A5102001793- Neural dynamics and brain function
- Skin Protection and Aging
- Dermatology and Skin Diseases
- Contact Dermatitis and Allergies
- Allergic Rhinitis and Sensitization
- Anesthesia and Sedative Agents
- Neuroscience and Neuropharmacology Research
- Functional Brain Connectivity Studies
- Anesthesia and Neurotoxicity Research
- Gut microbiota and health
- RNA modifications and cancer
- Exercise and Physiological Responses
- Nanoparticle-Based Drug Delivery
- Uterine Myomas and Treatments
- Acne and Rosacea Treatments and Effects
- Ultrasound and Hyperthermia Applications
- Thyroid Cancer Diagnosis and Treatment
- Gastrointestinal motility and disorders
- Photoacoustic and Ultrasonic Imaging
- Cardiac Imaging and Diagnostics
- Autoimmune Neurological Disorders and Treatments
- Berberine and alkaloids research
- Chaos-based Image/Signal Encryption
- Cancer, Lipids, and Metabolism
- Ion Channels and Receptors
Nanjing University of Chinese Medicine
2025
Union Hospital
2025
Huazhong University of Science and Technology
2025
Beijing University of Chinese Medicine
2024
Huashan Hospital
2013-2024
Fudan University
2009-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2024
Wenzhou Medical University
2006-2024
Guang’anmen Hospital
2024
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2024
Abstract Background Accumulated evidences have demonstrated that long non-coding RNAs (lncRNAs) are dysregulated and correlate with the pathophysiological basis of malignant tumors. The objective this research is to uncover possible molecular mechanism MACC1-AS1 regarding regulation pancreatic carcinoma (PC) metastasis. Methods lncRNA microarray qRT-PCR were applied identify differentially expressed profile in PC. function role PC assessed via vitro as well vivo assays. Luciferase analyses,...
Abstract Background: Hepatocellular carcinoma (HCC) is the dominant pathological type of primary liver cancer and no effective methods are available for its treatment. Erianin a natural product extracted from Dendrobium, which possesses multiple pharmacological activities, including antioxidative antitumor activity. Objective: To evaluate anti-HCC activities erianin explore underlying mechanism. Methods: MTT assay Crystal Violet staining were used to select non-toxic concentrations...
In this study, we aimed to determine an effective strategy for the synthesis of folate receptor (FR) targeted-nanoparticles (FRNPs). The nanoparticles used as ultrasound contrast agents (UCAs) were composed a liquid core perfluorooctyl bromide (PFOB) liposome and targeted shell chemically conjugated with folic acid (FA) polyethylene glycol (PEG). This was done in order avoid recognition clearance by mononuclear phagocyte system [also known reticuloendothelial (RES)] enhance targeting...
A folate-polyethylene glycol-chitosan derivative was synthesized and its structure characterized. An optimal perfluorooctyl bromide nanocore template obtained via utilizing the ultrasonic emulsification method combining with orthogonal design. The targeted nanoparticles containing shell of ultrasound imaging were prepared successfully by exploiting layer-by-layer self-assembly as contrast agent for ultrasound. Properties novel nanoparticle extensively studied Dynamic Light Scattering...
Ketamine (KET) and isoflurane (ISO) are two widely used general anesthetics, yet their distinct shared neurophysiological mechanisms remain elusive. In this study, we conducted a comparative analysis of KET ISO effects on c-Fos expression across the brain, utilizing hierarchical clustering c-Fos-based functional network to evaluate responses individual brain regions each anesthetic. Our findings demonstrate that significantly activates cortical subcortical arousal-promoting nuclei, with...
Background: Pyroptosis, a cell death process triggered by chemotherapy drugs, has emerged as highly promising mechanism for combating tumors in recent years. As the lead of new natural products play an important role discovery anticancer drugs. Compared to other products, medicine food homologous (MFHNP) exhibit superior safety profile. Among series MFHNP molecular skeletons, this study found that only benzylideneacetophenone (1) could induce cancer pyroptosis. However, anti-cancer activity...
Background Cumulative evidence has suggested that vitamin D deficiency is related with an increased susceptibility to various types of cancers. However, the association between and thyroid cancer (TC) remained be unknown. Thus, there been urgent need for a meta-analysis summarize existing on levels risk TC. Objective This aimed figure out level Methods A systematic search was performed eligible articles TC based PubMed, Embase, Web Science, Cochrane, ClinicalTrials.gov . Outcomes were cases...
Photoallergic contact dermatitis (PACD) is a hypersensitivity reaction that occurs when previously photosensitized exogenous agent comes into with UV radiation. The best method for testing PACD photopatch (PPT).The primary objective of the study was to determine frequency 20 different photoallergens in common usage China during 10-year period.All patients (n = 6153) who had PPTs done between 2005 and 2014 at Department Dermatology Huashan Hospital, Fudan University, were included.A total...
Chronic itch is a common distressing symptom of many diseases, which reduced patient's quality life. The mechanistic study on and screening for new anti-itch drugs require the development pre-clinical animal models. Herein, we established an acute model by intradermal (i.d.) injection low-dose formalin into neck or cheek in mice. In mice, i.d. (0.1–5%) nape evoked robust scratching behavior dose-dependent manner dose–response curves showed inverted “U” shape. I.d. (0.3–0.6%) mice but wiping...
Photoallergic contact dermatitis (PACD) is of importance in a proportion photodermatoses and can be evaluated through photopatch testing (PPT).The objectives this study were to evaluate the results PPT investigate prevalence PACD reactions different photoallergens Chinese patients at Department Dermatology Huashan Hospital Fudan University during 7-year period.A retrospective was conducted. During 7 years, 4957 attending for investigation suspected tested according European consensus...
Chronic actinic dermatitis (CAD) is a spectrum of diseases with chronic photosensitivity occurring mostly among middle-aged and older men. We seek to explore the characteristics pathogenesis CAD Chinese population.The medical records 488 cases diagnosed by phototesting at Huashan Hospital, Fudan University from January 2014 December 2018 were analyzed retrospectively.Among patients, 344 male 144 female. 84.8% over 40 years old age onset, while remaining an early onset had prevalence atopic...
Benz[e]indenes (BIs) are tricyclic molecules that can be envisioned as steroids without an A-ring. Because certain known to alter gamma-aminobutyric acid (GABA) responses in central neurons, we examined the effects of a substituted BI resembling 3 alpha-hydroxy-5 alpha-pregnan-20-one (3 alpha-OH-DHP) on GABA-gated chloride currents cultured postnatal rat hippocampal neurons. The compound, BI-1, reversibly potentiated GABA at concentrations > 10 nM, with EC50 value 0.2 microM. BI-1 increased...
Few studies have been conducted in chronic actinic dermatitis (CAD) treated with narrowband ultraviolet B (NB UVB) phototherapy, especially Asian patients. We aim to evaluate the efficacy and safety of NB UVB phototherapy Chinese patients CAD. 19 CAD Fitzpatrick skin phototype IV received spring treatments were given 3 times weekly incremental dose maintenance therapy was twice for 3-4 weeks. The mean initial, endpoint, cumulative 0.08, 0.33, 6.0 J/cm2 , respectively. Patients totally 27...
ABSTRACTSensitizing strategy is required to improve the clinical management of glioblastoma (GBM). 5-Lipoxygenase (Alox5) has been recently garnered attention due its pro-carcinogenic roles in various cancers. This study demonstrates that Alox5 overexpressed GBM but not normal neuronal tissues. depletion inhibits growth cells, both bulky and stem-like populations, enhances anti-cancer effects temozolomide. The mechanism behind this involves a decrease β-catenin level activity upon depletion....
Summary Purpose To quantitatively assess the effect of formal sun protection education on exposure habits and quality life in photosensitive patients. Methods Patients with chronic actinic dermatitis ( CAD ) or polymorphous light eruption PLE were randomized to either intervention control group. General advice about broad‐spectrum sunscreen provided all participants. The group was given two additional intensive instruction classes at beginning spring then summer. At baseline 12 months, each...
To investigate the feasibility of anti-mucin 1 (anti-MUC1/CD227) antibody in fluorescent imaging ovarian cancer, CD227 and a control IgG were labeled with near-infrared dye [Cy5.5-N-hydroxysuccinimide (NHS)] green (fluorescein-NHS). In vivo fluorescence images obtained at 4, 12 36 h after injection probes into OVCAR3 tumor-bearing mice. The tumor to background ratios calculated for both probes. Ex following sacrifice h. After conjugation Cy5.5 fluorescein, dual-color probe (Ab-FL-Cy5.5)...
Intestinal permeability and stress have been implicated in the pathophysiology of irritable bowel syndrome (IBS). Cytokeratin 8 (CK8), for first time, has shown to mediate corticotropin-releasing factor (CRF)-induced changes intestinal animal models IBS. In this study, we investigated regulatory effects CRF on human epithelial cells through CK8-mediated tight junction.The expression levels receptor 1 (CRFR1) 2 (CRFR2) HT29 cell surface were determined by immunofluorescence, RT-PCR, Western...