A5100773924- Protein Hydrolysis and Bioactive Peptides
- Tannin, Tannase and Anticancer Activities
- Enzyme Catalysis and Immobilization
- Parathyroid Disorders and Treatments
- Platelet Disorders and Treatments
- Cancer Diagnosis and Treatment
- Liver physiology and pathology
- Acute Myeloid Leukemia Research
- melanin and skin pigmentation
- Effects of Radiation Exposure
- Immune Cell Function and Interaction
- Petroleum Processing and Analysis
- Atherosclerosis and Cardiovascular Diseases
- Water Quality Monitoring Technologies
- Systemic Lupus Erythematosus Research
- Enzyme Production and Characterization
- Hematopoietic Stem Cell Transplantation
- Hair Growth and Disorders
- Chemotherapy-induced cardiotoxicity and mitigation
- Ocular Surface and Contact Lens
- Chronic Kidney Disease and Diabetes
- Inflammasome and immune disorders
- Liver Disease Diagnosis and Treatment
- Sunflower and Safflower Cultivation
- IL-33, ST2, and ILC Pathways
Zhongkai University of Agriculture and Engineering
2025
Dalian Polytechnic University
2022-2025
Army Medical University
2017-2024
Sichuan Agricultural University
2024
Northwest A&F University
2023-2024
Shanxi Medical University
2023
Wuhan University
2021
Abstract Chronic kidney disease (CKD) is associated with accelerated atherosclerosis progression and high incidence of cardiovascular events, hinting that atherosclerotic plaques in CKD may be vulnerable. However, its cause mechanism remain obscure. Here, it shown apolipoprotein E‐deficient (ApoE −/− ) mouse (CKD/ApoE mouse) a useful model for investigating the pathogenesis plaque vulnerability, premature senescence phenotypic switching vascular smooth muscle cells (VSMCs) contributes to...
Phospholipid complexes of alkyl gallates (A-GAs) including ethyl gallate (EG), propyl (PG), and butyl (BG) were successfully prepared by the thin film dispersion method. HPLC-UV analysis in an everted rat gut sac model indicated that A-GAs can be liberated from phospholipid complexes, which further hydrolyzed intestinal lipase to generate free gallic acid (GA). Both GA are able cross membrane, hydrolysis rate transport positively correlated with chain length. Especially, compared...
The composition and origin of extrinsic cues required for hematopoietic stem cell (HSC) maintenance are incompletely understood. Here we identify renal Klotho inorganic phosphate (Pi) as factors that antagonistically regulate HSC in the bone marrow (BM). Disruption Klotho-Pi axis by deficiency or Pi excess causes overload BM niche retention HSCs, leading to alteration maintenance. Mechanistically, is mediated soluble carrier family 20 member 1 (SLC20A1) sensed diphosphoinositol...
The increasing incidence of multidrug-resistant Acinetobacter baumannii (MDRAb) infections worldwide has necessitated the development novel antibiotics. Human defensin 5 (HD5) is an endogenous peptide with a complex architecture and antibacterial activity against MDRAb In present study, we attempted to simplify structure HD5 by removing disulfide bonds. We found that Cys2-4 bond was most indispensable for inactivate MDRAb, although derivative significantly attenuated. then replaced...
Cancer-associated fibroblasts (CAFs) are abundantly infiltrated in oral squamous cell carcinoma (OSCC), but the contact-dependent mechanisms that regulate CAFs phenotype precursor cells, such as paracancerous (PFs), remain unclear. Here, a fibroblast-attached organoid (FAO) model was initiated to determine transition of triggered by contact with OSCC.Organoids and were generated using OSCC adjacent tissues. Cell-clusters containing tumour cells aggregated allow for FAOs expansion....
Myelosuppression is a common and intractable side effect of cancer therapies including radiotherapy chemotherapy, while the underlying mechanism remains incompletely understood. Here, using mouse model radiotherapy-induced myelosuppression, we show that inorganic phosphate (Pi) metabolism acutely inhibited in hematopoietic stem cells (HSCs) during irradiation-induced closely correlated with severity prognosis myelosuppression. Mechanistically, acute Pi metabolic inhibition HSCs results from...
Phenolipids such as alkyl gallates (A-GAs) have been approved by the food industry non-toxic antioxidant additives, which are also regarded an emerging source of functional ingredients. However, comprehensive understanding their digestive absorption is needed. Thus, models live mice and anaerobic fermentation were used to clarify distribution microbial hydrolysis characteristics A-GAs in gastrointestinal tract. HPLC-UV results demonstrated that could be hydrolyzed intestinal lipases gut...
Dopamine (DA), a catecholamine neurotransmitter, is known to for its diverse roles on hematopoiesis, yet function in thrombopoiesis remains poorly understood. This study shows that DA stimulation can directly induce platelet production from megakaryocytes (MKs) the final stages of via reactive oxygen species (ROS)-dependent pathway. The mechanism was suggested by results treatment could significantly elevate ROS levels MKs, and time-dependently activate oxidative stress-mediated signaling,...
Cashmere, named as "soft gold", derives from the secondary hair follicles (SHFs) of cashmere goat which is vital to Northwest China's economy. The cytodifferentiation stage (E120), mirroring complete follicle (HF) structure adult goats and marking a critical phase in SHF development. Therefore, this study aims enhance understanding development its impact on fiber quality, informing breeding strategies.