A5101868278- Liver Disease Diagnosis and Treatment
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Glioma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Liver Disease and Transplantation
- Hepatitis B Virus Studies
- Pituitary Gland Disorders and Treatments
- Spine and Intervertebral Disc Pathology
- Liver physiology and pathology
- Angiogenesis and VEGF in Cancer
- Hepatitis C virus research
- Galectins and Cancer Biology
- Cancer, Hypoxia, and Metabolism
- Bladder and Urothelial Cancer Treatments
- Organ Transplantation Techniques and Outcomes
- Trace Elements in Health
- Immune cells in cancer
- Meningioma and schwannoma management
- Cancer Research and Treatments
- RNA modifications and cancer
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Renal cell carcinoma treatment
- COVID-19 and healthcare impacts
Nankai University
2021-2025
Chinese Academy of Sciences
2013-2025
Institute of Zoology
2025
University of Chinese Academy of Sciences
2025
Capital Medical University
2013-2024
Beijing YouAn Hospital
2013-2024
Beijing Friendship Hospital
2021-2024
Beijing Sanbo Brain Hospital
2016-2023
Hainan General Hospital
2016-2023
Hainan Medical University
2020-2023
Background: Treatment of cancers with programmed cell death protein 1 (PD-1) pathway inhibitors can lead to immune-related adverse events (irAEs), which could be serious and even fetal. Therefore, clinicians should aware the characteristics irAEs associated use such drugs. Methods: The MEDLINE, EMBASE, Cochrane databases were searched find potential studies using following strategies: anti-PD-1/PD-L1 treatment; irAEs; cancer. R© package Meta was used pool incidence. Results: Forty-six...
Background: Since the first case of a novel coronavirus (COVID-19) infection pneumonia was detected in Wuhan, China, series confirmed cases COVID-19 were found Beijing. We analyzed data 262 to determine clinical and epidemiological characteristics Methods: collected patients who transferred by Beijing Emergency Medical Sevice designated hospitals. The information on demographic, epidemiological, clinical, laboratory test for virus, diagnostic classification, cluster outcome obtained....
Background/Aims: This study aims to investigate the role of circular antisense non-coding RNA at INK4 locus (cANRIL) in inflammatory response vascular endothelial cells (ECs) a rat model coronary atherosclerosis (AS). A AS was established with rats that were injected large dose vitamin D3 and fed high-fat diet. Methods: Sixty Wistar randomly assigned into control, model, empty vector, over-expressed cANRIL low-expressed groups (12 each group). Sixteen weeks later, ultrastructure their...
Interstitial lung disease (ILD) may cause life-threatening complications of primary Sjogren's syndrome (pSS), and has a poor prognosis in terms survival quality life. To date, few studies have investigated the risk factors for ILD detected by high-resolution computed tomography (HRCT) pSS patients with or without respiratory symptoms.Data 333 newly diagnosed were retrospectively analysed. involvement was defined as typical abnormalities on HRCT and/or pulmonary function tests. Multivariate...
Hypersplenism is a common disorder characterized by an enlarged spleen which causes rapid and premature destruction of blood cells. This review summarizes the history hypersplenism, discuss its classification pathogenesis, examines diagnosis treatment options. We performed comprehensive literature search using PubMed, Web Knowledge China National Infrastructure (CNKI) database, reviewed hypersplenism-related articles summarized major findings. According to etiological causes, hypersplenism...
Abstract Objectives Little is known about workplace measures against coronavirus disease 2019 (COVID-19) in Japan during the winter of 2020, especially micro-, small-, and medium-sized enterprises (MSMEs). This study aimed to provide an overview current situation anti-COVID-19 Japanese winter, considering company size. Methods was Internet-based nationwide cross-sectional study. Individuals who were registered as full-time workers invited participate survey. Data collected using online...
Mutants in the Big Blue transgenic mouse system show spontaneous clustered multiple mutations with unexpectedly high frequency, consistent chronocoordinate events. We tested prediction that seen within lacI mutation target sometimes occur context of spanning kilobases (mutation showers). Additional sequencing mutants was performed regions immediately flanking region (total 10.7 kb). Nineteen additional were found outside ("ectomutations") from 10 containing two or more mutations, whereas...
The clinical data of 183 patients with hepatitic cirrhosis and portal hypertensive splenomegaly complicated by peripheral cytopenia were retrospectively analyzed to investigate the causes cytopenia, as well proportion in these patients. All underwent splenectomy. Before operation, had one or more types (cumulative cytopenia: 390 patient-times). After splenectomy, blood counts 79.2% (309/390) returned normal, while 15.9% (62/390) they increased but failed reach normal levels, 4.9% (19/390)...
Background: The phylogenetic resolution within the Gloydius halys-intermedius Complex remains debatable due to following reasons: loci selection in previous studies varied between authors; limited dataset (1−5 mitochondrial or nuclear gene fragments); lack of sampling density; and nodal supports at specific nodes remain weak, specifically cognatus, G. halys, stejnegeri. Objectives: To revise taxonomic relationships Complex, we reconstructed molecular phylogeny performed species delimitation...
Aberrant activation of beta-catenin/TCF4 and STAT3 signaling in glioblastoma multiforme (GBM) has been reported. However, the molecular mechanisms related to this process are still poorly understood.Genome-wide screening binding characteristics transcription factors TCF4 GBM cells was performed by chromatin immunoprecipitation sequencing (ChIP-seq) assay. Hierarchical clustering used analyze association coregulated genes with The Cancer Genome Atlas (TCGA) subtypes (classical, mesenchymal,...
WHO2007 grading of diffuse gliomas in adults is well-established. However, IDH mutations make classification according to the edition controversial. Here, we characterized IDH-1R132H mut status a cohort 670 adult patients with different grades glioma. Patient characteristics, clinical data and prognoses were obtained from medical records. Patients younger had better outcomes than those without mutations. Differences age among astrocytomas eliminated after grouped based on status. was present...
This study aimed to explore the relationship between aggressiveness and immune cell infiltration in pituitary adenoma (PA) provide basis for immuno-targeting therapies.One hundred three patients with PA who underwent surgery at a single institution were retrospectively identified. The of macrophages T-lymphocytes was quantitatively assessed.The number CD68+ positively correlated Knosp (p = 0.003) MMP-9 expression grades 0.00). CD163+ differed among 0.022) 0.04). CD8+ tumor-infiltrating...
Objective Uniportal full‐endoscopic foraminotomy offers a promising alternative to conventional surgical methods for individuals afflicted by lumbar foraminal stenosis. This study aims evaluate the efficacy and clinical outcomes of uniportal in patients diagnosed with Methods A comprehensive retrospective analysis was conducted on who underwent our medical center, between January 2018 December 2019. The investigation encompassed demographic data key metrics such as visual analogue scale leg...
Glioblastoma multiforme (GBM) is one of the most malignant tumors. Depressive and anxiety disorders may co-exist with GBM. We investigated whether depression influenced outcomes The Patient Health Questionnaire 9-item (PHQ-9) Generalized Anxiety Disorder 7-item (GAD-7) scales were used to investigate mental condition GBM patients in our department, overall survival times these monitored. scores on both higher than healthy controls. For each scale, divided into high- low-score groups based...
Patients with cirrhosis and splenomegaly often have coagulation dysfunction which affects treatment prognosis. This study explores the status, grading, strategies of in patients liver splenomegaly.A retrospective cohort was conducted on clinical data consecutive treated at Hainan General Hospital, China, from January 2000 to December 2020. Starting research 2022.Among 1522 included into this study, 297 (19.5%) had normal results all five tests (prothrombin time, prothrombin activity,...
Abstract Background Human skin cutaneous melanoma is the most common and dangerous tumour, but its pathogenesis still unclear. Although some progress has been made in genetic research, no molecular indicators related to treatment prognosis of have found. In various diseases, dysregulation lncRNA common, role not fully elucidated. recent years, birth “competitive endogenous RNA” theory promoted our understanding lncRNAs. Methods To identify key lncRNAs melanoma, we reconstructed a global...
Abstract Background Due to the absence of specific symptoms and low survival rate, efficient biomarkers for hepatocellular carcinoma (HCC) diagnosis are urgently required. The purpose this study was evaluate diagnostic performance protein induced by vitamin K or antagonist‐II (PIVKA‐II) determine optimal cutoff values HBV infection‐related HCC. Methods We conducted a cross‐sectional, multi‐center in China ascertain value HCC patients context CHB‐ HBV‐related cirrhosis. receiver operating...
Early recurrence is the major cause of poor prognosis in hepatocellular carcinoma (HCC). Long non-coding RNAs (lncRNAs) are deeply involved HCC prognosis. In this study, we aimed to establish a prognostic lncRNA signature for early recurrence.The expression profile and corresponding clinical data were retrieved from total 299 patients TCGA database. LncRNA candidates correlated selected by differentially expressed gene (DEG), univariate Cox regression least absolute shrinkage selection...