A5026068211- Gene expression and cancer classification
- Bioinformatics and Genomic Networks
- Machine Learning in Bioinformatics
- Biomedical Text Mining and Ontologies
- SARS-CoV-2 and COVID-19 Research
- vaccines and immunoinformatics approaches
- Genomics and Phylogenetic Studies
- Rough Sets and Fuzzy Logic
- RNA and protein synthesis mechanisms
- COVID-19 diagnosis using AI
- Machine Learning in Healthcare
- Phytoestrogen effects and research
- Protein Structure and Dynamics
- Scientific Computing and Data Management
- Data Mining Algorithms and Applications
- Image and Signal Denoising Methods
- Cancer Genomics and Diagnostics
- Artificial Intelligence in Healthcare
- Intellectual Property Rights and Media
- Human-Automation Interaction and Safety
- Digital Rights Management and Security
- Advanced Image Fusion Techniques
- RNA Research and Splicing
- Research Data Management Practices
- Diet, Metabolism, and Disease
Silesian University of Technology
2016-2025
Krakow University of Economics
2015-2022
Cardiff Metropolitan University
2021
Cardiff University
2018-2021
Institute of Informatics of the Slovak Academy of Sciences
2005-2012
The Maria Sklodowska-Curie National Research Institute of Oncology
2009
Abstract Low complexity regions (LCRs) in protein sequences are characterized by a less diverse amino acid composition compared to typically observed sequence diversity. Recent studies have shown that LCRs may co-occur with intrinsically disordered regions, highly conserved many organisms, and often play important roles functions diseases. In previous decades, several methods been developed identify or bias, but most of them as stand-alone applications currently there is no web-based tool...
The rapid development of machine learning (ML) techniques has opened up the data-dense field microbiome research for novel therapeutic, diagnostic, and prognostic applications targeting a wide range disorders, which could substantially improve healthcare practices in era precision medicine. However, several challenges must be addressed to exploit benefits ML this fully. In particular, there is need establish “gold standard” protocols conducting analysis experiments interactions between...
The need to find new EGFR inhibitors for use in combination with radiotherapy the treatment of solid tumors has drawn our attention compounds derived from genistein, a natural isoflavonoid. antiproliferative potential synthetic genistein derivatives used alone or ionizing radiation was evaluated cancer cell lines using clonogenic assay. phosphorylation assessed western blotting. Genistein inhibited growth HCT 116 cells additively synergistically when radiation, and decreased activation. Our...
Low complexity regions are fragments of protein sequences composed only a few types amino acids. These frequently occur in proteins and can play an important role their functions. However, scientists mainly focused on characterized by high diversity acid composition. Similarity between reflect functional similarity them. In this article, we discuss strengths weaknesses the analysis low using BLAST, HHblits CD-HIT. methods considered to be gold standard were designed for comparison regions....
Abstract The development of antimetastatic drugs is an urgent healthcare priority for patients with cancer, because metastasis thought to account around 90% cancer deaths. Current treatment options are limited and often associated poor long-term survival systemic toxicities. Bcl3, a facilitator protein the NF-κB family, prognosis in range tumor types. Bcl3 has been directly implicated cells, yet well tolerated when constitutively deleted murine models, making it promising therapeutic target....
Electrostatic interactions play important roles in the functional mechanisms exploited by intrinsically disordered proteins (IDPs). The atomic resolution description of long-range and local structural propensities that can both be crucial for function highly charged IDPs presents significant experimental challenges. Here, we investigate conformational behavior δ subunit RNA polymerase from Bacillus subtilis whose unfolded domain is charged, with 7 positively amino acids followed 51 acidic...
Abstract Background The rapid spread of the COVID-19 demands immediate response from scientific communities. Appropriate countermeasures mean thoughtful and educated choice viral targets (epitopes). There are several articles that discuss such choices in SARS-CoV-2 proteome, other focus on phylogenetic traits history Coronaviridae genome/proteome. However none consider protein low complexity regions (LCRs). Recently we created first methods able to compare fragments. Results We show five...
Genome-wide expression profiles obtained with the use of DNA microarray technology provide abundance experimental data on biological and molecular processes. Such amount need to be further analyzed interpreted in order obtain conclusions basis results. The analysis requires a lot experience is usually time-consuming process. Thus, frequently various annotation databases are used improve whole process analysis. Here, we present RuleGO—the web-based application that allows user describe gene...
Quality improvement of rule-based gene group descriptions using information about GO terms importance occurring in premises determined rules In this paper we present a method for evaluating the which compose multi-attribute rules. The are generated purpose biological interpretation groups. Each rule is combination and, based on relationships among them, one can obtain functional description We allows influence given term quality and whole set For each term, compute how big its therefore...
<ns4:p>Today, academic researchers benefit from the changes driven by digital technologies and enormous growth of knowledge data, on globalisation, enlargement scientific community, linkage between different communities society. To fully this development, however, information needs to be shared openly transparently. Digitalisation plays a major role here because it permeates all areas business, science society is one key drivers for innovation international cooperation. address resulting...
In the DECODE project, data were collected from 3,114 surveys filled by symptomatic patients RT-qPCR tested for SARS-CoV-2 in a single university centre March-September 2020. The population demonstrated balanced sex and age with 759 SARS-CoV-2( +) patients. most discriminative symptoms at early infection stage loss of taste/smell (OR = 3.33, p < 0.0001), body temperature above 38℃ 1.67, muscle aches 1.30, 0.0242), headache 1.27, 0.0405), cough 1.26, 0.0477). Dyspnea was more often reported...
High-resolution remote sensing technology for Earth Observation (EO) has radically changed how we monitor the state of our planet around clock. An effective interpretation resulting complex large-scale time series adopts best machine learning techniques from signal processing, computer vision, pattern recognition, and artificial intelligence. The First Workshop on Complex Data Challenges in was open to both method development advanced applications a wide range related topics, including image...