A5011426710- Hematopoietic Stem Cell Transplantation
- Parathyroid Disorders and Treatments
- Platelet Disorders and Treatments
- Acute Myeloid Leukemia Research
- Epigenetics and DNA Methylation
- Inflammasome and immune disorders
- Immune Cell Function and Interaction
- Hemoglobinopathies and Related Disorders
- Circular RNAs in diseases
- Erythrocyte Function and Pathophysiology
- Antiplatelet Therapy and Cardiovascular Diseases
- Lipid metabolism and disorders
- Cancer-related molecular mechanisms research
- Atherosclerosis and Cardiovascular Diseases
- MicroRNA in disease regulation
- S100 Proteins and Annexins
- T-cell and B-cell Immunology
- Circadian rhythm and melatonin
- Chronic Kidney Disease and Diabetes
- Effects of Radiation Exposure
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Dietary Effects on Health
- Ginseng Biological Effects and Applications
- Protease and Inhibitor Mechanisms
Army Medical University
2016-2025
Nanomed (Brazil)
2019
General Department of Preventive Medicine
2019
Qinghai University
2019
Xuzhou Central Hospital
2016
Cadmium (Cd) is a persistent environmental and occupational contaminant that accumulates in the liver induces oxidative stress inflammation. Melatonin possesses potent hepatoprotective properties against development progression of acute chronic injury. Nevertheless, molecular mechanism underlying protective effects melatonin Cd-induced hepatotoxicity remains obscure. In this study, we aimed to investigate on inflammation hepatocyte death. Male C57BL/6 mice were intraperitoneally injected...
Autologous platelet membrane camouflage improves the bioavailability of mesoporous silica-coated bismuth sulfide nanorods in tumor radio-photothermal synergistic therapy.
Abstract Chronic kidney disease (CKD) is associated with accelerated atherosclerosis progression and high incidence of cardiovascular events, hinting that atherosclerotic plaques in CKD may be vulnerable. However, its cause mechanism remain obscure. Here, it shown apolipoprotein E‐deficient (ApoE −/− ) mouse (CKD/ApoE mouse) a useful model for investigating the pathogenesis plaque vulnerability, premature senescence phenotypic switching vascular smooth muscle cells (VSMCs) contributes to...
There is growing appreciation that hematopoietic alterations underpin the ubiquitous detrimental effects of metabolic disorders. The susceptibility bone marrow (BM) hematopoiesis to perturbations cholesterol metabolism well documented, while underlying cellular and molecular mechanisms remain poorly understood. Here we reveal a distinct heterogeneous signature within BM stem cells (HSCs). We further show directly regulates maintenance lineage differentiation long-term HSCs (LT-HSCs), with...
Chronic kidney disease (CKD) is well recognized as a distinct contributor to cardiac hypertrophy, while the underlying mechanism remains incompletely understood. Here, authors show that myocardial mitochondrial oxidative damage early and prominent in CKD distinctively stimulates STING-NFκB pathway by releasing DNA drive hypertrophy. Furthermore, reveal ornithine decarboxylase (ODC1)-putrescine metabolic flux transactivated NFκB required for Finally, genetic or pharmacologic inhibition of...
Abstract Cardiorenal syndrome type 4 (CRS4) is a common complication of chronic kidney disease (CKD), but the pathogenic mechanisms remain elusive. Here we report that morphological and functional changes in myocardial mitochondria are observed CKD mice, especially decreases oxidative phosphorylation fatty acid metabolism. High phosphate (HP), hallmark CKD, contributes to energy metabolism dysfunction by downregulating peroxisome proliferator-activated receptor gamma coactivator 1 alpha...
Abstract Background Hematopoietic stem cell (HSC) regeneration underlies hematopoietic recovery from myelosuppression, which is a life-threatening side effect of cytotoxicity. HSC niche profoundly disrupted after myelosuppressive injury, while if and how the reshaped regulates are poorly understood. Methods A mouse model radiation injury-induced myelosuppression was built by exposing mice to sublethal dose ionizing radiation. The dynamic changes in number, distribution functionality HSCs...
Megakaryocytes (MKs) are canonically viewed as specialized hematopoietic cells merely producing platelets and generated through a series of stem progenitor in the bone marrow (BM). Despite essential physiological functions, generation function MKs remain incompletely understood. Recent studies, almost mice, have begun to redefine cellular hierarchy megakaryopoiesis, shed new light on alternative routes mechanisms megakaryopoiesis. Moreover, conception homogenous cell population with sole...
The composition and origin of extrinsic cues required for hematopoietic stem cell (HSC) maintenance are incompletely understood. Here we identify renal Klotho inorganic phosphate (Pi) as factors that antagonistically regulate HSC in the bone marrow (BM). Disruption Klotho-Pi axis by deficiency or Pi excess causes overload BM niche retention HSCs, leading to alteration maintenance. Mechanistically, is mediated soluble carrier family 20 member 1 (SLC20A1) sensed diphosphoinositol...
Long-term hematopoietic output is dependent on stem cell (HSC) homeostasis which maintained by a complex molecular network. Among these, microRNAs play crucial roles, while the underlying basis has not been fully elucidated. Here, we show that miR-21 enriched in murine HSCs, and mice with conditional knockout of exhibit an obvious perturbation normal hematopoiesis. Moreover, significant loss HSC quiescence long-term reconstituting ability are observed absence miR-21. Further studies reveal...
The essential roles of platelets in thrombosis have been well recognized. Unexpectedly, is prevalent during thrombocytopenia induced by cytotoxicity biological, physical and chemical origins, which could be suffered military personnel civilians chemical, radioactive, nuclear events. Especially, considered a major cause mortality from radiation injury-induced thrombocytopenia, while the underlying pathogenic mechanism remains elusive. A mouse model was built exposing mice to sublethal dose...
A growing body of evidence indicates that S100 calcium‑binding protein A8 (S100A8) is frequently overexpressed in malignant tumor tissues and regulates progression; however, the role S100A8 cholangiocarcinoma (CCA) remains unclear. The present study demonstrated expression was significantly higher pathological compared with adjacent normal from patients CCA. In addition, associated differentiation, lymph node metastasis poor prognosis following surgical resection Furthermore, both vitro vivo...
Hematopoietic stem cells (HSCs) establish the entire hematopoietic system and maintain lifelong hematopoiesis. Previous studies have reported significance of microRNAs (miRNAs) in regulation self-renewal differentiation HSCs. In this study, we show that expression miRNA 34a (miR-34a) is markedly up-regulated HSCs from mice subjected to ionizing radiation (IR). Reduced numbers DNA damage repair, as well increased apoptosis, are observed miR-34a–deficient induced by irradiation, although...
Abstract Melatonin (MT), endogenously secreted by the pineal gland, is closely related to multiple biological processes; however, its effect on thrombopoiesis still not well illustrated. Here, we demonstrate that MT administration can elevate peripheral platelet levels. Analysis of different stages in reveals has capacity promote expansion CD34 + and CD41 cells, accelerate proplatelet formation (PPF) production. Furthermore, vivo experiments show a potential therapeutic radiation‐induced...