A5043681590- Advanced MRI Techniques and Applications
- Advanced NMR Techniques and Applications
- NMR spectroscopy and applications
- Protein Structure and Dynamics
- Electron Spin Resonance Studies
- Molecular spectroscopy and chirality
- Sesquiterpenes and Asteraceae Studies
- Metabolomics and Mass Spectrometry Studies
- Mitochondrial Function and Pathology
- Glioma Diagnosis and Treatment
- MRI in cancer diagnosis
- Phytochemistry and Biological Activities
- Hedgehog Signaling Pathway Studies
- Enzyme Structure and Function
- Natural product bioactivities and synthesis
- RNA and protein synthesis mechanisms
- Multiple Sclerosis Research Studies
- DNA and Nucleic Acid Chemistry
- Traditional and Medicinal Uses of Annonaceae
- Spectroscopy and Quantum Chemical Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Genetic and Kidney Cyst Diseases
- Cancer, Hypoxia, and Metabolism
- Plant Toxicity and Pharmacological Properties
- Epigenetics and DNA Methylation
WinnMed
1997-2025
Mayo Clinic
2014-2024
Mayo Clinic in Florida
1993-2022
Mayo Clinic in Arizona
2000-2022
Joint Center for Structural Genomics
2019
Resonance Research (United States)
2017
University of Belgrade
1985-2007
University of Wisconsin–Madison
1988-2006
University of Rochester
1992-2004
Institute for Plant Protection and Environment
2003
Abstract Two-dimensional N.M.R. spectroscopy is applied to the elucidation of cross relaxation pathways in liquids. The theory underlying two dimensional studies and transient nuclear Overhauser effects developed. influence correlation time molecular random process investigated. It found that limit short times (extreme narrowing limit) weak negative cross-peaks are observed. However, for long (spin diffusion strong positive can be obtained. technique appears particularly promising study...
Purpose To test the utility of magnetization transfer imaging in detecting and monitoring progression renal fibrosis mice with unilateral artery stenosis. Materials Methods This prospective study was approved by Institutional Animal Care Use Committee. Renal stenosis surgery (n = 10) or sham 5) performed, stenotic contralateral kidneys were studied longitudinally vivo at baseline 2, 4, 6 weeks after surgery. After a 16.4-T magnetic resonance examination, ratio measured as an index (guided...
Abstract Alzheimer’s Disease (AD) is a devastating neurodegenerative disorder without cure. Here we show that mitochondrial respiratory chain complex I an important small molecule druggable target in AD. Partial inhibition of triggers the AMP-activated protein kinase-dependent signaling network leading to neuroprotection symptomatic APP/PS1 female mice, translational model Treatment mice with inhibitor improved energy homeostasis, synaptic activity, long-term potentiation, dendritic spine...
The human monoclonal antibody rHIgM22 enhances remyelination following spinal cord demyelination in a virus-induced murine model of multiple sclerosis. Using three-dimensional T2-weighted vivo magnetic resonance imaging (MRI), we have therefore assessed the extent demyelination, before and after 5 weeks treatment with rHIgM22, to determine whether enhanced can be detected by MRI. A significant decrease was seen T2 high signal lesion volume treatment. Histologic examination tissue reveals...
1H NMR spectroscopy has enabled the quantitative profiling of metabolites in various biofluids, emerging as a possible diagnostic tool for metabolic disorders and other diseases. To boost signal-to-noise ratio detect proton resonances near water signal, current experiments require solvent suppression schemes (e.g., presaturation, jump-and-return, WATERGATE, excitation sculpting, etc.). Unfortunately, these techniques affect assessment analytes containing exchangeable protons. address this...
This protocol is for the synthesis of cis-(N-(pyridin-4-ylmethyl)-2-(3-(m-tolyloxy)cyclohexyl)propan-1-amine) (c458)
This protocol is for LC-MS/MS quantification of C458. has been used to detect tissue concentrations
Abstract Despite recent approval of monoclonal antibodies that reduce amyloid (Aβ) accumulation, the development disease-modifying strategies targeting underlying mechanisms Alzheimer’s disease (AD) is urgently needed. We demonstrate mitochondrial complex I (mtCI) represents a druggable target, where its weak inhibition activates neuroprotective signaling, benefiting AD mouse models with Aβ and p-Tau pathologies. Rational design structure‒activity relationship studies yielded novel mtCI...
Four flavones (1−4) and nine sesquiterpene lactones (5−13), one of them (5) a new compound, were isolated from the aerial parts Achillea atrata L. subsp. multifida. Although crude extract demonstrated in vitro inhibitory activity against Candida albicans Bacillus subtilis, all active B. subtilis. Flavones 1, 2, 3 also C. albicans, while 1 exhibited E. coli, as well. None tested (7, 9, 12, 13) showed any antimicrobial activity.
We developed a novel MRI technique to image immune cell location and homing in vivo the central nervous system (CNS). Superparamagnetic antibodies specific for surface markers allowed imaging of CD4+ T cells, CD8+ Mac1+ cells CNS mice infected with Theiler's murine encephalomyelitis virus (TMEV) experimental autoimmune (EAE). have excellent T2, T2*, good T1 relaxation properties, which makes them ideal contrast materials. Immunohistochemistry corresponding sections confirmed specificity...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCarbon-13 exchange maps for the elucidation of chemical networksY. Huang, S. Macura, and R. ErnstCite this: J. Am. Chem. Soc. 1981, 103, 18, 5327–5333Publication Date (Print):September 1, 1981Publication History Published online1 May 2002Published inissue 1 September 1981https://pubs.acs.org/doi/10.1021/ja00408a008https://doi.org/10.1021/ja00408a008research-articleACS PublicationsRequest reuse permissionsArticle Views150Altmetric-Citations67LEARN...
Glioblastoma (GBM) is uniformly fatal with a 1-year median survival, despite best available treatment, including radiotherapy (RT). Impacts of prior RT on tumor recurrence are poorly understood but may increase aggressiveness. Metabolic changes have been investigated in radiation-induced brain injury; however, the tumor-promoting effect following radiation lacking. Since vital to GBM management, we quantified effects patient-derived intracranial xenografts and characterized metabolic...
Rapid exchange of high energy carrying molecules between intracellular compartments is essential in sustaining cellular energetic homeostasis. Adenylate kinase (AK)-catalyzed transfer adenine nucleotide β- and γ-phosphoryls has been implicated communication metabolism. To demonstrate the significance this reaction cardiac energetics, phosphotransfer dynamics were determined by [<sup>18</sup>O]phosphoryl oxygen analysis using<sup>31</sup>P NMR mass spectrometry. In hearts with a null mutation...