A5087965203- Cancer, Stress, Anesthesia, and Immune Response
- Immune Cell Function and Interaction
- Immune cells in cancer
- Electron Spin Resonance Studies
- Hippo pathway signaling and YAP/TAZ
- RNA Research and Splicing
- Cancer Treatment and Pharmacology
- Fiscal Policy and Economic Growth
- Energy, Environment, Economic Growth
- Groundwater and Isotope Geochemistry
- Cell death mechanisms and regulation
- Chemokine receptors and signaling
- Stress Responses and Cortisol
- Environmental and Agricultural Sciences
- Geochemistry and Geologic Mapping
- Chemotherapy-induced cardiotoxicity and mitigation
- Geoscience and Mining Technology
- Hydrology and Watershed Management Studies
Second Affiliated Hospital of Harbin Medical University
2025
Harbin Medical University
2025
Shenzhen MSU-BIT University
2024
Xuzhou Medical College
2024
China University of Geosciences (Beijing)
2008
Ministry of Housing and Urban-Rural Development
1997
Abstract As understanding of cancer has deepened, increasing attention been turned to the roles psychological factors, especially chronic stress–induced depression, in occurrence and development tumors. However, whether how depression affects progression gliomas are still unclear. In this study, we have revealed that stress inhibited recruitment tumor-associated macrophages (TAM) other immune cells, M1-type TAMs CD8+ T decreased level proinflammatory cytokines gliomas, leading an...
Abstract Doxorubicin (DOX) is a first-line chemotherapy agent known for its cardiac toxicity. DOX-induced cardiotoxicity (DIC) severely limits the use treating malignant tumors and associated with poor prognosis. The sensitivity to DIC varies among patients, but precise mechanisms remain elusive. Here we constructed mouse model of using DOX investigate potential contributing differential susceptibility DIC. Through surface-enhanced Raman spectroscopy single-cell RNA sequencing, explored...
In the critical stage of China's economic development towards "risk prevention" and "stable growth", importance preventing debt risk incentivizing business innovation has gradually become more prominent, so it is necessary to study impact local government (LGD) on innovation. Based existing studies relationship between LGD innovation, this paper summarizes analyzes them in an attempting clarify mechanisms through which acts The shows that crowds out enterprise research (R&D) investment...
The Hippo pathway is a conserved tumour suppressor signalling pathway, and its dysregulation often associated with abnormal cell growth tumorigenesis. We previously revealed that the transcriptional coactivator Yes-associated protein (YAP), key effector of molecular target for glioblastoma (GBM), most common malignant brain tumour. Inhibiting YAP small interfering RNA (siYAP) or specific inhibitor verteporfin (VP) can diminish GBM to certain degree.
<p>Supplementary Figure 6. CCL3 treatment improves the migration of TAMs in vitro and immune microenvironment gliomas caused by chronic stress vivo (Related to Fig.5)</p>
<p>Supplementary Figure 4. Chronic stress inhibited migration ability of TAMs (Related to Fig.4)</p>
<p>Supplementary Figure 7. The expression of CCR1 and CCR5 in cell subtypes glioma tissues analyzed by single-cell sequencing</p>
<p>Supplementary Figure 1. Successful construction of the mice model for depression (Related to Fig.1)</p>
<p>Supplementary Figure 4. Chronic stress inhibited migration ability of TAMs (Related to Fig.4)</p>
<p>Supplementary Figure 3. Blocking the stress reverses levels of IFN-γ and GZMB in gliomas (Related to Fig.3)</p>
<p>Supplementary Figure 2. Chronic stress exacerbates the formation of immunosuppressive microenvironment in gliomas (Related to Fig.2)</p>
<p>Supplementary Figure 2. Chronic stress exacerbates the formation of immunosuppressive microenvironment in gliomas (Related to Fig.2)</p>
<p>Supplementary Figure 1. Successful construction of the mice model for depression (Related to Fig.1)</p>
<p>Supplementary Figure 3. Blocking the stress reverses levels of IFN-γ and GZMB in gliomas (Related to Fig.3)</p>
<p>Supplementary Figure 6. CCL3 treatment improves the migration of TAMs in vitro and immune microenvironment gliomas caused by chronic stress vivo (Related to Fig.5)</p>
<p>Supplementary Figure 5. Chronic stress inhibits the secretion of CCL3/4 (Related to Fig.4)</p>
<div>Abstract<p>As understanding of cancer has deepened, increasing attention been turned to the roles psychological factors, especially chronic stress–induced depression, in occurrence and development tumors. However, whether how depression affects progression gliomas are still unclear. In this study, we have revealed that stress inhibited recruitment tumor-associated macrophages (TAM) other immune cells, M1-type TAMs CD8<sup>+</sup> T decreased level proinflammatory...
<div>Abstract<p>As understanding of cancer has deepened, increasing attention been turned to the roles psychological factors, especially chronic stress–induced depression, in occurrence and development tumors. However, whether how depression affects progression gliomas are still unclear. In this study, we have revealed that stress inhibited recruitment tumor-associated macrophages (TAM) other immune cells, M1-type TAMs CD8<sup>+</sup> T decreased level proinflammatory...
<p>Supplementary Figure 5. Chronic stress inhibits the secretion of CCL3/4 (Related to Fig.4)</p>
<p>Supplementary Figure 7. The expression of CCR1 and CCR5 in cell subtypes glioma tissues analyzed by single-cell sequencing</p>