A5042640098- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Alcohol Consumption and Health Effects
- Liver Disease Diagnosis and Treatment
- Mycobacterium research and diagnosis
- Immune Cell Function and Interaction
- Iron oxide chemistry and applications
- Characterization and Applications of Magnetic Nanoparticles
- Gut microbiota and health
- Quantum Dots Synthesis And Properties
- Biosensors and Analytical Detection
- Garlic and Onion Studies
- Magnetic Properties and Synthesis of Ferrites
- Tuberculosis Research and Epidemiology
- Cancer Research and Treatments
- Heme Oxygenase-1 and Carbon Monoxide
- Electrochemical sensors and biosensors
- Polyamine Metabolism and Applications
- Advanced Nanomaterials in Catalysis
- Graphene and Nanomaterials Applications
- Photodynamic Therapy Research Studies
First Affiliated Hospital Zhejiang University
2024-2025
First Affiliated Hospital of Jinan University
2022-2024
Jilin University
2017-2023
Renji Hospital
2017-2023
Shanghai Jiao Tong University
2011-2023
State Key Laboratory of Oncogene and Related Genes
2016-2023
Shanghai Cancer Institute
2016-2023
Shanghai East Hospital
2014-2023
Nanchang Institute of Technology
2023
Qilu Hospital of Shandong University
2012-2022
Long non-coding RNAs (lncRNAs) contribute to colorectal cancer (CRC). However, the role of lncRNAs in CRC metabolism, especially glucose metabolism remains largely unknown. In this study, we identify a lncRNA, GLCC1, which is significantly upregulated under starvation cells, supporting cell survival and proliferation by enhancing glycolysis. Mechanistically, GLCC1 stabilizes c-Myc transcriptional factor from ubiquitination direct interaction with HSP90 chaperon further specifies modification...
Objective Microbiota disorder promotes chronic inflammation and carcinogenesis. High glycolysis is associated with poor prognosis in patients colorectal cancer (CRC). However, the potential correlation between gut microbiota glucose metabolism unknown CRC. Design 18 F-FDG ( F-fluorodeoxyglucose) PET (positron emission tomography)/CT image scanning data PCR analysis were performed to measure metabolic alterations 33 Multiple models, Seahorse assay established assess role of long non-coding...
The synergistic adsorption of heavy metal ions and humic acid can be very challenging. This is largely because their competitive onto most adsorbent materials. Hierarchically structured composites containing polyethylenimine-modified magnetic mesoporous silica graphene oxide (MMSP-GO) were here prepared to address this. Magnetic microspheres synthesized functionalized with PEI molecules, providing many amine groups for chemical conjugation the carboxyl on GO sheets enhanced affinity between...
The long noncoding RNA (lncRNA) colon cancer–associated transcript–1 (CCAT1) has been reported to play a vital role in the development of cancer. Although link between inflammation and cancer initiation is well established, whether CCAT1 involved promotes inflammatory bowel disease (IBD) malignancy remains undetermined. We aimed investigate expression IBD effect overexpression on intestinal epithelial barrier function. relationship inflammation-related pathway was analyzed both colorectal...
Abstract Long non-coding RNAs (lncRNAs) play key roles in colorectal carcinogenesis. Here, we aimed to identify the risk SNP-induced lncRNAs and investigate their First, identified rs6695584 as causative SNP 1q41 locus. The A>G mutation of created a protein-binding motif BATF, altered enhancer activity, subsequently activated lncSLCC1 expression. Further validation two independent CRC cohorts confirmed upregulation tissues, revealed that increased expression was associated with poor...
Objective: The E3 ubiquitin ligase RNF6 (RING-finger protein 6) plays a crucial role in carcinogenesis. However, the copy number and expression of were rarely reported colorectal cancer. We aimed to explore mechanical, biological, clinical cancer initiation progression.Design: analyzed from Tumorscape Cancer Genome Atlas (TCGA) datasets. Gene expressions examined by real-time PCR, Western blot, immunohistochemical staining. profiling studies performed identify pivotal genes regulated RNF6....
A one-pot colloidal reaction strategy was developed to synthesize asymmetric magnetic composite particles (AMCPs) with high anisotropy and content. The asymmetricity established by having two portions of the particle composed both polystyrene silica, among which latter conjugated magnetite nanoparticles. Phase separation found be critical in developing structure between inorganic polymer components during miniemulsion polymerization sol–gel reaction. Morphological control achieved a...
Biodegradable polymer poly (dl-lactide) (PDLLA) has been used as drug coating material for drug-eluting stents due to its excellent biocompatibility and sustained release ability. However, the uniform thin layer eluting on a stent not only inhibits blood vessel's smooth muscle cell overgrowth but also delay endotheliation process which is often associated with occurrence of acute thrombosis. Therefore, in this study, we developed novel method using PDLLA nanoparticles (NPs) overcome issue....