A5069631565- Garlic and Onion Studies
- Alcohol Consumption and Health Effects
- Liver Disease Diagnosis and Treatment
- Pesticide Exposure and Toxicity
- Plant Molecular Biology Research
- Biological and pharmacological studies of plants
- Parkinson's Disease Mechanisms and Treatments
- Angiogenesis and VEGF in Cancer
- Plant Gene Expression Analysis
- Drug-Induced Hepatotoxicity and Protection
- Natural product bioactivities and synthesis
- Diet, Metabolism, and Disease
- Fibroblast Growth Factor Research
- Plant and animal studies
- Gut microbiota and health
- Mycobacterium research and diagnosis
- Microbial Metabolic Engineering and Bioproduction
- Mitochondrial Function and Pathology
- Cell death mechanisms and regulation
- Skin and Cellular Biology Research
- Botanical Research and Applications
- Healthcare and Venom Research
- Genomics, phytochemicals, and oxidative stress
- Biofuel production and bioconversion
- Tea Polyphenols and Effects
Fujian Agriculture and Forestry University
2022-2024
Shandong University
2013-2024
Harbin Medical University
2008-2023
First Affiliated Hospital of Harbin Medical University
2009-2023
Huanghe Science and Technology College
2017-2022
Hainan University
2021-2022
Dalian Medical University
2011-2021
Xingtai Medical College
2019-2021
Xingtai University
2019-2021
University of California, San Diego
2018-2021
Ulcerative colitis (UC) has been identified as one of the inflammatory diseases. Intestinal mucosal barrier function and microflora play major roles in UC. Modified-chitosan products have consumed effective safe drugs to treat The present work aimed investigate effect chitosan (CS) on intestinal dextran sulfate sodium (DSS)-induced UC mice explore underlying mechanisms. KM (Kunming) received water/CS (250, 150 mg/kg) for 5 days, then 3% DSS days induce Subsequently, CS was administered daily...
To investigate the protective effects and possible mechanisms of garlic oil (GO) against N-nitrosodiethylamine (NDEA)-induced hepatocarcinoma in rats, Wistar rats were gavaged with GO (20 or 40 mg/kg) for 1 week, then NDEA (10 next 20 weeks.The changes morphology, histology, biochemical indices serum, DNA oxidative damage liver examined to assess effects.Lipid peroxidation (LPO), antioxidant defense system, apoptosis-related proteins measured potential mechanisms.At end study (21 weeks),...
Protein kinase B (PKB/Akt) plays important roles in the regulation of lipid homeostasis, and impairment Akt activity has been demonstrated to be involved development non-alcoholic fatty liver disease (NAFLD). Previous studies suggest that cytochrome P4502E1 (CYP2E1) causal pathogenesis alcoholic (AFL). We hypothesized might impaired due CYP2E1-induced oxidative stress chronic ethanol-induced hepatic steatosis. In this study, we found steatosis was accompanied with reduced phosphorylation at...
Alzheimer’s disease (AD) is a chronic neurodegenerative which contributes to memory loss and cognitive decline in the elderly. Fucoidan, extracted from brown algae, complex sulfated polysaccharide potential bioactive compound. In this study, we investigated whether fucoidan protects PC12 cells apoptosis induced by combination of beta-amyloid 25–35 (Aβ25–35) d-galactose (d-Gal), improves learning impairment AD model mice. The results indicated that could inhibit release cytochrome c...
Apostasia shenzhenica belongs to the subfamily Apostasioideae and is a primitive group located at base of Orchidaceae phylogenetic tree. However, A. mitochondrial genome (mitogenome) still unexplored, relationships between monocots mitogenomes remain unexplored. In this study, we discussed genetic diversity within its monocotyledon mitogenome. We sequenced assembled complete mitogenome shenzhenica, resulting in circular draft 672,872 bp, with an average read coverage 122× GC content 44.4%....
The potential obesogenic roles of di(2-ethylhexyl) phthalate (DEHP) have attracted great attention. current study aimed to evaluate the combined effects chronic low-dose DEHP (0.05 mg/kg BW) and a high-fat diet (HFD) on obesity in female mice explore underlying mechanisms. We found that challenge for 29 weeks increased fat accumulation both CD- HFD-fed significantly accelerated weight gain without affecting food intake mice. exposure reduced energy metabolism, down-regulated uncoupling...
Background & AimsAlthough there are associations among oxidative stress, reduced nicotinamide adenine dinucleotide phosphate oxidase (NOX) activation, and hepatocellular carcinoma (HCC) development, it is not clear how NOX contributes to hepatocarcinogenesis. We studied the functions of different proteins in mice after administration a liver carcinogen.MethodsFourteen-day-old Nox1–/– mice, Nox4–/– Nox1–/–Nox4–/– (double-knockout) wild-type (WT) C57BL/6 were given single intraperitoneal...
Probiotic bacteria are known to exert a wide range of beneficial effects on their animal hosts. Therefore, the present study explored effect supernatants obtained from Lactobacillus delbrueckii fermentation (LBF) colon cancer. The results indicated that proliferation LBF solution-treated cancer SW620 cells was arrested and accumulated in G1 phase concentration-dependent manner. solution efficiently induced apoptosis through intrinsic caspase 3-depedent pathway, with corresponding decreased...
Drought stress is a bottleneck factor for plant growth and development, especially in epiphytic orchids that absorb moisture mainly from the air. Recent studies have suggested there are complex transcriptional regulatory networks related to drought Dendrobium sinense. In this study, transcription metabolite alterations involved response D. sinense were investigated through RNA-seq metabolomics. A total of 856 metabolites identified stressed control samples, with 391 showing significant...
Abstract Multiple sclerosis (MS) is a highly disabling demyelinating disease, which mainly affects young adults and difficult to cure. Activated microglia may be involved in the process of neuronal cell damage release inflammatory cytokines injure neurons. Rapamycin (RAPA), an immunosuppressant, can induce autophagy delay disease. As inhibitor NLRP3, MCC950 (CP‐456773) regulate activation inflammasome. An experimental autoimmune encephalomyelitis model, disease model MS, was established...