A5040126866- Cancer Cells and Metastasis
- Mesenchymal stem cell research
- Tissue Engineering and Regenerative Medicine
- Autophagy in Disease and Therapy
- Cancer Research and Treatments
- Nanoplatforms for cancer theranostics
- Liver physiology and pathology
- Mitochondrial Function and Pathology
- Hydrogen's biological and therapeutic effects
- Gastrointestinal motility and disorders
- Antimicrobial Peptides and Activities
- Digestive system and related health
- Effects of Radiation Exposure
- Immune Response and Inflammation
- Cancer Diagnosis and Treatment
- Berberine and alkaloids research
- Biochemical Acid Research Studies
- Genetics and Neurodevelopmental Disorders
- Inflammatory Bowel Disease
- Pancreatic function and diabetes
- Microtubule and mitosis dynamics
- Radiology practices and education
- Medical Research and Treatments
- Nanoparticle-Based Drug Delivery
- RNA Research and Splicing
Sichuan Cancer Hospital
2022-2025
University of Electronic Science and Technology of China
2022-2025
Chengdu University of Traditional Chinese Medicine
2024
Army Medical University
2011-2021
The pathological mechanisms of radiation ulcer remain unsolved and there is currently no effective medicine. Here, we demonstrate that persistent DNA damage foci cell senescence are involved in development. Further more, identify cordycepin, a natural nucleoside analogue, as potent drug to block (skin, intestine, tongue) rats/mice by preventing through the increase NRF2 nuclear expression (the assay used mainly on skin). Finally, cordycepin also revealed activate AMPK binding with α1 γ1...
We hypothesized that basic helix–loop–helix (bHLH) MIST1 (BHLHA15) is a “scaling factor” universally establishes secretory morphology in cells perform regulated secretion. Here, we show targeted deletion of caused dismantling the apparatus diverse exocrine cells. Parietal (PCs), whose function to pump acid into stomach, normally lack and do not Forced expression PCs them expand their apical cytoplasm, rearrange mitochondrial/lysosome trafficking, generate large granules. Mist1 induced cohort...
Abstract Intestinal stem cells (ISCs) and Paneth (PCs) reside at the bottom of crypts Lieberkühn in small intestine. Recent studies have shown that transcription factor Mist1, also named BHLHA15, plays an important role maturation PCs. Since there is intimate interaction between PCs ISCs, we speculated loss Mist1 could impact these two neighboring cell types. Here, report mice lacking had fewer but larger with shrunken secretory granules, accompanied by increase goblet tuft cells....
Introduction Ulcerative colitis (UC) is a global gastrointestinal disease, which mainly caused by both dysfunctional epithelial barrier and inflammation response. Iron critical fundamental element for the maintenance of homeostasis mediation in many tissues. However, role mechanism iron phase enteritis subsequent repairing intestinal stem cells has not been elucidated. In this study, we aimed to explore whether how depletion would affect occurrence outcome experimental colitis. Methods was...
Abstract The endoplasmic reticulum (ER) stress signaling or unfolded protein response (UPR) is a common feature of many human diseases, including cancer. Excessive activation ER directly induces cell death, holding new promising strategy for the therapeutic intervention Current ER‐stress‐inducing agents mainly target UPR components proteasomes, which exert limited treatment efficacy and undesired side effects due to unselective poor tumor‐specific distribution. In this study, unique...
A near-infrared mitochondrial dye serves as novel oxidative phosphorylation inhibitor for acute myeloid leukemia–targeted imaging.
The increasing incidence of multidrug-resistant Acinetobacter baumannii (MDRAb) infections worldwide has necessitated the development novel antibiotics. Human defensin 5 (HD5) is an endogenous peptide with a complex architecture and antibacterial activity against MDRAb In present study, we attempted to simplify structure HD5 by removing disulfide bonds. We found that Cys2-4 bond was most indispensable for inactivate MDRAb, although derivative significantly attenuated. then replaced...
There is an urgent but unmet need for mitigating radiation-induced intestinal toxicity while radio sensitising tumours abdominal radiotherapy. We aimed to investigate the effects of metformin on and radiosensitivity colorectal tumours.Acute chronic histological injuries intestine from mice were used assess radioprotection IEC-6 cell line was mechanisms in vitro. The fractionated radiation model HCT116 HT29 tumour grafts determine cancer.Metformin alleviated acute by optimising mitophagy...
Vascular endothelial cells are very sensitive to ionizing radiation, and it is important develop effective prevent agents measures in radiation exposure protection. In the present study, protective effects of atorvastatin on irradiated human umbilical vein (HUVEC) possible mechanisms were explored. Cultured HUVEC treated by at a final concentration 10 μ mol/ml for minutes, then dose 2 Gy or 25 Gy. Twenty-four hours after irradiation, apoptosis was monitored flow cytometry, expression...
Abstract The characterization of cancer stem‐like cells (CSCs) has profound implications for elucidating biology and developing treatment strategies. Although surface markers are already used to identify CSCs, the expression these is controversially linked phenotypes in different types tumors does not represent all functionally relevant CSCs. Very recently, hyperactive HIF‐1α/glycolysis metabolic pathway recognized as a master regulator In this study, near‐infrared fluorescent...
Abstract Background Mammalian intestinal epithelium constantly undergoes rapid self-renewal and regeneration sustained by stem cells (ISCs) within crypts. Inducible nitric oxide synthase (iNOS) is an important regulator in tissue homeostasis inflammation. However, the functions of iNOS on ISCs have not been clarified. Here, we aimed to investigate expression pattern inducible crypts explore its function homeostatic maintenance ISC niche. Methods Expression was determined staining qPCR. −/−...
Near-infrared (NIR) fluorescent agents hold great promise for noninvasive in vivo imaging. We have recently reported that a NIR heptamethine dye, IR-780 iodide, exhibits unique optical properties biomedical On the basis of this foregoing work, we further describe here potential application iodide as novel agent stem cell labeling and tracking. The efficiency, subcellular localization, effects on viability differentiation were investigated. distribution cells after intravenous transplantation...
Interstitial cells of Cajal (ICCs) in gastrointestinal tract are specialized serving as pacemaker cells. The origin ICCs is currently not fully characterized. In this work, we aimed to study whether bone marrow-derived (BMDCs) could contribute the muscular plexus small intestine using GFP-C57BL/6 chimeric mice.Engraftment BMDCs was investigated for GFP expression. positive marrow mononuclear reached a proportion of<mml:math...
Abstract Progressive liver disease is a major health issue for which no effective treatment available, leading to cirrhosis and orthotopic transplantation. However, the lack of availability donor organs other adverse factors including rejection limit its extensive clinical application. Cell-based therapy using mesenchymal stem/stromal cells (MSCs) may represent an attractive therapeutic option. Dermal-derived (DMCs) are as one abundant sources from isolate applications can be easily accessed...