A5100356190- Mesenchymal stem cell research
- MicroRNA in disease regulation
- Tissue Engineering and Regenerative Medicine
- Neonatal Respiratory Health Research
- Pluripotent Stem Cells Research
- Bone Metabolism and Diseases
- Congenital Diaphragmatic Hernia Studies
- Childhood Cancer Survivors' Quality of Life
- Bone fractures and treatments
- Hematopoietic Stem Cell Transplantation
- Osteoarthritis Treatment and Mechanisms
- Tendon Structure and Treatment
- Electrospun Nanofibers in Biomedical Applications
- Circular RNAs in diseases
- Hedgehog Signaling Pathway Studies
- Noise Effects and Management
- TGF-β signaling in diseases
- Craniofacial Disorders and Treatments
- Angiogenesis and VEGF in Cancer
- Extracellular vesicles in disease
- Neurogenesis and neuroplasticity mechanisms
- Nerve injury and regeneration
- Immune cells in cancer
- Diabetic Foot Ulcer Assessment and Management
- Telomeres, Telomerase, and Senescence
Sichuan University
2016-2025
West China Second University Hospital of Sichuan University
2018-2025
Chinese University of Hong Kong
2012-2025
Nanchang University
2021-2025
Wuhan General Hospital of Guangzhou
2025
South China University of Technology
2023-2025
First Hospital of Jilin University
2025
Jilin University
2025
Fudan University
2024
Zhejiang Chinese Medical University
2024
Background Hypertension is a major risk factor for cardiovascular disease and all‐cause mortality. Compared with prior guidelines, the 2017 American College of Cardiology/American Heart Association (ACC/AHA) hypertension guideline recommends lower blood pressure thresholds defining hypertension, initiating antihypertensive medication, medication treatment goals. Methods Results To better understand potential impacts guideline, we studied trends in mean systolic diastolic , prevalence burden...
Electrospun scaffolds have been broadly studied to enhance bone regeneration because of the ability simulate structure and biological functions extracellular matrix. Polydopamine (PDA) is used coat various surfaces at a slightly basic pH (8-8.5) spontaneously reacts with nucleophilic functional groups. It suitable for surface modifications correlated formation. E7 newly discovered peptide specific affinity marrow mesenchymal stem cells (BMSCs). can be useful recruiting cells. Here,...
Human mesenchymal stem cells (hMSCs) are currently investigated for a variety of therapeutic applications. However, MSCs isolated from primary tissue cannot meet clinical grade needs and should be expanded in vitro several passages. Although hMSCs show low possibility undergoing oncogenic transformation, they do, similar to other somatic cells, undergo cellular senescence their potential is diminished when cultured vitro. the role senescent tumor progression remains largely elusive. In...
Interstitial lung disease (ILD) may cause life-threatening complications of primary Sjogren's syndrome (pSS), and has a poor prognosis in terms survival quality life. To date, few studies have investigated the risk factors for ILD detected by high-resolution computed tomography (HRCT) pSS patients with or without respiratory symptoms.Data 333 newly diagnosed were retrospectively analysed. involvement was defined as typical abnormalities on HRCT and/or pulmonary function tests. Multivariate...
At a certain point in development, axons the mammalian central nervous system lose their ability to regenerate after injury. Using optic nerve model, we show that this growth failure coincides with two developmental events: loss of Bcl-2 expression by neurons and maturation astrocytes. Before postnatal day 4, when astrocytes are immature, overexpression alone supported robust rapid regeneration over long distances, leading innervation brain targets 4 mice. As matured axonal was inhibited...
Abstract The aim of this study is to investigate the feasibility using well defined, serum‐free freezing solutions with a reduced level dimethylsulfoxide (DMSO) 7.5, 5, and 2.5% (v/v) in combination polyethylene glycol (PEG) or trehalose cryopreserve human bone marrow‐derived mesenchymal stem cells (hBMSCs), main source for cell therapy tissue engineering. standard laboratory protocol around 1°C/min was used experiments. efficiency 1,2‐propandiol on cryopreservation hBMSCs explored. We...
Tendon injures are common orthopedic conditions, but tendon development and the pathogenesis of injures, such as tendinopathy, remain largely unknown have limited clinical therapy. Studies on tenogenic differentiation at molecular level may help in developing novel therapeutic strategies. As regulators, long noncoding RNAs (lncRNAs) been found to widespread biological functions, emerging evidence demonstrates that lncRNAs play important regulatory roles cell tissue regeneration. In this...
Urethral reconstruction is one of the great surgical challenges for urologists. A cell-based tissue-engineered urethra may be an alternative patients who have complicated long strictures and need urethral reconstruction. Here, we demonstrated feasibility using autologous urine-derived stem cells (USCs) seeded on small intestinal submucosa (SIS) to repair a defect in rabbit model. Autologous USCs were obtained characterized, their capacity differentiate into urothelial (UCs) smooth muscle...
Mesenchymal stem cells (MSCs) are a promising cell resource for tissue engineering. Sry-related high-mobility group box 11 (Sox11) plays critical roles in neural development and organogenesis. In the present study, we investigated role of Sox11 regulating trilineage differentiation (osteogenesis, adipogenesis, chondrogenesis) migration MSCs, explored effect systemically administrated Sox11-modified MSCs on bone fracture healing using rat model open femur fracture. Our results demonstrated...
In order to better promote the use of mobile technology in field language education, we created an augmented reality game, Guardians Mo'o, for ESL (English as Second Language) learners enhance their cultural understanding, communicational skills and also development. Through detailed analysis video recorded play-through data, found that students were able coordinate actions engage both virtual physical world during problem-solving processes. Thus, argue embodied gaming environment which Mo'o...
Distraction osteogenesis (DO) is one of the most dramatic reconstructive techniques for inducing bone regeneration, but it involves an undesirably long period consolidation. Developing innovative approaches to enhance consolidation a burning need. Human fetal mesenchymal stem cells (hFMSCs) have been shown express more primitive developmental genes than those human adult (hAMSCs), which preferable source cell therapy and tissue regeneration. In present study, we investigated immunogenicity...
Mesenchymal stem cells (MSCs) exert a tumor-promoting effect in variety of human cancers. This study was designed to identify the molecular mechanisms related MSCs colorectal cancer. In vitro analysis cancer cell lines cultured MSC conditioned media (MSC-CM) showed that MSC-CM significantly promoted progression by enhancing proliferation, migration and colony formation. The tumorigenic attributed altered expression cycle regulatory proteins inhibition apoptosis. Furthermore, induced high...
Bone defect regeneration is a complex process that involves the coordination of variety different type cells. As bone tissues are innervated and rich in nerve fibers, neuropeptides released from various never fibers could regulate development, metabolism, remodeling. Among all neuropeptides, vasoactive intestinal peptide (VIP) modulate functions both osteoblasts osteoclasts, may play vital role marrow mesenchymal stem cell (BMSC) osteogenesis during repair. In this study, we investigated VIP...
Abstract One major limitation of neutralizing antibody-based COVID-19 therapy is the requirement costly cocktails to reduce emergence antibody resistance. Here we engineer two bispecific antibodies (bsAbs) using distinct designs and compared them with parental their cocktail. Single molecules both bsAbs block epitopes targeted by on receptor-binding domain (RBD). However, bsAb IgG-(scFv) 2 design (14-H-06) but not CrossMAb (14-crs-06) shows increased antigen-binding virus-neutralizing...
Abstract Mesenchymal stem cell‐based therapy has emerged as a promising approach for the treatment of peripheral arterial disease. The purpose this study was to examine potential effects human placenta‐derived mesenchymal cells ( PMSC s) on mouse hindlimb ischemia. s were isolated from placenta tissue and characterized by flow cytometry. An in vivo surgical ligation‐induced murine limb ischemia model generated with fluorescent dye CM ‐DiI) labelled delivered via intramuscular injection. Our...