The human ether à‐go‐go‐related gene ( HERG ) encodes a K + o channel that is believed to be the basis of delayed rectified current, I Kr , in cardiac muscle. We studied expressed Xenopus oocytes using two‐electrode and cut‐open oocyte clamp technique with [K ] 2 98 m . time course activation was measured an envelope tails protocol demonstrated heterologously current sigmoidal onset. At least three closed states were required reproduce sigmoid course. voltage dependence process its...

This study investigated the value of strain elastography (SE) in assessing extrathyroidal extension (ETE) papillary thyroid cancer (PTC). A total 277 PTC nodules from 245 patients were included. SE demonstrated higher consistency with pathology compared to US (Kappa value: 0.735 vs. 0.562, p = 0.000, respectively). also showed superior specificity (91.4% 74.1%, 0.000) and accuracy (87.7% 78.3%, 0.003) diagnosing ETE. The area under curve for was significantly than (0.865 0.798, 0.006). Age...

Hepatic arterioportal shunt (A-P shunt) is defined as the direct blood flow established between hepatic artery and portal venous system; it frequently observed in patients with hepatocellular carcinoma (HCC). Clinically, important to diagnose HCC associated A-P shunts, may impact treatment strategy of patients. In present study, we described imaging findings shunts discussed treatments such From findings, also potential cause shunts. Clinical data (n = 560), admitted hospital April 2012...

To evaluate the efficacy and safety of transcatheter arterial chemoembolization (TACE) in hepatocellular carcinoma (HCC) with regional lymph node metastases.Forty-eight patients HCC metastases were enrolled this study. The allocated into two groups: Group A (28 patients) underwent TACE for both intrahepatic tumors metastasis B (20 received only.The followed-up by contrast enhanced CT scan 6-8 weeks after treatment. In A, seven nine achieved complete partial response metastasis, respectively,...

Hashimoto's thyroiditis (TH) is a risk factor for the occurrence of papillary thyroid carcinoma (PTC), which considered to be most common type cancer. In recent years, prevalence PTC with TH has been increasing, but little known about genetic alteration in TH. This study analyzed mutation spectrum and signature somatic single nucleotide variants (SNV) 10 non-tumor tumor pair tissues using whole-exome sequencing. The ANK3 protein expression was evaluated by immunohistochemistry samples....

The prognosis of the patients with hepatocellular carcinoma (HCC) recurrence following curative hepatectomy is usually dismal. Whether preoperative serum C-reactive protein (CRP) can predict HCC in chronic HBV infection not clear. Total 232 were included this retrospective study. We investigated association between detailed CRP levels and early (≤ 2 year) late (> hepatectomy. After adjusting for potential confounders, we found a saturation effect 2.1 mg/dl existed (ER). incidence ER...

To compare the treatment outcomes of concurrent involved-field radiotherapy and XELOX (oxaliplatin capecitabine) versus chemotherapy alone in gastric adenocarcinoma patients with locoregional recurrence.From 2004 to 2008, 79 recurrent cancer after curative resection tumor were enrolled. Among them, 41 received (median dose 50 Gy) by a 3-dimensional conformal technique chemotherapy, 38 treated 130 mg/m, capecitabine 1000 twice daily, 3 wk each cycle).The radiochemotherapy group showed better...

This study aimed to evaluate the advantages of routine ultrasound (US), contrast-enhanced US (CEUS), and combination these 2 methods in diagnosing papillary thyroid carcinoma (PTC). We subjected 89 patients with calcified nodules conventional CEUS then retrospectively analyzed features single, solid PTC. On this basis, we evaluated ability US, CEUS, their diagnose In nodules, findings differed significantly from (P < 0.05). group, diagnostic sensitivity, specificity, accuracy were 87.5%,...

Background Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive lethal malignancy. An effective prognosis prediction model urgently needed for treatment optimization. Methods The differentially expressed unfolded protein response (UPR)‒related genes between pancreatic tumor and normal tissue were analyzed using the TCGA-PDAC dataset, these that overlapped with UPR‒related prognostic from E-MTAB-6134 dataset further analyzed. Univariate, LASSO multivariate Cox regression analyses...

Abstract Purpose Pancreatic ductal adenocarcinoma (PDAC) is one of the most malignant tumors. Endoplasmic reticulum stress (ERS) plays an essential role in PDAC progression. Here, we aim to identify ERS-related genes and build reliable risk models for diagnosis, prognosis immunotherapy response patients as well investigate potential mechanism. Methods We obtained cohorts with transcriptional profiles clinical data from ArrayExpress, The Cancer Genome Atlas (TCGA) Genotype-Tissue Expression...

// Hongxing Han 1, * , Fang Yuan Yuying Sun Jinfeng Liu 1 Shuguang Luo Fei Liang Nan Juan Long Xiao Zhao Fanhua Kong Yongzhi Xi Department of Immunology and National Center for Biomedicine Analysis, Beijing 307 Hospital Affiliated to Academy Military Medical Sciences, Beijing, China These authors have contributed equally this work Correspondence to: Xi, e-mail: xiyz@yahoo.com Kong, k.fanhua@yahoo.com Keywords: acute graft-versus-host disease, HLA alleles, three-dimensional structure...

Objective: To study the roles of miR-497 and PlexinA4 in progression laryngeal squamous cell carcinoma. Methods: The expressions fresh tumor specimens adjacent normal mucosa tissues as well lines carcinoma (LSCC) were detected with qRT-PCR immunohistochemistry. association clinicopathologic factors their prognostic values LSCC evaluated siRNA pcDNA3.1 (+ )/PlexinA4 plasmid transfected into measured by Transwell to evaluate effect on invasion LSCC. Results: was low expression LSCC, which...

Objective: To study the effects of miR-497 and CDK6 on growth laryngeal squamous cell carcinoma (LSCC). Methods: The expressions mRNA in fresh LSCC specimens, adjacent normal mucosa LSCC, lines were detected with quantitative real time polymerase chain reaction, pcDNA3.1(+) plasmids respectively transfected into cells, MTT assay clone formation performed to evaluate cells. Flow cytometry was employed for cycle analysis. SPSS17.0 software used analyze data. Results: highly expressed...

Colorectal cancer is one of the most common malignancies and third leading cause cancer-related mortality worldwide. Identifying KRAS, NRAS, BRAF mutations estimating MSI status closely related to individualized therapeutic judgment oncologic prognosis CRC patients. In this study, we introduce a cascaded network framework with an average voting ensemble strategy sequentially identify tumor regions predict gene & from whole-slide H&E images. Experiments on colorectal dataset indicate that...

We developed a novel tumor-immune index (TII) based on carcinoembryonic antigen levels, lymphocyte counts, and platelet explored its prognostic value in nonsmall cell lung cancer (NSCLC).The of the TII was evaluated retrospective study 205 patients with early NSCLC, who underwent resection whole year 2006, validated another group 228 enrolled next 2007. The optimal cut-off point for 578 × 10(-9), this used to stratify NSCLC into low (≤ 10(-9)) high (>578 groups. Univariate multivariate...

Based on the massive soil information in current quality grade evaluation, this paper constructed an intelligent classification approach of depending classical sampling techniques and disordered multiclassification Logistic regression model. As a case study to determine learning sample capacity under certain confidence level estimation accuracy, use c-means algorithm automatically extract simplified dataset from cultivated evaluation database for area, Long chuan county Guangdong province,...

Abstract Background : Recent research showed that probiotics treatment may reduce insulin resistance, regulate lipid metabolism, raise liver enzyme levels, and ameliorate inflammation in individuals with non-alcoholic fatty disease (NAFLD). However, the association between probiotic use hepatic steatosis people has not been identified. The purpose of this study was to investigate possible relationship exposure steatosis. Methods cross-sectional conducted among adults complete data on...

Abstract Background Recent research showed that probiotics treatment may reduce insulin resistance, regulate lipid metabolism, raise liver enzyme levels, and ameliorate inflammation in individuals with non-alcoholic fatty disease (NAFLD). However, the association between probiotic use hepatic steatosis people has not been identified. The purpose of this study was to investigate possible relationship exposure steatosis. Methods cross-sectional conducted among adults complete data on 2011–2016...