A5100443687- Fibroblast Growth Factor Research
- Connective tissue disorders research
- Extracellular vesicles in disease
- Mesenchymal stem cell research
- Osteoarthritis Treatment and Mechanisms
- Bone Metabolism and Diseases
- Genetic Mapping and Diversity in Plants and Animals
- Bone health and osteoporosis research
- Bone health and treatments
- MicroRNA in disease regulation
- Immune Cell Function and Interaction
- Inflammasome and immune disorders
- Epigenetics and DNA Methylation
- Spine and Intervertebral Disc Pathology
- Cancer-related gene regulation
- Parathyroid Disorders and Treatments
- Wnt/β-catenin signaling in development and cancer
- Neonatal Respiratory Health Research
- Parasites and Host Interactions
- Immune cells in cancer
- Sarcoma Diagnosis and Treatment
- TGF-β signaling in diseases
- Pancreatitis Pathology and Treatment
- T-cell and B-cell Immunology
- Craniofacial Disorders and Treatments
Army Medical University
2016-2025
Sichuan University
2012-2025
Daping Hospital
2016-2025
People 's Hospital of Jilin Province
2025
Tianjin Medical University General Hospital
2020-2025
General Hospital of Guangzhou Military Command
2012-2025
Sichuan Center for Disease Control and Prevention
2025
Shanghai University of Traditional Chinese Medicine
2025
Hangzhou Normal University
2023-2024
Tsinghua University
2024
Endochondral ossification begins from the condensation and differentiation of mesenchymal cells into cartilage. The cartilage then goes through a program cell proliferation, hypertrophic differentiation, calcification, apoptosis, eventually is replaced by bone. Unlike most cartilage, articular arrested before terminal differentiation. In this study, we showed that TGF-β/Smad3 signals inhibit chondrocyte are essential for maintaining Mutant mice homozygous targeted disruption Smad3 exon 8...
<h3>Importance</h3> The aging of the population is associated with an increasing burden fractures worldwide. However, epidemiological features in mainland China are not well known. <h3>Objective</h3> To assess prevalence and factors osteoporosis, clinical fractures, vertebral adult 40 years or older China. <h3>Design, Setting. Participants</h3> This cross-sectional study, Osteoporosis Prevalence Study, was conducted from December 2017 to August 2018. A random sample individuals aged 20 who...
Acquired drug resistance is a major obstacle to chemotherapy of cancers. In this study, we aim investigate the role exosomes in drug-resistance transfer between breast cancer cells and detect probable mechanism. A docetaxel-resistant variant MCF-7 cell line (MCF-7/DOC) was established then compared with drug-sensitive (MCF-7/S). Exosomes were expelled from supernatant using ultracentrifugation. Drug assessed by apoptosis assay MTT examination. Expressions P-glycoprotein (P-gp) analyzed flow...
Exosomes participate in many physiological and pathological processes by regulating cell-cell communication, which are involved numerous diseases, including osteoarthritis (OA). detectable the human articular cavity were observed to change with OA progression. Several joint cells, chondrocytes, synovial fibroblasts, osteoblasts, tenocytes, can produce secrete exosomes that influence biological effects of targeted cells. In addition, from stem cells protect damage promoting cartilage repair,...
Abstract Sclerostin negatively regulates bone formation by antagonizing Wnt signalling. An antibody targeting sclerostin for the treatment of postmenopausal osteoporosis was approved U.S. Food and Drug Administration, with a boxed warning cardiovascular risk. Here we demonstrate that participates in protecting system inhibiting via different loops. Loop3 deficiency genetic truncation could maintain sclerostin’s protective effect on while attenuating its inhibitory formation. We identify an...
A comprehensive understanding of the cellular heterogeneity and molecular mechanisms underlying development, homeostasis, disease human intervertebral disks (IVDs) remains challenging. Here, transcriptomic landscape 108 IVD cells was mapped using single-cell RNA sequencing three main compartments from young adult healthy IVDs, including nucleus pulposus (NP), annulus fibrosus, cartilage endplate (CEP). The chondrocyte subclusters were classified based on their potential regulatory,...
Cancer-associated mesenchymal stem cells (MSCs) play a pivotal role in modulating tumor progression. However, the interactions between liver cancer-associated MSCs (LC-MSCs) and hepatocellular carcinoma (HCC) remain unreported. Here, we identified presence of HCC tissues. We also showed that LC-MSCs significantly enhanced growth vivo promoted sphere formation vitro. metastasis an orthotopic transplantation model. Complementary DNA (cDNA) microarray analysis S100A4 expression was higher...
Abstract Synovitis, a common clinical symptom for osteoarthritis (OA) patients, is highly related to OA pathological progression and pain manifestation. The activated synovial macrophages have been demonstrated play an important role in synovitis, but the mechanisms about macrophage activation are still not clear. In this study, we found that exosome-like vesicles from osteoarthritic chondrocytes could be new biological factor stimulate inflammasome increase mature IL-1β production...
Significance Most if not all types of insults to the brain, including trauma, stroke, tumor growth, and neurodegeneration, for example, are believed elicit a complex response involving several cell types. Central this is activation astrocytes. Although many proinflammatory molecules activate astrocytes, few factors known suppress their activation. Here we show that disrupting one particular signal specifically in adult astrocytes normal or injured neocortex leads an increase astrocyte...
The exosomal miRNAs have been emerged as biomarkers and therapeutic targets for various diseases, however, the function of in stroke remains largely unknown. blood samples from acute ischemic (AIS) patients normal controls were collected. exosomes isolated samples, which confirmed by electron microscopy western blot with specific biomarker CD9, CD63 Tsg101. RT-qPCR analysis showed that miR-134 was significantly increased AIS within 24 h after onset compared control group. Highly expressed...
Objective Fibroblast growth factor (FGF) signaling is involved in articular cartilage homeostasis. This study was undertaken to investigate the role and mechanisms of FGF receptor 3 (FGFR‐3) pathogenesis osteoarthritis (OA) caused by surgery aging mice. Methods FGFR‐3 conditionally deleted or activated chondrocytes adult mice subjected surgical destabilization medial meniscus (DMM). A mouse model human achondroplasia also used assess age‐associated spontaneous OA. Knee joint histologically...
Synovitis is implicated in the pathology of osteoarthritis (OA) and significantly contributes to development OA. As a noninvasive physical therapy, low-intensity pulsed ultrasound (LIPUS) has been reported possess anti-inflammatory effect recent years. However, role LIPUS on synovitis OA underlying mechanisms are little known. The present study showed that ameliorated synovial inflammation destabilization medial meniscus (DMM) mouse model air pouch model, alleviated pain gait patterns DMM...
Inducing autophagy of macrophages to improve abnormal lipid metabolism is an important way treat atherosclerosis (AS). Yet, the current application mammalian target rapamycin (mTOR)-dependent inducers limited by side effects and lack targeting low biological availability. Herein, a kind nitric oxide (NO)-driven carrier-free nanomotor based on reaction between trehalose (Tr, one mTOR-independent inducers), L-arginine (Arg), phosphatidylserine (PS) reported. The developed nanomotors use NO as...
The pathophysiological mechanisms of diabetic retinopathy (DR), a blinding disease, are intricate. DR was thought to be microvascular disease previously. However, growing studies have indicated that the retinal microglia-induced inflammation precedes microangiopathy. binary concept microglial M1/M2 polarization paradigms during inflammatory activation has been debated. In this study, we confirmed microglia had most significant changes in early using single-cell RNA sequencing. A total five...