A5018166161- Cancer, Stress, Anesthesia, and Immune Response
- Immune cells in cancer
- Immune Cell Function and Interaction
- Heavy Metal Exposure and Toxicity
- Air Quality and Health Impacts
- Cardiovascular Health and Risk Factors
- Chemokine receptors and signaling
- Hippo pathway signaling and YAP/TAZ
- Obesity, Physical Activity, Diet
- Microtubule and mitosis dynamics
- Stress Responses and Cortisol
- Ubiquitin and proteasome pathways
- Birth, Development, and Health
- Health, Environment, Cognitive Aging
Xuzhou Medical College
2022-2024
Wenzhou City People's Hospital
2024
Wenzhou Hospital of Traditional Chinese Medicine
2024
Abstract As understanding of cancer has deepened, increasing attention been turned to the roles psychological factors, especially chronic stress–induced depression, in occurrence and development tumors. However, whether how depression affects progression gliomas are still unclear. In this study, we have revealed that stress inhibited recruitment tumor-associated macrophages (TAM) other immune cells, M1-type TAMs CD8+ T decreased level proinflammatory cytokines gliomas, leading an...
Liver transplantation (LT) is a primary treatment option for patients with end-stage liver disease. However, post-transplantation immune regulation critical to graft survival and long-term patient outcomes. Following transplantation, the recipient’s system mounts response against graft, while promotes anti-rejection reactions establishment of tolerance. In recent years, advances in study microenvironment have provided new insights into regulation. Meanwhile, immunotherapy strategies opened...
Background The association between exposure to cadmium (Cd) and cardiovascular health (CVH) has received considerable scientific interest. However, findings thus far have been inconclusive, particularly regarding sex-specific effects dose–response relationships. aim of our study was investigate the relationships blood Cd levels with overall component CVH scores. Methods We used data from 2011–2018 NHANES assess using indicators such as BMI, pressure, lipid profiles, glucose levels, diet,...
We previously report that yes-associated protein (YAP), the core downstream effector of Hippo pathway, promotes malignant progression glioblastoma (GBM). However, although classical regulatory mechanisms YAP are well explored, how is modulated by Hippo-independent manner remains poorly understood. Meanwhile, nonreceptor tyrosine kinase Fyn-related (FRK), which exhibits low expression and possesses tumor suppressor effects in GBM, reported to be involved regulation phosphorylation. Here, we...
<p>Supplementary Figure 6. CCL3 treatment improves the migration of TAMs in vitro and immune microenvironment gliomas caused by chronic stress vivo (Related to Fig.5)</p>
<p>Supplementary Figure 4. Chronic stress inhibited migration ability of TAMs (Related to Fig.4)</p>
<p>Supplementary Figure 7. The expression of CCR1 and CCR5 in cell subtypes glioma tissues analyzed by single-cell sequencing</p>
<p>Supplementary Figure 1. Successful construction of the mice model for depression (Related to Fig.1)</p>
<p>Supplementary Figure 4. Chronic stress inhibited migration ability of TAMs (Related to Fig.4)</p>
<p>Supplementary Figure 3. Blocking the stress reverses levels of IFN-γ and GZMB in gliomas (Related to Fig.3)</p>
<p>Supplementary Figure 2. Chronic stress exacerbates the formation of immunosuppressive microenvironment in gliomas (Related to Fig.2)</p>
<p>Supplementary Figure 2. Chronic stress exacerbates the formation of immunosuppressive microenvironment in gliomas (Related to Fig.2)</p>
<p>Supplementary Figure 1. Successful construction of the mice model for depression (Related to Fig.1)</p>
<p>Supplementary Figure 3. Blocking the stress reverses levels of IFN-γ and GZMB in gliomas (Related to Fig.3)</p>
<p>Supplementary Figure 6. CCL3 treatment improves the migration of TAMs in vitro and immune microenvironment gliomas caused by chronic stress vivo (Related to Fig.5)</p>
<p>Supplementary Figure 5. Chronic stress inhibits the secretion of CCL3/4 (Related to Fig.4)</p>
<div>Abstract<p>As understanding of cancer has deepened, increasing attention been turned to the roles psychological factors, especially chronic stress–induced depression, in occurrence and development tumors. However, whether how depression affects progression gliomas are still unclear. In this study, we have revealed that stress inhibited recruitment tumor-associated macrophages (TAM) other immune cells, M1-type TAMs CD8<sup>+</sup> T decreased level proinflammatory...
<div>Abstract<p>As understanding of cancer has deepened, increasing attention been turned to the roles psychological factors, especially chronic stress–induced depression, in occurrence and development tumors. However, whether how depression affects progression gliomas are still unclear. In this study, we have revealed that stress inhibited recruitment tumor-associated macrophages (TAM) other immune cells, M1-type TAMs CD8<sup>+</sup> T decreased level proinflammatory...
<p>Supplementary Figure 5. Chronic stress inhibits the secretion of CCL3/4 (Related to Fig.4)</p>
<p>Supplementary Figure 7. The expression of CCR1 and CCR5 in cell subtypes glioma tissues analyzed by single-cell sequencing</p>
This study sought to use the latest Life's Essential 8 scoring tool obtain information on relationship between serum vitamin D concentration and adolescent cardiovascular health (CVH). A total of 1,819 teenagers aged 16-19 were enrolled. Associations concentrations CVH ratings estimated using multiple linear regression multinomial logistic methods, dose-response was examined by restricted cubic spline analysis. After adjusting for all confounding factors, positively correlated with scores (β...