A5101847175- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Renal and Vascular Pathologies
- Tissue Engineering and Regenerative Medicine
- Cardiovascular Disease and Adiposity
- Intracerebral and Subarachnoid Hemorrhage Research
- Stroke Rehabilitation and Recovery
- Cancer Research and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Biosimilars and Bioanalytical Methods
- Venous Thromboembolism Diagnosis and Management
- MRI in cancer diagnosis
- Mesenchymal stem cell research
- Traditional Chinese Medicine Studies
- Advanced MRI Techniques and Applications
- Wireless Power Transfer Systems
- Psoriasis: Treatment and Pathogenesis
- Medical Research and Treatments
- Hormonal Regulation and Hypertension
- Cardiovascular Health and Disease Prevention
- Healthcare and Venom Research
- Heme Oxygenase-1 and Carbon Monoxide
- Ultrasound and Hyperthermia Applications
- Extracellular vesicles in disease
- 3D Printing in Biomedical Research
Hua Medicine (China)
2025
Nantong University
2019-2023
Second Affiliated Hospital of Nantong University
2019-2023
Mayo Clinic
2017-2023
Affiliated Hospital of Nantong University
2019-2023
National Health Insurance Fund
2017
National Institutes of Health
2017
XinHua Hospital
2003
Abstract To test the hypothesis that intrinsic renal scattered tubular cells (STC-like cells) contribute to repairing injured epithelial (TEC) by releasing extracellular vesicle (EV). EV released from primary cultured pig STC-like were confirmed electron microscopy. Antimycin-A (AMA)-induced proximal TEC (PK1 co-cultured with cells, cells-derived EV, or EV-free conditioned-medium for 3 days. Cellular injury, oxidative stress and mitochondrial function assessed. Transfer of mitochondria was...
Renal fibrosis is a useful biomarker for diagnosis and evaluation of therapeutic interventions renal diseases but often requires invasive testing. Magnetization transfer magnetic resonance imaging (MT-MRI), which evaluates the presence macromolecules, offers noninvasive tool to probe in murine artery stenosis (RAS) at 16.4 T. In this study, we aimed identify appropriate parameters collagen detection 3.0 T MRI test utility MT-MRI measuring swine model atherosclerotic RAS (ARAS).To select...
e14504 Background: HB0036 is a bispecific IgG1 antibody targeting both human programmed death ligand 1 (PD-L1) and the T cell immunoreceptor with immunoglobulin ITIM domain (TIGIT). Here we report initial results from first-in study ofHB0036 in patients advanced malignancies. Methods: This first-in-human, phase I/II, multicenter, dose escalation expansion of administered intravenously to adult pts resistant/ refractory or metastatic solid tumors who had failed standard therapies. Monotherapy...
Renovascular hypertension (RVH) can induce cardiac damage that is reversible using adipose tissue-derived mesenchymal stromal/stem cells (A-MSCs). However, A-MSCs isolated from patients with obesity are less effective than lean-A-MSC in blunting hypertensive cardiomyopathy mice RVH. We tested the hypothesis this impairment extends to their obese A-MSC-extracellular vesicles (EVs) progeny. MSCs were harvested subcutaneous fat of and lean human subjects, EVs collected injected into aorta 2 wk...
Background: To investigate the value of fluid-attenuated inversion recovery (FLAIR) Vascular Hyperintensity (FVH) in predicting early neurological deterioration (END) and short-term prognosis acute ischemic stroke (AIS) patients who beyond time window for recanalization therapy. Methods: We retrospectively analyzed AIS from 24 to 72 hours after symptom onset, received dual antiplatelet therapy (DAPT). The were divided into END no (NEND) group according change National Institutes Health...
Abstract Background The aim of this study was to investigate the association between insulin resistance (IR) and vascular cognitive impairment (VCI) in patients with cerebral small vessel disease (CSVD). Methods A total 275 CSVD were enrolled retrospective case–control study. homeostatic model assessment (HOMA‐IR) used measure index resistance. Cognitive function assessed using Montreal Assessment (MoCA). Spearman's correlation coefficient evaluate HOMA‐IR MoCA score. variance inflation...
Autophagy eliminates excessive nutrients and maintains homeostasis. Obesity metabolic syndrome (MetS) dysregulate autophagy, possibly partly due to mitochondria injury inflammation. Elamipretide (ELAM) improves mitochondrial function. We hypothesized that MetS blunts kidney which ELAM would restore. Domestic pigs were fed a control or MetS-inducing diet for 16 weeks. During the 4 last weeks, received subcutaneous injections of (0.1 mg/kg/day, + ELAM) vehicle (MetS), kidneys then harvested...
2589 Background: HB0025 is a recombinant humanized anti-PD-L1 monoclonal antibody-VEGFR1 fusion Protein. Nonclinical data both in vitro and vivo have shown high-affinity binding to targets as well the inhibition of tumor growth animal models. Here, we present preliminary safety efficacy from dose escalation phase I study HB0025. Methods: Eligible patients(pts) were ≥18 years old (ECOG PS 0–1) who had advanced solid tumors (NSCLC, gynecological tumors, digestive system etc.) failed standard...
Objective: This study was conducted to compare the pharmacokinetics, safety and immunogenicity of HOT-1010 with bevacizumab (Avastin®) in Chinese healthy male subjects. Methods: A single-center, randomized, double-blind, single-dose, parallel trial performed 84 subjects who randomly (1:1) received a single intravenous infusion 1 mg/kg or Avastin® for 90 min followed up 85 days. Serum concentrations were analyzed by enzyme-linked immunosorbent assay. Primary pharmacokinetic parameters, C max...
Abstract Background Intravenous thrombolysis (IVT) is a rapid and effective treatment in the early stage of ischemic stroke patients purpose this work to explore significance Hounsfield unit (HU) value Alberta Stroke Program Early CT Score (ASPECTS) for predicting clinical prognosis with middle cerebral artery occlusion (MCAO) treated by IVT. Methods The 84 MCAO IVT were divided into good group (48 cases) poor (36 cases). HU ratio difference calculated from non-contrast computed tomography...
Objective: This study explored the bioequivalence of a proposed biosimilar HOT-3010 vs. its reference product (adalimumab) among healthy Chinese male subjects. The also investigated tolerance, immunogenicity, and pharmacokinetics (PK). Methods: A randomized, double-blind, two-arm, parallel was performed to examine (40 mg) with that adalimumab (Humira ® , AbbVie) as drug. subjects were followed up for 71 days. Results: PK properties exhibited by ( N = 66) 68) groups similar. 90% confidence...