Abstract The aim of this study is to explore the feasibility using machine learning (ML) technology predict postoperative recurrence risk among stage IV colorectal cancer patients. Four basic ML algorithms were used for prediction—logistic regression, decision tree, GradientBoosting and lightGBM. research samples randomly divided into a training group testing at ratio 8:2. 999 patients with 4 included in study. In group, model’s AUC value was highest, 0.881. Logistic lowest, 0.734. model had...

Inflammatory depression is closely related to neuroinflammation. However, current anti-inflammatory drugs have low permeability cross blood-brain barrier with difficulties reaching the central nervous system provide therapeutic effectiveness. To overcome this limitation, nano-based drug delivery technology was used synthesize melanin-like polydopamine nanoparticles (PDA NPs) (~ 250 nm) which can barrier. Importantly, PDA NPs abundant phenolic hydroxyl groups function as excellent free...

Sepsis-associated encephalopathy (SAE) is a diffuse brain dysfunction caused by many pathological events, including neuroinflammation and oxidative stress damage. Increasing evidence suggests that parvalbumin (PV) interneurons play key role in the cognitive process, whereas of these has been implicated number major psychiatric disorders. Here, we aimed to investigate whether enhanced inflammation stress-mediated PV interneuron phenotype loss plays sepsis-induced impairments.Male C57BL/6 mice...

Abstract Background Preclinical studies have indicated that the ketamine metabolite ( 2R,6R )-hydroxynorketamine (HNK) is a rapid-acting antidepressant drug with limited dissociation properties and low abuse potential. However, its effects molecular mechanisms remain unclear. In this work, we examined involvement of brain-derived neurotrophic factor (BDNF), tropomyosin receptor kinase B (TrkB) Narp in antidepressant-like actions )-HNK chronic restraint stress (CRS) mouse model. Methods...

Abstract Background Maladaptation of the HPA (hypothalamic–pituitary–adrenal) axis plays an important role in depression-like behaviour, but specific molecular mechanisms are unknown. Here, we determined roles CRHR1 (corticotrophin releasing hormone receptor 1) and nectin3 LPS (lipopolysaccharide)-induced behaviour mice. Methods C57BL/6 male mice were intraperitoneally injected with (0.83 g/kg), open field, novelty-suppressed feeding, forced swimming, tail suspension tests performed after...

A combination of antidepressant drugs and psychotherapy exhibits more promising efficacy in treating fear disorders than either treatment alone, but underlying mechanisms such treatments remain largely unknown. Here we investigated the role DNA methylation brain-derived neurotrophic factor (Bdnf) gene therapeutic effects ketamine with extinction training a mouse model post-traumatic stress disorder (PTSD) induced by inescapable electric foot shocks (IFS). Male mice received for 22...

Sevoflurane administered to neonatal rats induces neurobehavioral abnormalities and epigenetic reprogramming of their germ cells; the latter can pass adverse effects sevoflurane future offspring. As cells are susceptible by environmental factors across lifespan, authors hypothesized that adult could induce in offspring, but not exposed themselves.Sprague-Dawley were anesthetized with 2.1% for 3 h every other day between postnatal days 56 60. Twenty-five later, nonexposed controls mated...

Noniridescent structural colors, by virtue of their pigment-like features and simple preparation techniques, have pivotal roles in color-related applications. However, because the wide bandwidth resulting from coherent scattering, noniridescent colors lack angle-altered color feature, which plays a critical role colored identification color. Therefore, developing novel strategy for security applications remains challenge. Inspired Diphylleia grayi, we developed thickness-controlled...

Children of parents with traumatic brain injury (TBI) are more likely to develop psychiatric disorders. This association is usually attributed TBI-induced changes in parents' personality and families' social environment. We tested the hypothesis that offspring young adult male rats TBI neurodevelopmental abnormalities absence direct contact sires. Male Sprague-Dawley (F0 generation) group underwent moderate via a midline fluid percussion involved craniectomy under sevoflurane (SEVO)...

Background The authors tested the hypothesis that effects of traumatic brain injury, surgery, and sevoflurane interact to induce neurobehavioral abnormalities in adult male rats their offspring (an animal model intergenerational perioperative neurocognitive disorder). Methods Sprague-Dawley (assigned generation F0) underwent a injury on postnatal day 60 involved craniectomy (surgery) under 3% for 40 min followed by 2.1% 3 h days 62, 64, 66 (injury group). surgery group had without whereas...

To use machine learning algorithms to predict the death outcomes of patients with triple-negative breast cancer, 5 years after discharge.1570 stage I-III cancer receiving treatment from Sun Yat-sen Memorial Hospital were analyzed. Machine was used discharge.The results showed that platelets, LMR (lymphocyte-to-monocyte ratio), age, PLR (the platelet-to-lymphocyte ratio) and white blood cell counts accounted for a significant weight in 5-year prognosis patients. The model prediction indicated...

Testosterone (T), acting through its derivative 17β-estradiol (E2), regulates the brain's sexual differentiation in rodents during perinatal sensitive period, which mirrors window of vulnerability to adverse effects general anesthetics. The mechanisms anesthesia's are poorly understood. We investigated whether sevoflurane alters T and E2 levels they contribute sevoflurane's acute postnatal day 5 Sprague-Dawley rats. rats underwent electroencephalography recordings for 2 h baseline activity...

Background: Children exposed to general anesthesia early in life may develop significant neurodevelopmental abnormalities. Establishing safer pediatric is impeded by a lack of understanding the initial mediating mechanisms such effects. Here, we tested roles sex steroid 17β-estradiol (E2) and excitatory GABA type A receptor signaling, whose specific developmental effects rodents occur during age period increased vulnerability anesthetics. Methods: Sprague-Dawley rats were pretreated with...