A5002456827- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Musculoskeletal pain and rehabilitation
- Medical Imaging and Analysis
- Cervical and Thoracic Myelopathy
- Osteoarthritis Treatment and Mechanisms
- Anesthesia and Pain Management
- Spinal Hematomas and Complications
- Pelvic and Acetabular Injuries
- Spinal Cord Injury Research
- Scoliosis diagnosis and treatment
- Mesenchymal stem cell research
- Diabetic Foot Ulcer Assessment and Management
- Cancer-related molecular mechanisms research
- Orthopaedic implants and arthroplasty
- Management of metastatic bone disease
- Tendon Structure and Treatment
- MicroRNA in disease regulation
- Nerve injury and regeneration
- Wound Healing and Treatments
- Hip and Femur Fractures
- Tissue Engineering and Regenerative Medicine
- Cardiac, Anesthesia and Surgical Outcomes
- Pregnancy-related medical research
- Plant Toxicity and Pharmacological Properties
Army Medical University
2016-2025
Xinqiao Hospital
2016-2025
Harbin Medical University
2018-2025
Chengdu University of Traditional Chinese Medicine
2021-2025
First Affiliated Hospital of GuangXi Medical University
2025
Guangxi Medical University
2025
Guangdong Pharmaceutical University
2025
Guangdong Medical College
2025
Chongqing Municipal Health Commission
2025
81th Hospital of PLA
2024
Mesenchymal stem cells (MSCs) have been reported to hold promise accelerate the wound-healing process in diabetic foot ulcer (DFU) due multilineage differentiation potential. Hence, this study intended explore wound healing role of MSC-derived exosomes containing long noncoding RNA (lncRNA) H19 DFU. lncRNA was predicated bind microRNA-152-3p (miR-152-3p), which targeted phosphatase and tensin homolog (PTEN) deleted on chromosome ten. Fibroblasts DFU samples exhibited highly expressed...
The stem cell-based therapies for intervertebral disc degeneration have been widely studied. However, the mechanisms of mesenchymal cells interacting with cells, such as nucleus pulposus (NPCs), remain unknown. Exosomes a vital paracrine mechanism in cell-cell communication highly focused on. purpose this study was to detect role exosomes derived from bone marrow (BM-MSCs) and NPCs their interaction corresponding cells.The secreted by BM-MSCs were purified differential centrifugation...
Abstract Degeneration of the cartilage endplate (CEP) induces intervertebral disc degeneration (IVDD). Nucleus pulposus cell (NPC) apoptosis is also an important exacerbating factor in IVDD, but cascade mechanism IVDD not clear. We investigated NPCs and when stimulated by normal stem (CESC)-derived exosomes (N-Exos) degenerated CESC-derived (D-Exos) vitro vivo. Tert-butyl hydroperoxide (TBHP) was used to induce inflammation CESCs. The bioinformatics differences between N-Exos D-Exos were...
Object The main objective of this study was to analyze the epidemiological data obtained from patients with traumatic spinal fracture at 2 university-affiliated hospitals in Chongqing, China. Methods authors retrospectively reviewed hospital records all who suffered and were treated Xinqiao Hospital Southwest (both affiliated Third Military Medical University) between January 2001 December 2010. demographic characteristics, injury clinical outcomes over 10-year period compared. Results A...
Radiotherapy to cancer patients is inevitably accompanied by normal tissue injury, and the bone one of most commonly damaged tissues. Damage marrow mesenchymal stem cells (BM-MSCs) induced radiation thought be a major cause radiation-induced loss. Exosomes exhibit great therapeutic potential in treatment osteoporosis, but whether exosomes are involved loss has not been thoroughly elucidated date. The main purpose this study investigate role derived from BM-MSCs restoring recipient BM-MSC...
Mesenchymal stem cells (MSCs) derived from adult tissues are an important candidate for cell-based therapies and regenerative medicine due to their multipotential differentiation capability. MSCs have been identified in many but not reported the human intervertebral disc cartilage endplate (CEP). The initial purpose of this study was determine whether exist degenerated CEP. Next, morphology, proliferation capacity, cell cycle, surface epitope profile capacity these CEP-derived (CESCs) were...
Study Design: We retrospectively reviewed 100 patients who were posterior stabilized without graft fusion. Using the Sextant system, 22 underwent minimally invasive short-segment 4-pedicle screw fixation (MIF4) and 39 combined with intermediate screws fixation, that is, 6-pedicle (MIF6). The conventional open (OPF4) technique was used in patients. Objective: To evaluate feasibility, safety, efficacy of percutaneous pedicle using system treatment traumatic thoracolumbar fractures compared...
International consensus paper on a unified nomenclature for full-endoscopic spine surgery.Minimally invasive endoscopic spinal procedures have undergone rapid development during the past decade. Evolution of working-channel endoscopes and surgical instruments as well innovation in techniques expanded types pathology that can be addressed. However, there is literature heterogeneous defining approach corridors procedures, this lack common language has hampered communication between surgeons,...
Postoperative epidural adhesion remains a clinically challenging problem in spine surgery. Currently there are no effective and safe antifibrotic antiadhesion biomaterials that have been specifically developed for this complication clinical practice. Herein we designed engineered an advanced hydrogel with multiple functionalities, including temperature-responsive gelation, self-healing, tissue adhesiveness, antioxidation, anti-inflammation, antifibrosis. This multifunctional supramolecular...
Low back pain, mainly caused by intervertebral disc degeneration (IVDD), is a common health problem; however, current surgical treatments are less than satisfactory. Thus, it essential to develop novel non-invasive methods for IVDD treatment. Here, we describe therapeutic strategy inhibit injecting hydrogels modified with the extracellular matrix of costal cartilage (ECM-Gels) that loaded endplate stem cells (CESCs). After CESCs overexpressing Sphk2 (Lenti-Sphk2-CESCs) and injected near...
Study Design: This is a prospective single-center nonrandomized control clinical study involving 81 overweight or obese patients who underwent minimally invasive open transforaminal lumbar interbody fusion (TLIF). Objective: The objective of this was to evaluate the safety and efficacy TLIF as an alternative technique in patients. Summary Background Data: Spinal surgery associated with increased complications, blood loss, operative times. potential benefits have been discussed few studies....