Amelia Willett
A5019173977- RNA modifications and cancer
- Adolescent and Pediatric Healthcare
- Hedgehog Signaling Pathway Studies
- Receptor Mechanisms and Signaling
- Ion channel regulation and function
- Cancer-related Molecular Pathways
- Pharmacological Effects of Natural Compounds
- Ubiquitin and proteasome pathways
- Connective tissue disorders research
- Corneal surgery and disorders
- Cardiomyopathy and Myosin Studies
- Ocular Disorders and Treatments
- Employment and Welfare Studies
- Retinal Development and Disorders
- bioluminescence and chemiluminescence research
- Healthcare innovation and challenges
- Animal Genetics and Reproduction
- Neurobiology and Insect Physiology Research
- Craniofacial Disorders and Treatments
- Corneal Surgery and Treatments
- Pain Mechanisms and Treatments
- Cardiac electrophysiology and arrhythmias
- Congenital heart defects research
Jackson Laboratory
2021-2025
Baylor College of Medicine
2018-2019
Clinical presentation of congenital heart disease is heterogeneous, making identification the disease-causing genes and their genetic pathways mechanisms action challenging. By using in vivo electrocardiography, transthoracic echocardiography microcomputed tomography imaging to screen 3,894 single-gene-null mouse lines for structural functional cardiac abnormalities, here we identify 705 with arrhythmia, myocardial hypertrophy and/or ventricular dilation. Among these genes, 486 have not been...
Abstract Purpose Corneal dysmorphologies (CDs) are typically classified as either regressive degenerative corneal dystrophies (CDtrs) or defective growth and differentiation-driven dysplasias (CDyps). Both eye disorders have multifactorial etiologies. While previous work has elucidated many aspects of CDs, such presenting symptoms, epidemiology, pathophysiology, the genetic mechanisms remain incompletely understood. The purpose this study was to analyze phenotype data from 8,707 knockout...
Abstract Despite advances in next generation sequencing technologies, determining the genetic basis of ocular disease remains a major challenge due to limited access and prohibitive cost human forward genetics. Thus, less than 4,000 genes currently have available phenotype information for any organ system. Here we report ophthalmic findings from International Mouse Phenotyping Consortium, large-scale functional screen with goal generating phenotyping null mutant every mouse gene. Of 4364...
Identifying the genetic determinants of pain is a scientific imperative given magnitude global health burden that causes. Here, we report screen for nociception, performed under auspices International Mouse Phenotyping Consortium. A biased set 110 single-gene knockout mouse strains was screened 1 or more nociception and hypersensitivity assays, including chemical (formalin) mechanical thermal (von Frey filaments Hargreaves tests, respectively), with without an inflammatory agent (complete...
To explore whether people from Black, Asian and minority ethnic (BAME) communities experience equality of access outcome in individual placement support (IPS) employment services. Cross-sectional data were analysed all with severe mental health problems who accessed two mature high-fidelity IPS services London 2019 (n = 779 people).