/neutrophil extracellular traps (NETs)/thrombin axis, using COVID-19 clinical samples, cell-based inhibition studies NETs/human aortic endothelial cell (HAEC) co-cultures. Increased plasma levels of NETs, TF...
Childhood asthma is a chronic inflammatory airway disorder that can drive tissue remodeling. Neutrophils are amongst the most prominent cells contributing to disease manifestations and may exert potent role in progression of inflammation fibrosis. However, their exacerbation still understudied. Here, we investigate association between neutrophil extracellular traps (NETs) lung fibroblasts childhood pathophysiology using serum samples from pediatric patients during exacerbation. Cell-based...