A5100618713- Ferroptosis and cancer prognosis
- Lung Cancer Treatments and Mutations
- Epigenetics and DNA Methylation
- Immune cells in cancer
- Colorectal Cancer Treatments and Studies
- Antibiotics Pharmacokinetics and Efficacy
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- Analytical Methods in Pharmaceuticals
- Circular RNAs in diseases
- Cancer, Hypoxia, and Metabolism
- Cancer therapeutics and mechanisms
- Autophagy in Disease and Therapy
- Cancer Cells and Metastasis
- COVID-19 diagnosis using AI
- PI3K/AKT/mTOR signaling in cancer
- Urological Disorders and Treatments
- Flavonoids in Medical Research
- Pharmaceutical Practices and Patient Outcomes
- Chemotherapy-induced cardiotoxicity and mitigation
- Hormonal and reproductive studies
- Lung Cancer Research Studies
- Pediatric Urology and Nephrology Studies
- HIV/AIDS Research and Interventions
- Cancer-related molecular mechanisms research
Shanghai Jiao Tong University
2025
Tongren Hospital
2025
Harbin Medical University
2025
University of Oulu
2025
Beijing Academy of Science and Technology
2025
Institute of New Materials
2025
Gwangju Institute of Science and Technology
2024
South China University of Technology
2020-2024
Pudong Medical Center
2024
Fudan University
2024
Ferroptosis is a recently identified form of regulated cell death defined by the iron-dependent accumulation lipid reactive oxygen species. has been studied in various diseases such as cancer, Parkinson's disease, and stroke. However, exact function mechanism ferroptosis ischemia/reperfusion (I/R) injury, especially intestine, remains unknown. Considering unique conditions required for ferroptosis, we hypothesize that ischemia promotes immediately after intestinal reperfusion. In contrast to...
How cancer cells respond to nutrient deprivation remains poorly understood. In certain cells, of cystine induces a non-apoptotic, iron-dependent form cell death termed ferroptosis. Recent evidence suggests that ferroptosis sensitivity may be modulated by the stress-responsive transcription factor and canonical tumor suppressor protein p53. Using CRISPR/Cas9 genome editing, small-molecule probes, high-resolution, time-lapse imaging, we find stabilization wild-type p53 delays onset in response...
Renal tubular cell death is the key factor of pathogenesis ischemia/reperfusion (I/R) kidney injury. Ferroptosis a type regulated (RCD) found in various diseases. However, underlying molecular mechanisms related to ferroptosis renal I/R injury remain unclear. In present study, we investigated regulatory role microRNAs on I/R-induced We established model rats, and H/R induced HK-2 cells vitro. CCK-8 was used measure viability. Fe2+ ROS levels were assayed evaluate activation ferroptosis....
Abstract Emerging evidence reveals that amino acid metabolism plays an important role in ferroptotic cell death. The conversion of methionine to cysteine is well known protect tumour cells from ferroptosis upon starvation through transamination. However, whether acids‐produced metabolites participate independent the pathway largely unknown. Here, authors show tryptophan serotonin (5‐HT) and 3‐hydroxyanthranilic (3‐HA) remarkably facilitate escape distinct cysteine‐mediated inhibition....
Interstitial lung disease (ILD) may cause life-threatening complications of primary Sjogren's syndrome (pSS), and has a poor prognosis in terms survival quality life. To date, few studies have investigated the risk factors for ILD detected by high-resolution computed tomography (HRCT) pSS patients with or without respiratory symptoms.Data 333 newly diagnosed were retrospectively analysed. involvement was defined as typical abnormalities on HRCT and/or pulmonary function tests. Multivariate...
Sulforaphane (SFN), a natural anti-tumor compound from cruciferous vegetables, has been reported to induce protective autophagy cancer cells, which might impair the efficiency of SFN. However, accurate function and mechanism SFN inducing in cancers are still obscure, especially esophageal squamous cell carcinoma (ESCC), one malignancies with high incidence North China. Here, we mainly explored potential upon treatment ESCC molecular mechanism. We demonstrated that could inhibit proliferation...
Background Health services for men who have sex with (MSM) are inadequate in many areas around the world. HIV and syphilis test uptake remain suboptimal among MSM China other regions. To inform development of more comprehensive sexually transmitted disease (STD) testing programs MSM, we collected descriptive data on practices preferences. Methods two large urban Chinese cities were recruited through community-based organizations clinics to participate semi-structured interviews. We...
Abstract Doxorubicin (DOX) is a first-line chemotherapy agent known for its cardiac toxicity. DOX-induced cardiotoxicity (DIC) severely limits the use treating malignant tumors and associated with poor prognosis. The sensitivity to DIC varies among patients, but precise mechanisms remain elusive. Here we constructed mouse model of using DOX investigate potential contributing differential susceptibility DIC. Through surface-enhanced Raman spectroscopy single-cell RNA sequencing, explored...
Inhibiting ferroptosis represents a promising strategy to combat ferroptosis-related diseases. Here we show that 428, selenide-containing noscapine derivative, effectively inhibits in various cell lines by enhancing the stability and activity of GPX4. TRIM41 was identified as novel E3 ubiquitin ligase GPX4 428 demonstrated bind selenocysteine residue Sec46 via formation transient reversible Se-Se bond, thereby blocking interaction between TRIM41, stabilizing its activity. This unique dynamic...
Abstract Tumor models are important tools for cancer research and drug development. The existing tumor unable to reconstruct the microphysiological processes of immune responses in vivo, thus limiting their applications development immunological drugs immunotherapy. How rapidly accurately construct with a microenvironment an system is critical problem that urgently needs be solved field immunology therapy. In this study, innovatively based on bio-3D printing organ-on-a-chip technology, lung...
Abstract Ferroptosis is a newly identified cell death triggered by iron‐induced lipid peroxidation. Numerous studies reveal that ferroptosis participates in multiple types of tissue injury including ischaemia–reperfusion (I/R) and doxorubicin (Dox)‐induced damage. Targeting promising approach for disease treatment as the blockade efficiently alleviates symptoms. However, no known inhibitors have been used clinical treatment. Although certain compounds act vitro, whether these drugs cure...
The present study aimed to investigate the toxicity of microcystin-LR (MC-LR) and explore mechanism MC-LR-induced apoptosis in human bronchial epithelial (HBE) cells. HBE cells were treated with MC-LR (1, 10, 20, 30 40 µg/ml) alone or (0, 2.5, 5 10 Z-VAD-FMK 40, 60, 80, 100, 120 140 µM), which is a caspase inhibitor, for 24 48 h. Cell viability was assessed via an MTT assay half maximal effective concentration determined. optimal established as 50 µm, then used subsequent experiments....
ABSTRACT Non-small cell lung cancer (NSCLC) accounts for the majority of all cases, which is leading cause deaths worldwide. IL-17░A, major effector cytokine derived from Th17 cells, a key in tumor pathogenesis and modulates progression. We aimed to identify whether IL-17░A cells promotes progression NSCLC. Here we found that level was increased NSCLC mainly produced by CD4+ (Th17 cells) enhanced migration, invasion stemness via STAT3/NF-κB/Notch1 signaling. Blockade this signaling inhibited...
Abstract Osimertinib is an oral, irreversible, central nervous system active epidermal growth factor receptor (EGFR)–tyrosine kinase inhibitor (TKI) selective for both EGFR‐TKI sensitizing and T790M resistance mutations. The study's (NCT02529995) primary objective was to characterize the pharmacokinetics (PK) of osimertinib its metabolites in Chinese patients enrolled China. PK assessed following single multiple doses 40 or 80 mg once daily. Patients were aged ≥ 18 years with locally...
COVID-19 causes burdens to the ICU. Evidence-based planning and optimal allocation of scarce ICU resources is urgently needed but remains unaddressed. This study aims identify variables test accuracy predict need for admission, death despite care, among survivors, length stay, before patients were admitted Retrospective data from 733 in-patients confirmed with COVD-19 in Wuhan, China, as March 18, 2020. Demographic, clinical laboratory collected analyzed using machine learning build...