A5018596726- Osteoarthritis Treatment and Mechanisms
- Inflammatory mediators and NSAID effects
- Metabolomics and Mass Spectrometry Studies
- Rheumatoid Arthritis Research and Therapies
- Advanced Proteomics Techniques and Applications
- Mathematics, Computing, and Information Processing
- Synthesis and biological activity
- Spacecraft Design and Technology
- scientometrics and bibliometrics research
- Computational Drug Discovery Methods
- Scientific Computing and Data Management
- Cancer-related Molecular Pathways
- Biosimilars and Bioanalytical Methods
- Cell Image Analysis Techniques
- Mass Spectrometry Techniques and Applications
- Bone health and treatments
- Bone Metabolism and Diseases
- Nutrition, Genetics, and Disease
- Animal Genetics and Reproduction
- Retinal Development and Disorders
- Genetic Associations and Epidemiology
- Bone health and osteoporosis research
- Machine Learning in Bioinformatics
- Genetics, Bioinformatics, and Biomedical Research
- Ubiquitin and proteasome pathways
European Bioinformatics Institute
2023-2025
Mary Lyon Centre at MRC Harwell
2018-2020
Medical Research Council
2018-2019
University of Nottingham
2011-2015
Investigations into novel biomarkers using omics techniques generate large amounts of data. Due to their size and numbers attributes, these data are suitable for analysis with machine learning methods. A key component typical pipelines is feature selection, which used reduce the raw high-dimensional a tractable number features. Feature selection needs balance objective as few features possible, while maintaining high predictive power. This crucial when goal identification highly accurate but...
Abstract Despite advances in next generation sequencing technologies, determining the genetic basis of ocular disease remains a major challenge due to limited access and prohibitive cost human forward genetics. Thus, less than 4,000 genes currently have available phenotype information for any organ system. Here we report ophthalmic findings from International Mouse Phenotyping Consortium, large-scale functional screen with goal generating phenotyping null mutant every mouse gene. Of 4364...
The genetic landscape of diseases associated with changes in bone mineral density (BMD), such as osteoporosis, is only partially understood. Here, we explored data from 3,823 mutant mouse strains for BMD, a measure that frequently altered range pathologies, including osteoporosis. A total 200 genes were found to significantly affect BMD. This pool BMD comprised 141 previously unknown functions biology and was complementary pools derived recent human studies. Nineteen the also caused skeletal...
EMBL-EBI is the home of world's most comprehensive range freely available molecular databases and resources. Our resources help researchers share analyse data perform complex queries in many different ways. Join us for a tour core at EMBL-EBI. During this webinar, we will introduce types available, how you can search various ways getting assistance. We also discuss role making open accessible, include your workflows. provide information on further online training to learn more about specific...
Abstract Background Osteoarthritis (OA) is an inflammatory disease of synovial joints involving the loss and degeneration articular cartilage. The gold standard for evaluating cartilage in OA measurement joint space width on radiographs. However, most cases diagnosis made well after onset disease, when symptoms are established. Identification early biomarkers can facilitate earlier diagnosis, improve monitoring predict responses to therapeutic interventions. Methods This study describes...
EMBL-EBI provides a broad range of training in data-driven life sciences. To improve awareness and access to course listings make digital learning materials findable simple use, the Training website, www.ebi.ac.uk/training , was redesigned restructured. provide framework for redesign FAIR (findable, accessible, interoperable, reusable) principles were applied both live courses presentation on-demand content. Each guided decisions on choice technology used develop including details provided...