A5021356552- Mesenchymal stem cell research
- Wound Healing and Treatments
- Pesticide Exposure and Toxicity
- Hematopoietic Stem Cell Transplantation
- Cancer-related molecular mechanisms research
- Chronic Lymphocytic Leukemia Research
- MicroRNA in disease regulation
- Angiogenesis and VEGF in Cancer
- Lymphoma Diagnosis and Treatment
- Cancer Cells and Metastasis
- Heme Oxygenase-1 and Carbon Monoxide
- Platelet Disorders and Treatments
- Autophagy in Disease and Therapy
- Tissue Engineering and Regenerative Medicine
- Acute Lymphoblastic Leukemia research
- Mitochondrial Function and Pathology
- Parkinson's Disease Mechanisms and Treatments
- Circular RNAs in diseases
- Retinoids in leukemia and cellular processes
- Sirtuins and Resveratrol in Medicine
- Acute Myeloid Leukemia Research
- Cytokine Signaling Pathways and Interactions
- Ubiquitin and proteasome pathways
- Carcinogens and Genotoxicity Assessment
- DNA Repair Mechanisms
Army Medical University
2015-2024
Henan Provincial People's Hospital
2023
State Council of the People's Republic of China
2019
Xinqiao Hospital
2001-2015
Scripps Research Institute
2010
Cornell University
2010
Stanford University
2010
Stanford Medicine
2010
Southwest Hospital
2009
It has been confirmed that mitochondrial impairment may underlie both sporadic and familial Parkinson’s disease (PD). Mitochondrial fission/fusion biogenesis are key processes in regulating homeostasis. Therefore, we explored whether the protective effect of resveratrol rotenone‐induced neurotoxicity was associated with biogenesis. The results showed could not only promote mass DNA copy number but also improve homeostasis neuron function rats PC12 cells damaged by rotenone. We observed...
Abstract Nitrogen mustard (NM) causes severe skin injury with an obvious inflammatory response, which is lack of effective and targeted therapies. Vitamin D3 (VD3) has excellent anti‐inflammatory properties considered as a potential candidate for the treatment NM‐induced dermal toxicity; however, underlying mechanisms are currently unclear. Cyclooxygenase‐2 (COX2; widely used marker inflammation) plays key role in cutaneous inflammation. Herein, we initially confirmed that NM markedly...
Abstract Nitrogen mustard (NM) causes severe vesicating skin injury, which lacks effective targeted therapies. The major limitation is that the specific mechanism of NM-induced injury not well understood. Recently, autophagy has been found to play important roles in physical and chemical exposure-caused cutaneous injuries. However, whether contributes dermal toxicity unclear. Herein, we initially confirmed NM dose-dependently caused cell death induced keratinocytes. Suppression by...
Immune thrombocytopenia (ITP) is an autoimmune disease which arises due to self-destruction of circulating platelets. Failure respond or maintain a response first-line treatment can lead refractory/relapsed (R/R) ITP. The mechanism remains complicated and lacks standard clinical treatment. Sirolimus (SRL) mammalian target rapamycin (mTOR) inhibitor that has been demonstrated inhibit lymphocyte activity, indicating potential for SRL in Activation the mTOR pathway diseases suggests might be...
Objectives To investigate the role of pericytes in constructing malformed microvessels (MVs) and participating microvascular architecture heterogeneity glioma. Methods Forty human glioma tissue samples (WHO grade II-IV) were included present study. Observation blood vessel patterns, quantitative analysis endothelial cells (ECs)- pericyte-labeled MVs comparison between malignant grades based on single- or double-immunohistochemical staining. The MV number density (MVND), pericyte (MPND), area...
Programmed cell death 4 (PDCD4) is one multi-functional tumor suppressor inhibiting neoplastic transformation and invasion. The role of PDCD4 in tumorigenesis has attracted more attention been systematically elucidated cutaneous tumors. However, the normal biological function skin still unclear. In this study, for first time, we find that uniquely induced a density-dependent manner keratinocytes. To determine potential keratinocyte biology, show knockdown by siRNAs can promote proliferation...
ERp29 is a resident protein of the endoplasmic reticulum (ER) lumen, which thought to be involved in folding secretory proteins. In our previous work, it was found that, when treated with ionizing radiation (IR), expression increased mouse intestinal epithelia and cultured IEC-6 cells, suggested that might radiation-induced gene. The current work confirm induction by IR analyze its role irradiated cells. Our results showed elevated cells at mRNA levels time-dependent manner. different...