A5051142197- Wound Healing and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Advanced Glycation End Products research
- Redox biology and oxidative stress
- Metabolism, Diabetes, and Cancer
- Bee Products Chemical Analysis
- Dermatologic Treatments and Research
- Aldose Reductase and Taurine
- Lung Cancer Diagnosis and Treatment
- Laser Applications in Dentistry and Medicine
- Urinary Bladder and Prostate Research
- Nanoplatforms for cancer theranostics
- Animal Virus Infections Studies
- Nerve injury and regeneration
- Spectroscopy Techniques in Biomedical and Chemical Research
- Circadian rhythm and melatonin
- Virus-based gene therapy research
- Planarian Biology and Electrostimulation
- Autophagy in Disease and Therapy
- Biochemical effects in animals
- Effects of Radiation Exposure
- Cancer-related Molecular Pathways
- Radiation Therapy and Dosimetry
- Cardiac Ischemia and Reperfusion
- Electron Spin Resonance Studies
Army Medical University
2019-2023
Chongqing Medical University
2021
There is an urgent but unmet need for mitigating radiation-induced intestinal toxicity while radio sensitising tumours abdominal radiotherapy. We aimed to investigate the effects of metformin on and radiosensitivity colorectal tumours.Acute chronic histological injuries intestine from mice were used assess radioprotection IEC-6 cell line was mechanisms in vitro. The fractionated radiation model HCT116 HT29 tumour grafts determine cancer.Metformin alleviated acute by optimising mitophagy...
Rationale: Fibroblasts, the predominant cell type responsible for tissue fibrosis, are heterogeneous, and targeting of unique fibrogenic population fibroblasts is highly expected. Very recently, elevated glycolysis demonstrated to play a pivotal role in determination phenotype fibroblasts. However, it lack specific strategies elimination such populations. In this study, novel strategy use near-infrared (NIR) dye IR-780 glycolytic control cutaneous scarring developed. Methods: The...
Cutaneous wound healing requires intricate synchronization of several key processes. Among them, local nerve regeneration is known to be vitally important for proper repair. However, the underlying mechanisms are still unclear. Fibroblasts one cell types within skin whose role in has not been extensively studied. In our study, we found fibroblasts were tight contact with regenerated nerves during healing, while rare interactions shown under normal circumstances. Moreover, surrounding...
This study aimed to evaluate the therapeutic effect of IR-61, a novel mitochondrial heptamethine cyanine dye with antioxidant effects, on diabetes mellitus-induced erectile dysfunction (DMED). Eight-week-old male Sprague–Dawley rats were intraperitoneally injected streptozotocin (STZ) induce type 1 diabetes. Eight weeks after STZ injection, all divided into three groups: control group, DM and + IR-61 group. In administered (1.6 mg kg −1 ) twice week by intravenous injection. At 13, function...
Diabetic bladder dysfunction (DBD) afflicts nearly half of diabetic patients, but effective treatment is lacking. In this study, IR-61, a novel heptamethine cyanine dye with potential antioxidant effects, was investigated to determine whether it can alleviate DBD. Rats were intraperitoneally injected IR-61 or vehicle after diabetes induced streptozotocin. Before evaluating the effects in improving DBD by filling cystometry, we detected its distribution tissues and subcellular organelles...
Abstract To rescue ischemic myocardium from progressing to myocardial infarction, timely identification of the infarct size and reperfusion is crucial. However, fast accurate identification, as well targeted protection injured cardiomyocytes following ischemia/reperfusion (I/R) injury, remain significantly challenging. Here, a near infrared heptamethine dye IR‐780 shown that has potential quickly monitor area at risk I/R injury by selectively entering at‐risk heart tissues. Preconditioning...