A5101896668- RNA modifications and cancer
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Extracellular vesicles in disease
- Seed Germination and Physiology
- Ferroptosis and cancer prognosis
- Legume Nitrogen Fixing Symbiosis
- Cancer, Hypoxia, and Metabolism
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Magnetic and Electromagnetic Effects
- Ubiquitin and proteasome pathways
- Plant-Microbe Interactions and Immunity
- Plant tissue culture and regeneration
- Advanced Fiber Laser Technologies
- Nonmelanoma Skin Cancer Studies
- Pancreatic function and diabetes
- Pharmacological Effects of Natural Compounds
- Pancreatic and Hepatic Oncology Research
- Plant Molecular Biology Research
- Plant Pathogens and Fungal Diseases
- Agronomic Practices and Intercropping Systems
- Cancer-related gene regulation
- Hedgehog Signaling Pathway Studies
- Digital Holography and Microscopy
Shanghai Ninth People's Hospital
2023-2025
Shanghai Jiao Tong University
2023-2025
Shanghai Institute of Hematology
2023-2025
Guangxi University
2021-2024
Guilin University of Electronic Technology
2024
Harbin Medical University
2021-2024
Second Affiliated Hospital of Harbin Medical University
2021-2024
Toronto Centre for Phenogenomics
2021-2022
Lunenfeld-Tanenbaum Research Institute
2021
Sichuan Normal University
2021
Summary Seeds use environmental cues to sense the seasons and their surroundings initiate life cycle of plant. The dormancy cycling underlying this process is extensively described, but molecular mechanism largely unknown. To address we selected a range representative genes from published array experiments in laboratory, investigated expression patterns seeds A rabidopsis ecotypes with contrasting cycles over an annual field. We show how mechanisms identified laboratory are coordinated...
Seed yield and dormancy status are key components of species fitness that influenced by the maternal environment, in particular temperature. Responses to environmental conditions can differ between ecotypes same species. Therefore, investigate effect environment on seed production, this study compared two contrasting Arabidopsis thaliana ecotypes, Cape Verdi Isle (Cvi) Burren (Bur). Cvi is adapted a hot dry climate Bur cool damp climate, they exhibit winter summer annual phenotypes,...
Transposable elements constitute an important part of the genome and are essential in adaptive mechanisms. Transposition events associated with phenotypic changes occur naturally or induced insertional mutant populations. Transposon mutagenesis results multiple random insertions recovery most/all is critical for forward genetics study. Using next-generation sequencing data appropriate bioinformatics tool, it plausible to accurately identify transposon insertion sites, which could provide...
Legume research and cultivar development are important for sustainable food production, especially of high-protein seed. Thanks to the deep-sequencing technologies, crop species have been taken front line, even without completion their genome sequences. Black-eyed pea (Vigna unguiculata) is a legume widely grown in semi-arid regions, which has high potential provide stable seed protein production broad range environments, including drought conditions. The black-eyed reference genotype used...
Abstract Seed characteristics are key components of plant fitness that influenced by temperature in their maternal environment, and will change with global warming. To study the effect such changes, Arabidopsis thaliana plants were grown to produce seeds along a uniquely designed polyethylene tunnel having thermal gradient reflecting local warming predictions. Plants therefore experienced same variations light conditions but different mean temperatures. A range seed‐related estimates...
Abstract Background Microphthalmia, anophthalmia, and coloboma (MAC) spectrum disease encompasses a group of eye malformations which play role in childhood visual impairment. Although the predominant cause is known to be heritable nature, with 80% cases displaying loss-of-function mutations ocular developmental genes OTX2 or SOX2, genetic abnormalities underlying remaining MAC are incompletely understood. This study intended identify novel pathways required for early development....
Abstract Seeds have evolved to be highly efficient environmental sensors that respond not only their prevailing environment, but also history, regulate dormancy and the initiation of germination. In present work we investigate combined impact a number signals (temperature, nitrate, light) during seed development on mother plant, post-shedding imbibition prolonged exposure in both dry imbibed states, simulating time soil bank. The differing response these environments was observed contrasting...
Purpose: To evaluate the prognosis of eyelid sebaceous carcinoma (SeC) in patients with disease stage worse than IIA. Methods: This retrospective, single-center study included 78 SeC patients. For II patients, 1:3 propensity score matching (PSM) was applied between those undergoing orbital exenteration and receiving eye-sparing treatments. Risk factors group were analyzed using Cox regression, Kaplan–Meier survival analysis assessed metastasis-free (MFS), recurrence-free (RFS),...
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with a notably poor prognosis.A large number of patients PDAC develop metastases before they are diagnosed metastatic pancreatic cancer (mPDAC).For mPDAC, FOLFIRINOX or gemcitabine plus nab-paclitaxel the current first-line treatments.It important to note, however, that many will fail chemotherapy because drug resistance.Heterogeneous tumors and complex tumor microenvironments key factors.As result, clinical researchers...
The ribophorin family (RPN) is an essential regulatory subunit of the proteasome. By influencing ubiquitin-proteasome system activity, ribophorins (RPNs) are responsible for almost all physiology and pathology processes mammalian cells. Nevertheless, little known about role RPNs in HCC. In this work, we first evaluated transcriptional levels prognostic diagnostic value based on public database. Firstly, found were surprisingly consistently upregulated HCC tissues. Moreover, RPNs' expression...
We propose a robust and accurate compensation method for phase aberrations based on the iterative outlier detection refinement (ODR) rule. This does not require additional steps to select known flat region manually or by image segmentation. Based proposed method, aberration in regions of specimen can be detected refined iteratively. Then, least squares fitting carried out estimate coefficients Zernike polynomials obtain finally. Computer simulations real experiments validate feasibility...
To elucidate the biological mechanisms driving growth of various pumpkin varieties to different sizes under identical management conditions while in same field, soil microbial community structures rhizospheres giant-pumpkin (GP) and small-pumpkin (SP) were analyzed. The results revealed that a significantly higher abundance bacterial communities could be detected giant varieties, such as Gemmatimonadota, norank__f__norank__o_Gaiellales, norank__f__Gemmatimonadaceae, Bryobacter, Sphingomonas,...
Identifying the genetic determinants of pain is a scientific imperative given magnitude global health burden that causes. Here, we report screen for nociception, performed under auspices International Mouse Phenotyping Consortium. A biased set 110 single-gene knockout mouse strains was screened 1 or more nociception and hypersensitivity assays, including chemical (formalin) mechanical thermal (von Frey filaments Hargreaves tests, respectively), with without an inflammatory agent (complete...