A5100680669- Bone Tissue Engineering Materials
- Extracellular vesicles in disease
- Polymer Surface Interaction Studies
- MicroRNA in disease regulation
- Advanced Photocatalysis Techniques
- Electrophoretic Deposition in Materials Science
- Immune cells in cancer
- Dental Implant Techniques and Outcomes
- Diatoms and Algae Research
- Nanoplatforms for cancer theranostics
- Ocular Diseases and Behçet’s Syndrome
- Diet and metabolism studies
- Obstructive Sleep Apnea Research
- Systemic Lupus Erythematosus Research
- Cellular Mechanics and Interactions
- Pain Management and Placebo Effect
- Dental materials and restorations
- 3D Printing in Biomedical Research
- Bone and Dental Protein Studies
- Osteoarthritis Treatment and Mechanisms
- Cancer Cells and Metastasis
- Otitis Media and Relapsing Polychondritis
- Electrospun Nanofibers in Biomedical Applications
- Silk-based biomaterials and applications
- Proteoglycans and glycosaminoglycans research
Huazhong University of Science and Technology
2015-2025
New Technology (Israel)
2023
The immune microenvironment induced by biomaterials played vital roles in bone regeneration. Hydroxyapatite (HA) and its ion-substituted derivates represent a large class of core inorganic materials for tissue engineering. Although ion substitution was proved to be potent way grant HA more biological functions, few studies focused on the immunomodulatory properties ion-doped HA. Herein, explore potential osteoimmunomodulatory effects HA, zinc strontium co-assembled into through collagen...
Abstract Cancer recurrence and metastasis after surgical resection is a vital reason of treatment failure. The modification immune cells through implanted biomaterials promising postoperative immunotherapy. Herein, an injectable hydrogel scaffold loaded with engineered exosome mimetics that in vivo recruits programs endogenous macrophages into M1 binding anti‐CD47 antibody (M1‐aCD47 macrophages) for cancer immunotherapy developed. Briefly, macrophages‐derived co‐modified vesicular stomatitis...
Angiogenesis plays a pivotal role in tissue development and regeneration, but few safe efficient pro-angiogenic factors are available for long-term clinical therapy. Although stem cell-derived exosomes exhibit excellent biocompatibility considerable capacity, their low yield extremely limits potential. Exosome-mimetics (EMs) employ similar features to can be produced higher yield. In this study, the HY-EMs were enhance vitro vivo ability from hypoxia-preconditioned bone marrow mesenchymal...
Trauma or inflammation-caused cartilage injury leads to joint dysfunction and pain. Exogenous hyaluronic acid (HA) injection is a well-established treatment, but it has short duration in vivo requires multiple injections. Here, new strategy for situ reprogramming chondrocytes continuously produce endogenous high molecular weight HA developed. This involves pH-responsive engineered exosome decorated with vesicular stomatitis virus glycoprotein (VSV-G) hyaluronan synthase type 2 (HAS2). Such...
Vogt-Koyanagi-Harada (VKH) is a multisystemic autoimmune disorder characterized by bilateral panuveitis frequently accompanied neurologic manifestations. While metabolic dysregulation increasingly recognized in the context of diseases, role specific metabolites VKH disease remains unexplored. Non-targeted and targeted metabolomics analysis, phospho-antibody array, proteome microarray, surface plasmon resonance, molecular simulation were used to identify target OA. We investigated profile...
Zinc substituted hydroxyapatite/silk fibroin composite coatings were deposited on titanium substrates at room temperature by electrophoretic deposition. Microscopic characterization of the synthesized nanoparticles revealed that particle size ranged 50–200 nm, which increased a little after zinc substitution. The obtained maintained phase hydroxyapatite and they could induce fast apatite formation in simulated body fluid, indicating high bone activity. cell culturing results showed...