A5100688108- Liver Disease Diagnosis and Treatment
- Liver physiology and pathology
- Inflammasome and immune disorders
- Alcohol Consumption and Health Effects
- Hepatocellular Carcinoma Treatment and Prognosis
- Immune cells in cancer
- Liver Diseases and Immunity
- Radiomics and Machine Learning in Medical Imaging
- Acupuncture Treatment Research Studies
- Traditional Chinese Medicine Studies
- Anesthesia and Pain Management
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Pancreatitis Pathology and Treatment
- Immune Response and Inflammation
- Hepatitis B Virus Studies
- Pharmacological Effects of Natural Compounds
- Liver Disease and Transplantation
- Medical Research and Treatments
- NF-κB Signaling Pathways
- Pediatric Hepatobiliary Diseases and Treatments
- Urinary Bladder and Prostate Research
- Autophagy in Disease and Therapy
- Glaucoma and retinal disorders
- Reproductive Biology and Fertility
- Corneal surgery and disorders
Xiangya Hospital Central South University
2022-2025
Central South University
2022-2025
Sun Yat-sen University
2024-2025
Eighth Affiliated Hospital of Sun Yat-sen University
2024-2025
Chinese PLA General Hospital
2025
Chinese People's Liberation Army
2025
State Key Laboratory of Kidney Diseases
2025
Jilin University
2024
Jinan University
2024
UNSW Sydney
2024
Prediction of hepatocellular carcinoma (HCC) risk is an urgent unmet need in patients with nonalcoholic fatty liver disease (NAFLD). In cohorts 409 NAFLD from multiple global regions, we defined and validated hepatic transcriptome serum secretome signatures predictive long-term HCC NAFLD. A 133-gene signature, prognostic signature (PLS)–NAFLD, predicted incident over up to 15 years longitudinal observation. High-risk PLS-NAFLD was associated IDO1 + dendritic cells dysfunctional CD8 T...
Cholestatic liver fibrosis is caused by obstruction of the biliary tract and associated with early activation portal fibroblasts (PFs) that express Thy-1, fibulin 2, recently identified marker mesothelin (MSLN). Here, we have demonstrated activated PFs (aPFs) myofibroblasts play a critical role in pathogenesis induced bile duct ligation (BDL). Conditional ablation MSLN+ aPFs BDL-injured mice attenuated approximately 50%. Similar results were observed MSLN-deficient (Msln-/- mice) or...
Background & AimsAlthough there are associations among oxidative stress, reduced nicotinamide adenine dinucleotide phosphate oxidase (NOX) activation, and hepatocellular carcinoma (HCC) development, it is not clear how NOX contributes to hepatocarcinogenesis. We studied the functions of different proteins in mice after administration a liver carcinogen.MethodsFourteen-day-old Nox1–/– mice, Nox4–/– Nox1–/–Nox4–/– (double-knockout) wild-type (WT) C57BL/6 were given single intraperitoneal...
Abstract The role of JAK-3 in TLR-mediated innate immune responses is poorly understood, although the suppressive function JAK3 inhibition adaptive response has been well studied. In this study, we found that enhanced by differentially regulating pro- and anti- inflammatory cytokine production cells. Specifically, pharmacological inhibitors or specific small interfering RNA gene knockout resulted an increase proinflammatory cytokines while concurrently decreasing IL-10. Inhibition suppressed...
Toll-like receptor 4 (TLR4) signaling is activated through 2 adaptor proteins: MyD88 and TIR-domain containing adaptor-inducing interferon-β (TRIF). TLR4 are crucial in nonalcoholic steatohepatitis (NASH) fibrosis. However, the role of TRIF TLR4-mediated NASH fibrosis has been elusive. This study investigated differential roles hepatic steatosis inflammation/fibrosis.A choline-deficient amino acid defined (CDAA) diet was used for mouse model. On this diet, mice develop steatosis,...
Cytochrome P450 2E1 (CYP2E1) plays an important role in alcohol and toxin metabolism by catalyzing the conversion of substrates into more polar metabolites producing reactive oxygen species. Reactive species-induced oxidative stress promotes hepatocyte injury death, which turn induces inflammation, activation hepatic stellate cells, liver fibrosis. Here, we analyzed mice expressing only human CYP2E1 gene (hCYP2E1) to determine differences hCYP2E1 versus endogenous mouse Cyp2e1 function with...
Nutritional deficiencies remain significant public health issues in older populations globally. This study evaluates the burden, trends, and cross-country inequalities of four common nutritional (protein-energy malnutrition, iodine deficiency, vitamin A dietary iron deficiency) adults from 1990 to 2021. Age-standardised prevalence, disability-adjusted life years (DALYs), average annual percentage changes (AAPCs) these people aged ≥ 65 at global, regional, national levels were estimated...
To the Editor: Chronic postoperative pain (CPSP) is one of most common complications after surgery. Depending on risk factors, as many 5–58% patients experience chronic surgery[1]. The mechanism CPSP complex and uncertain; current understanding suggests that persistent peripheral inflammation nociceptive hypersensitivity play crucial roles. Lidocaine a type sodium channel blocker widely used clinically for local anesthesia antiarrhythmia. Recently, studies have demonstrated lidocaine has...
This study investigated the value of strain elastography (SE) in assessing extrathyroidal extension (ETE) papillary thyroid cancer (PTC). A total 277 PTC nodules from 245 patients were included. SE demonstrated higher consistency with pathology compared to US (Kappa value: 0.735 vs. 0.562, p = 0.000, respectively). also showed superior specificity (91.4% 74.1%, 0.000) and accuracy (87.7% 78.3%, 0.003) diagnosing ETE. The area under curve for was significantly than (0.865 0.798, 0.006). Age...
Abstract Increased endothelial permeability and a dysregulated inflammatory response play key roles in organ damage sepsis. The role of annexin A3 (ANXA3) regulating inflammation during sepsis is explored using ANXA3 knockout mice primary human umbilical vein cells (HUVECs). absence exacerbated outcomes, including increased mortality, lung injury, leukocyte infiltration, vascular permeability. highly expressed its loss results the formation cytoskeletal stress fibers decrease expression...
Developmental endothelial locus-1 (Del-1) is an cell-secreted protein that limits the recruitment of neutrophils by antagonizing interaction between LFA-1 integrin on and intercellular adhesion molecule (ICAM)-1 cells. Mice with genetic or age-associated Del-1 deficiency exhibit increased neutrophil infiltration in periodontium resulting inflammatory bone loss. Here we investigated additional novel mechanisms whereby could interfere inflammation. Treatment human cells did not affect...