A5100680664- Graphene and Nanomaterials Applications
- Bone Tissue Engineering Materials
- Nanoplatforms for cancer theranostics
- Extracellular vesicles in disease
- Nanoparticle-Based Drug Delivery
- Ultrasound and Hyperthermia Applications
- 3D Printing in Biomedical Research
- Electrospun Nanofibers in Biomedical Applications
- Photoacoustic and Ultrasonic Imaging
- Advanced Nanomaterials in Catalysis
- High Entropy Alloys Studies
- Metal-Organic Frameworks: Synthesis and Applications
- Advanced Chemical Physics Studies
- RNA Interference and Gene Delivery
- Osteoarthritis Treatment and Mechanisms
- Silk-based biomaterials and applications
- Tissue Engineering and Regenerative Medicine
- Lignin and Wood Chemistry
- Advanced biosensing and bioanalysis techniques
- Advanced Polymer Synthesis and Characterization
- Thyroid Cancer Diagnosis and Treatment
- Ultrasound and Cavitation Phenomena
- Orthopedic Infections and Treatments
- Thermoregulation and physiological responses
- biodegradable polymer synthesis and properties
Ningbo First Hospital
2016-2025
Ningbo University
2016-2025
Huazhong University of Science and Technology
2009-2025
National Medical Products Administration
2024-2025
University of Jinan
2023-2024
Zhejiang University
2016
Pittsburgh Quantum Institute
2016
University of Pittsburgh
2016
Northeast Forestry University
2014
Large segmental bone regeneration remains a great challenge due to the lack of vascularization in newly formed bone. Conventional strategies primarily combine scaffolds with seed cells and growth factors modulate osteogenesis angiogenesis. Nevertheless, cell-based therapies have some intrinsic issues regarding immunogenicity, tumorigenesis, bioactivity off-the-shelf transplantation. Exosomes are nano-sized (50-200 nm) extracellular vesicles complex composition proteins, nucleic acids lipids,...
We report a biodegradable synthetic material that opens door to repair damaged tissue via boosting cellular energy metabolism.
The encapsulation of hydrophilic drug in polymeric nanoparticles with high loading remains a challenge due to the rapid penetration external aqueous phase. In order improve efficiency daunorubicin (DNR) poly(D,L-lactic-co-glycolic acid (PLGA) and poly(D,L-lactic acid) (PDLLA) nanoparticles, we fabricated series DNR-loaded using modified double-emulsion solvent evaporation/diffusion method, which introduced partially water-soluble organic into particle formation. influence various preparation...
Abstract Recently, neurological disorders have led to a growing global burden of fatalities and disabilities. The limited capacity for natural self‐regeneration poses significant challenge in repairing nervous system injuries, which is closely related the complex microenvironment nonregenerative nature neurons. Metal–organic frameworks (MOFs), with their distinctive structure properties including high surface area, porosity, tunability, stimuli‐responsive behavior, biocompatibility,...
Cartilage regeneration relies on adequate and continuous bioenergy supply to facilitate cellular differentiation extracellular matrix synthesis. Chondrocytes frequently undergo energy stress under pathological conditions, characterized by disrupted metabolism reduced adenosine triphosphate (ATP) levels. However, there has limited progress in modulating for cartilage thus far. Here, we developed bioenergetic-active exosomes (Suc-EXO) promote homeostasis maintenance. Suc-EXO exhibited a...
This study aimed to explore the efficacy of Prognostic Nutritional Index (PNI), Controlling Status (CONUT), and Risk (NRI) in predicting postthrombotic syndrome (PTS) patients with lower extremity deep vein thrombosis (DVT) based on peripheral blood samples. We reviewed analyzed DVT our hospital from June 2020 December 2023. The receiver operating characteristic (ROC) curve identified best nutritional scoring system for a logistic regression model. Restricted cubic spline (RCS) analysis...
Trauma or inflammation-caused cartilage injury leads to joint dysfunction and pain. Exogenous hyaluronic acid (HA) injection is a well-established treatment, but it has short duration in vivo requires multiple injections. Here, new strategy for situ reprogramming chondrocytes continuously produce endogenous high molecular weight HA developed. This involves pH-responsive engineered exosome decorated with vesicular stomatitis virus glycoprotein (VSV-G) hyaluronan synthase type 2 (HAS2). Such...
Current major obstacles for translating the nanoparticle (NP) morphology-related function into therapeutic purposes come from challenges in understanding mechanisms that determine cell lineage commitment and constructing a NP-based 3D functional structure, few studies have successfully demonstrated clear evidence of regulating vivo tissue regeneration by NP morphology so far. Here, we show geometry can be harnessed to mediate bone rat cranial defect model. We synthesized hydroxyapatite NPs...
Sonothrombolysis with microbubbles can enhance the dissolution of thrombus through cavitation effect under ultrasound irradiation. However, detailed mechanism thrombolysis microscaled or nanoscaled bubbles is still not so clear. This study compared thrombolytic capacity cRGD-targeted nontargeted different particle sizes combined urokinase (UK). The size (Mbs Mbs-cRGD) was mostly approximately 3 μm, while (Nbs Nbs-cRGD) were mainly around 220 nm. In vitro testing performed on an...
In this study, we aimed to determine an effective strategy for the synthesis of folate receptor (FR) targeted-nanoparticles (FRNPs). The nanoparticles used as ultrasound contrast agents (UCAs) were composed a liquid core perfluorooctyl bromide (PFOB) liposome and targeted shell chemically conjugated with folic acid (FA) polyethylene glycol (PEG). This was done in order avoid recognition clearance by mononuclear phagocyte system [also known reticuloendothelial (RES)] enhance targeting...
Abstract Skin defect is common in daily life, but repairing large skin defects remains a challenge. Using biomaterials to deliver biochemical or physical factors promote tissue regeneration of great significance for accelerating wound healing. Specific surface micropatterns on could affect cell behavior and regeneration. However, few studies have focused the construction healing with their role In present study, gelatin–polycaprolactone/silk fibroin composite membranes different were...
Immobilizing osteogenic growth peptide with and without fibronectin on a titanium surface: effects of loading methods mesenchymal stem cell differentiation Cen Chen,1,2 Han Li,1 Xiangdong Kong,2 Sheng-Min Zhang,1 In-Seop Lee2,3 1Advanced Biomaterials Tissue Engineering Center, Huazhong University Science Technology, Wuhan, People's Republic China; 2Bio-X College Life Sciences, Zhejiang Sci-Tech University, Hangzhou, 3Institute Natural Yonsei Seoul, Korea Abstract: In this study, to improve...
A folate-polyethylene glycol-chitosan derivative was synthesized and its structure characterized. An optimal perfluorooctyl bromide nanocore template obtained via utilizing the ultrasonic emulsification method combining with orthogonal design. The targeted nanoparticles containing shell of ultrasound imaging were prepared successfully by exploiting layer-by-layer self-assembly as contrast agent for ultrasound. Properties novel nanoparticle extensively studied Dynamic Light Scattering...
We investigate the electronic structure and photoexcitation dynamics of alkali atoms (Rb Cs) chemisorbed on transition-metal Ru(0001) single-crystal surface by angle- time-resolved multiphoton photoemission. Three- four-photon photoemission (3PP 4PP) spectroscopic features due to $\ensuremath{\sigma}$ $\ensuremath{\pi}$ resonances arising from $ns$ $np$ states free are observed $\ensuremath{\sim}2$ eV below vacuum level in zero-coverage limit. As coverage is increased a maximum 0.02...