A5100728334- Urticaria and Related Conditions
- Mast cells and histamine
- Autoimmune Bullous Skin Diseases
- Allergic Rhinitis and Sensitization
- Skin Protection and Aging
- Photodynamic Therapy Research Studies
- Acute Kidney Injury Research
- Acne and Rosacea Treatments and Effects
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- MRI in cancer diagnosis
- Herpesvirus Infections and Treatments
- Intensive Care Unit Cognitive Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Tissue Engineering and Regenerative Medicine
- Cytomegalovirus and herpesvirus research
- Extracellular vesicles in disease
- Dermatology and Skin Diseases
- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Viral gastroenteritis research and epidemiology
- Renal and Vascular Pathologies
- Contact Dermatitis and Allergies
- Biomarkers in Disease Mechanisms
- Dermatological and Skeletal Disorders
- Neuroendocrine Tumor Research Advances
Hangzhou Medical College
2022-2025
Zhejiang Provincial People's Hospital
2022-2025
Hunan University
2023-2024
Hebei Agricultural University
2024
Zhongshan Hospital of Xiamen University
2024
Mayo Clinic
2012-2023
First Affiliated Hospital of Jinan University
2023
Shandong Center for Disease Control and Prevention
2023
Kunming University of Science and Technology
2022
Huashan Hospital
2008-2022
Early detection of esophageal squamous cell carcinoma (ESCC) will facilitate curative treatment. We aimed to establish a microRNA (miRNA) signature derived from salivary extracellular vesicles and particles (EVPs) for early ESCC prognostication.Salivary EVP miRNA expression was profiled in pilot cohort (n = 54) using microarray. Area under the receiver operator characteristic curve (AUROC) least absolute shrinkage selector operation regression analyses were used prioritize miRNAs that...
Sepsis-associated encephalopathy (SAE) is a diffuse brain dysfunction caused by many pathological events, including neuroinflammation and oxidative stress damage. Increasing evidence suggests that parvalbumin (PV) interneurons play key role in the cognitive process, whereas of these has been implicated number major psychiatric disorders. Here, we aimed to investigate whether enhanced inflammation stress-mediated PV interneuron phenotype loss plays sepsis-induced impairments.Male C57BL/6 mice...
Background Emerging evidence indicates that the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) axis plays a pivotal role in intrinsic antitumor immunity. Previous studies demonstrate conventional chemotherapy agent, teniposide, effectively promotes therapeutic efficacy programmed cell death protein-1 antibody (PD-1 Ab) through robust cGAS-STING activation. Unfortunately, cGAS expression tumor cells is reported to be severely suppressed by hypoxic status solid tumor....
The effect of micronutrients on thyroid cancer has been studied in observational studies, however, the cause relationships not yet determined. Thyroid was subject a Mendelian randomization (MR) analysis micronutrients. Aimed to determine whether micronutrient intake causal impact chance developing cancer. We used with two samples. Our circulation levels Cu, Ir, Zn, Ca, VD, and VC were reflected by genetic variations reported from GWAS individuals European ancestry. For outcome Sensitivity...
ABSTRACT Background In recent decades, our understanding of the pathogenesis and pathophysiology skin photoaging has improved considerably, thereby enhancing preventive management strategies. The bibliometric analysis demonstrates chronological trends publications, highlighting most influential studies related to photoaging. Objective This study aims identify analyze top 100 most‐cited articles offer information. Methods Web Science database was searched obtain publications on Information...
Objectives: To determine the safety and efficacy of photodynamic therapy (PDT) with topical application 20% wt/vol aminolevulinic acid hydrochloride (ALA) in treatment condylomata acuminata (CA). Study design: Patients CA were randomly allocated into ALA‐PDT group CO 2 laser an allocation ratio 3 : 1. The was repeated weekly if necessary, but no more than times. primary endpoint wart clearance rate 1 week after last treatment. recurrence evaluated at weeks 4, 8 12 ended. clinical response to...
Zika virus (ZIKV) is a newly emerging flavivirus that broadly exhibits in various bodily tissues and fluids, especially the brain, ZIKV infection often causes microcephaly. Previous studies have been reported can infect renal cells be detected urine samples of infected individuals. However, whether diseases its pathogenic mechanisms remains unknown. Here, we identified resulted acute kidney injury (AKI) both newborn adult mouse models by increasing levels AKI-related biomarkers [e.g., serum...
Tumor necrosis factor-α-induced gene/protein (TSG)-6 regulates the immunomodulatory properties of MSCs, but its ability to protect ischemic kidney is unknown. In pigs with renal artery stenosis, we show that MSC delivery increased vein TSG-6, decreased inflammatory macrophages, and improved function. vitro, TSG-6 macrophages tubular cell injury. Therefore, released from MSCs may decrease injury, which associated regulating macrophage function phenotype.
Tembusu virus (TMUV) is a member of the genus Flavivirus in family Flaviviridae. Currently, TMUV was classified into 4 distinct clusters, with cluster 2 strains widely distributed duck and goose populations Asia, causing significant economic losses to producing industries. In this study, novel strain TMUV/goose/CHN/2019/HNU-NX2 (HNU-NX2-2019) isolated characterized from geese ovaritis Hunan province, China. Phylogenetic analyses genome E gene indicated present could be grouped newly defined...
The rodent model of folic acid (FA)-induced acute kidney injury (AKI) provides a useful for studying human AKI, but little is known about longitudinal changes in renal hemodynamics and evolution fibrosis vivo. In this work, we aimed to longitudinally assess structural functional using multiparametric magnetic resonance imaging (MRI). Ten adult mice were injected with FA, after which MRI was used measure volume, hypoxia index R 2 *, magnetization transfer ratio (MTR), perfusion, T 1 ,...
Photoallergic contact dermatitis (PACD) is a hypersensitivity reaction that occurs when previously photosensitized exogenous agent comes into with UV radiation. The best method for testing PACD photopatch (PPT).The primary objective of the study was to determine frequency 20 different photoallergens in common usage China during 10-year period.All patients (n = 6153) who had PPTs done between 2005 and 2014 at Department Dermatology Huashan Hospital, Fudan University, were included.A total...
Renovascular hypertension (RVH) can induce cardiac damage that is reversible using adipose tissue-derived mesenchymal stromal/stem cells (A-MSCs). However, A-MSCs isolated from patients with obesity are less effective than lean-A-MSC in blunting hypertensive cardiomyopathy mice RVH. We tested the hypothesis this impairment extends to their obese A-MSC-extracellular vesicles (EVs) progeny. MSCs were harvested subcutaneous fat of and lean human subjects, EVs collected injected into aorta 2 wk...
Uveitis is a serious intra-ocular inflammatory disease that can lead to visual impairment even blindness worldwide. Notch signaling regulate the differentiation of naive CD4+ T cells, influencing development uveitis. DNA methylation closely related autoimmune diseases. In this study, we measured Notch1 level, determined and methylases mRNA expression evaluated ratio helper type 17 regulatory cell (Th17/Treg ) in peripheral blood mononuclear cells (PBMCs) from uveitis patients normal control...
Abstract Background In 2015, a Chinese expert consensus on photopatch testing (PPT) was established, based European methodology. Objectives To update current information the prevalence of photoallergic contact dermatitis (PACD) to 20 photoallergens and their clinical relevance in context. Methods A retrospective analysis 2372 patients who performed PPT tertiary referral center China between 2015 2019 completed. total 1208 PACD reactions were observed 897 (37.8%) patients, 413 or past...
Objective To evaluate the efficacy and safety of Qingpeng ointment in treatment eczema.Methods A multi-center,randomized,double-blind placebo-controlled clinical trial was conducted.A total 246 patients with eczema were randomly assigned a ratio 2∶1 to group control topically apply placebo respectively twice daily for 3 weeks.Total symptom scores calculated at baseline,on week 1,2 during according individual pruritus,lesions including erythema,papules,papulovesicles or...
The root system plays a vital role in plants' ability to absorb water and nutrients. In situ research offers an intuitive approach exploring phenotypes their dynamics. Deep-learning-based segmentation methods have gained popularity, but they require large labeled datasets for training. This paper presents expansion method using improved CycleGAN generator. addition, spatial-coordinate-based target background separation is proposed, which solves the issue of pixel variations caused by...