Tri-n-butylphosphine (TBP) has been shown to effectively catalyze an air-insensitive disulfide metathesis reaction under alkaline conditions at room temperature. A cross-linked polysulfide containing the phosphine exhibited repeated autonomous self-healing resulting in restoration of tensile strength as a result dynamic exchange bonds. Interestingly, can also be reshaped and reprocessed temperature via TBP-mediated reshuffling macromolecular networks. The mechanical properties ability...

The prevalence of drug allergies documented in electronic health records (EHRs) large patient populations is understudied.We aimed to describe the common and characteristics EHRs a healthcare network over last two decades.Drug allergy data were obtained from patients who visited tertiary care hospitals Boston 1990 2013. each class was calculated compared by sex race/ethnicity. number per frequency having 1, 2, 3…, or 10+ reported. We also conducted trend analysis comparing proportion total...

Possible types of, and formation mechanisms for, mesocrystals are summarized. Mesocrystals a new class of solid materials, which can be regarded as assemblies crystallographically oriented nanocrystals. have high crystallinity well porosity, making them promising substitutes for single-crystalline and/or porous polycrystalline materials in many applications such catalysis, sensing, solar-energy conversion.

When illuminated by near-UV light, titanium dioxide (TiO2) exhibits excellent bactericidal activity. However, there exist some different mechanisms for cell killing via photocatalysis. In the present study, photocatalytically mechanism of TiO2 thin films was investigated atomic force microscopy (AFM) in conjugation with other techniques. The decomposition process wall and membrane directly observed AFM first time. resultant change permeability confirmed potassium ion (K+) leakage. Quantum...

Mesocrystals are a new class of nanostructured solid materials, which most often made crystallographically oriented nanoparticles. Structural features, properties, and possible applications mesocrystals summarized in this paper. Due to their unique structural features the resulting physical physicochemical expected play significant role improving performance materials many applications. These as diverse heterogeneous photocatalysts, electrodes, optoelectronics, biomedical hard templates,...

Uniform mesocrystals of TiO2 (anatase) have been prepared from NH4TiOF3. NH4TiOF3 was synthesized an aqueous solution containing (NH4)2TiF6 and H3BO3 in the presence a nonionic surfactant Brij 56, 58, or 700, at low temperatures. The exterior shapes can be tuned by adjusting reagent concentration, reaction time, temperature, rate stirring. formation proceeds via self-assembly process involving nonclassical crystal growth. By sintering air 450 °C, washing with ambient temperatures, converted...

Crosslinked polyacrylate is self-healed and reprocessed through rearrangement of networks based on catalyst-free dynamic exchange aromatic Schiff base bonds.

Novel poly(ethylene oxide)-graft-doxorubicin (PEO-g-DOX) prodrugs with DOX covalently conjugated to PEO via a pH-sensitive hydrazone bond were developed. PEO-g-DOX conjugates could be readily prepared in the following steps: (i) anionic ring-opening copolymerization of ethylene oxide (EO) and allyl glycidyl ether (AGE) afforded functional controlled molecular weights, low polydispersities, multiple pendant double bonds (PEO-g-allyl); (ii) conjugation PEO-g-allyl methyl mercaptoacetate,...

A nanocomposite of SnS2 nanoparticles with reduced graphene oxide (SnS2@RGO) had been successfully synthesized as a substitute conventional Pt counter electrode (CE) in dye-sensitized solar cell (DSSC) system. The were uniformly dispersed onto sheets, which formed nanosized composite effectiveness this exhibited remarkable electrocatalytic properties upon reducing the triiodide, owning to synergistic effects on sheet and improved conductivity. Consequently, DSSC equipped SnS2@RGO CE achieved...

Hydroxyapatite (HA) doped with trace elements has attracted much attention recently owing to its excellent biological functions. Herein, we use a facile co-precipitation method incorporate selenium into HA by adding sodium selenite during synthesis. The obtained selenium-substituted products are needle-like nanoparticles which have size and crystallinity that similar those of the pure (HANs) when content is low. HANs found ability induce apoptosis osteosarcoma cells, anti-tumour effects...

Analyzing of volatile organic compounds (VOCs) is important in rice quality control and breeding aromatic cultivars. This study utilized HS-GC–IMS, known for its simplicity, high sensitivity, low cost, to analyze VOCs 59 6 non-aromatic The intensity each cultivar was determined by artificial sensory evaluation, thus the correlation between evaluation scores VOC peak volumes explored. A total 77 were identified, with cultivars exhibiting prevalent short-chain aliphatic aldehydes, alcohols,...

The encapsulation of hydrophilic drug in polymeric nanoparticles with high loading remains a challenge due to the rapid penetration external aqueous phase. In order improve efficiency daunorubicin (DNR) poly(D,L-lactic-co-glycolic acid (PLGA) and poly(D,L-lactic acid) (PDLLA) nanoparticles, we fabricated series DNR-loaded using modified double-emulsion solvent evaporation/diffusion method, which introduced partially water-soluble organic into particle formation. influence various preparation...

For the first time, we describe a simple, room-temperature surfactant-mediated route to inorganic mesocrystals of NH(4)TiOF(3) and their remarkable topotaxial conversion by washing or annealing TiO(2) as anatase mesocrystals.

Background: Although mTOR has long been regarded as a promising target for cancer treatment, the efficacy of inhibitors in most clinical trials rather limited. Nevertheless, their favorable safety profile opened up opportunities drug repurposing, even potential applications across various diseases remain largely unexplored. Methods: We performed an MR-PheWAS analysis 1431 phenotypes to explore repurposing opportunities. analyzed GWAS data 452 plasma metabolites, 731 immune traits, and 412...

This study aimed to develop a novel adsorbent, Zn2+ -loaded hexanediamine-chitosan (HDA-CS) beads, for the selective removal of human testosterone from plasma. The preparation involved synthesizing chitosan modifying them with hexanediamine enhance adsorption capacity and subsequently loading zinc ions. effects HDA spacer, concentration, time on percentage were systematically investigated through series experiments. Results indicated that -HDA-CS beads achieved maximum approximately 35%...

This study aims to investigate therapeutic effects and involved molecular mechanisms of Banxia Xiexin Decoction (BXD) in reducing gastrointestinal complications associated with sepsis. Sepsis is a common critical illness that threatens patient survival costs society lot. syndrome prominent cause death ICUs due its high mortality rate, which exceeds 30% after 28 days 35.5% 90 days. remains major medical challenge despite 20%-30% drop fatality rates better understanding physiological...

A novel bi-template induced co-assembly method was employed to fabricate biomimetic bone substitute materials, collagen (COL)-fibroin/hydroxyapatite (COL-SF/HA) composite by using a combination of Type I COL and silk fibroin (SF) molecular templates. As control, COL/HA SF/HA composites were also synthesized via single-template assembly technology. The structure morphology the resulting investigated X-ray diffractometer, Fourier transform infrared spectra, transmission electron microscope,...