A5050463649- RNA and protein synthesis mechanisms
- Medical Imaging Techniques and Applications
- Genomics and Chromatin Dynamics
- Radiomics and Machine Learning in Medical Imaging
- Thyroid Cancer Diagnosis and Treatment
- HIV Research and Treatment
- Cell death mechanisms and regulation
- Chromosomal and Genetic Variations
- Bioinformatics and Genomic Networks
- Genomics and Phylogenetic Studies
- Hematological disorders and diagnostics
- Visual Attention and Saliency Detection
- RNA Interference and Gene Delivery
- Advanced Image and Video Retrieval Techniques
- Bone health and treatments
- Public Administration and Political Analysis
- Gene expression and cancer classification
- RNA modifications and cancer
- Neuroendocrine Tumor Research Advances
- Cancer Treatment and Pharmacology
- Genomic variations and chromosomal abnormalities
- Multiple Myeloma Research and Treatments
- Water Systems and Optimization
- Cancer-related molecular mechanisms research
- Cytokine Signaling Pathways and Interactions
University of Pennsylvania
2013-2025
University of Freiburg
2025
Hospital of the University of Pennsylvania
2017-2024
University of Michigan
2018-2022
Michigan United
2020
Philadelphia University
2016-2019
Heinrich Heine University Düsseldorf
1992-2018
Düsseldorf University Hospital
2013-2018
Fraunhofer Institute for Intelligent Analysis and Information Systems
2015-2018
University of Bonn
2014-2015
In this paper, a new way to think about, and construct, pairwise as well multiple alignments of DNA protein sequences is proposed. Rather than forcing either align single residues or introduce gaps by defining an alignment path running right from the source up sink in associated dot-matrix diagram, we propose consider consistent equivalence relations defined on set all positions occurring under consideration. We also constructing whole segments exhibiting highly significant overall...
IL-10 is a unique cytokine because it anti-inflammatory and immunosuppressive. regulated at the level of transcription, but critical motifs relevant transcription factors controlling this gene have remained elusive to date. We now report that sequence -120 bp in human promoter binds Stat3 no other Stat proteins. Mutation motif abrogates LPS-induced trans-activation. Overexpression dominant negative suppresses activity, while wild-type leads an enhancement activity. Our results show Stat3, by...
In this paper, we show that the seminal, biologically-inspired saliency model by Itti et al. [21] is still competitive with current state-of-the-art methods for salient object segmentation if some important adaptions are made. We which changes necessary to achieve high performance, special emphasis on scale-space: introduce a twin pyramid computing Difference-of-Gaussians, enables flexible center-surround ratio. The resulting system, called VOCUS2, elegant and coherent in structure, fast,...
The persistent infection of human glial cells with HIV-1 is characterized by prominent expression the Nef protein. In order to evaluate possible role in development HIV-1-associated neurological disorders, we compared known neuroactive proteins. We found that HIV shares sequence and structural features scorpion peptides interact K+ channels. Sequence similarity encompasses two distinct regions peptides. Based on crystallography data, both cooperate forming a common domain stabilized ion...
Background Diabetic nephropathy (DN) is a complex and chronic metabolic disease that evolves into progressive fibrosing renal disorder. Effective transcriptomic profiling of slowly evolving processes such as DN can be problematic. The changes occur are often subtle escape detection by conventional oligonucleotide DNA array analyses. Methodology/Principal Findings We examined microdissected human tissue with or without using Affymetrix microarrays (HG-U133A) standard Robust Multi-array...
To determine the role of BRAF V600E mutation and MAPK signaling as well effects MEK directed therapy in gastroenteropancreatic neuroendocrine neoplasia (GEP‐NEN), with a focus on highly aggressive carcinoma (GEP‐NEC). Using Sanger sequencing exon 15 we determined frequency mutations 71 primary GEP‐NENs. phosphorylation was examined by immunohistochemistry corresponding tissue samples. evaluate biological relevance GEP‐NECs, pharmacological inhibition were analyzed NEC cell lines both vitro...
Medullary thyroid carcinoma (MTC) accounts for ∼5% of all malignancies. To date, surgery is the first-line therapy with curative intention. However, advanced MTC, conventional chemotherapeutic agents do not provide convincing results. Therefore, identification biomarkers that can be antagonised by small-molecule therapeutics may lead to novel encouraging treatment options. Seventy-nine patients surgically resected and histologically confirmed MTC were included in this study. Tissue...
Abstract— Novel synthetic polyene polyketones and new capsorubin isomers were examined for their ability to quench singlet molecular oxygen ( 1 O 2 ) generated by the thermodissociation of endoperoxide 3,3'‐(l,4‐naphthylene) dipropionate (NDPO ). C 28 ‐polyene‐tetrone exhibits highest physical quenching rate constant with (k q = 16 × 10 9 M ‐1 s For comparison, most efficient biological carotenoid, lycopene 3 is k that β‐carotene 5 . The presence two oxalyl chromophores at ends chain seems...
Background: Follicular thyroid carcinoma's (FTC) often benign course is partially due to adjuvant radioactive iodine (RAI) treatment. However, once the tumour has spread and fails retain RAI, therapeutic options are limited outcome poor. In this subset of patients, identification novel druggable biomarkers appears invaluable. Here, we investigated stage dependent expression functional role C-X-C chemokine receptors type 4 7 (CXCR4/7) in FTC. Methods: CXCR4/7 was examined 44 FTC corresponding...
Medullary thyroid carcinoma (MTC) is a rare and challenging endocrine malignancy. Once spread, the therapeutic options are limited outcome poor. For these patients, identification of new druggable biological markers great importance. Here, we investigated prognostic role C-X-C chemokine receptors type 4 7 (CXCR4/7) in MTC. Eighty-six MTC corresponding non-neoplastic specimens were immunohistochemically stained for CXCR4/7 using tissue microarray technology expression levels correlated with...
Abstract Deletions of chromosome arm 10q are found in most glioblastomas and subsets lower grade gliomas. Mutations the PTEN gene at 10q23.3 restricted to less than half 10q‐deleted gliomas, suggesting additional glioma‐associated tumor suppressors on 10q. We investigated 64 astrocytic gliomas different malignancy grades for aberrant expression 16 micro RNAs ( miRNAs ) Thereby, we identified four miR‐107 , miR‐146b‐5p miR‐346 miR‐1287‐5p whose was frequently down‐regulated anaplastic...
The genetic landscape of diseases associated with changes in bone mineral density (BMD), such as osteoporosis, is only partially understood. Here, we explored data from 3,823 mutant mouse strains for BMD, a measure that frequently altered range pathologies, including osteoporosis. A total 200 genes were found to significantly affect BMD. This pool BMD comprised 141 previously unknown functions biology and was complementary pools derived recent human studies. Nineteen the also caused skeletal...
Abstract The FreezeO Organoid Biobank at the University Medical Center Freiburg represents an innovative resource and integral extension of Molecular Tumor Board (MTB) that enables patient-specific drug testing for precision oncology. focus this biobank is to isolate culture patient-derived organoids (PDOs) from fresh tumor biopsies, particularly metastatic sites, address unmet need therapy recommendations in advanced cancer. Our workflow begins when MTB decides obtain new biopsies whole...
Intracranial atherosclerosis is a leading cause of stroke and cognitive dysfunction. Calcification intracranial atherosclerotic plaques commonly observed on noncontrast CT, yet structural imaging alone cannot visualize active microcalcifications characteristic progressive atheroma. 18 F-NaF an emerging PET radiotracer vascular microcalcification that may enable the detection such pathophysiology. In this report, we present molecular left vertebral artery incidentally found PET/CT 64-year-old...
We present a novel method based on saliency and segmentation to generate generic object candidates from RGB-D data. Our uses as cue roughly estimate the location extent of objects in scene. Salient regions are used glue together segments obtained over-segmenting scene by either color or depth algorithms, combination both. suggest late-fusion approach that first extracts independently before fusing them exploit data is complementary. Furthermore, we investigate several mechanisms for ranking...
Based on their overexpression and important roles in progression therapy-resistance malignant diseases, the inhibitor of apoptosis protein family (IAP) members, survivin X‑linked (XIAP), represent attractive candidates for targeted therapy. The present study investigated prognostic biological relevance XIAP esophageal squamous‑cell carcinoma (ESCC) adenocarcinoma (EAC). Survivin expression was analyzed by immunohistochemistry using tissue microarrays containing 120 ESCC 90 EAC samples as...