A5012721483- 3D Printing in Biomedical Research
- Wound Healing and Treatments
- Hydrogels: synthesis, properties, applications
- Advanced Neural Network Applications
- Cell Adhesion Molecules Research
- Extracellular vesicles in disease
- Surgical Sutures and Adhesives
- Bacterial biofilms and quorum sensing
- Advanced Image and Video Retrieval Techniques
- Electrospun Nanofibers in Biomedical Applications
- Dielectric materials and actuators
- Advanced Sensor and Energy Harvesting Materials
- Osteoarthritis Treatment and Mechanisms
- Cellular Mechanics and Interactions
- Additive Manufacturing and 3D Printing Technologies
- Antimicrobial Peptides and Activities
- Antimicrobial agents and applications
- Bone and Dental Protein Studies
- Mitochondrial Function and Pathology
- Burn Injury Management and Outcomes
- Additive Manufacturing Materials and Processes
- Pressure Ulcer Prevention and Management
- Infrared Target Detection Methodologies
- Oral microbiology and periodontitis research
- Proteoglycans and glycosaminoglycans research
Huazhong University of Science and Technology
2021-2025
The University of Texas at Austin
2018-2024
Fujian Agriculture and Forestry University
2022-2024
Northwestern Polytechnical University
2020
Texas A&M University
2019
University of Pennsylvania
2019
Tsinghua University
2015
Indiana University School of Medicine
2015
The immune microenvironment induced by biomaterials played vital roles in bone regeneration. Hydroxyapatite (HA) and its ion-substituted derivates represent a large class of core inorganic materials for tissue engineering. Although ion substitution was proved to be potent way grant HA more biological functions, few studies focused on the immunomodulatory properties ion-doped HA. Herein, explore potential osteoimmunomodulatory effects HA, zinc strontium co-assembled into through collagen...
Abstract A major challenge in chronic wound treatment is maintaining an appropriate moisture balance throughout the healing process. Wound dehydration hinders due to impeded molecule transport and cell migration with associated tissue necrosis. In contrast, wounds that produce excess fluid contain high levels of reactive oxygen species matrix metalloproteases impede recruitment, extracellular reconstruction, angiogenesis. Dressings are currently selected based on relative amount exudate no...
Drug delivery to solid tumors is hindered by hydrostatic and physical barriers that limit the penetration of nanocarriers into tumor tissue. When exploiting enhanced permeability retention (EPR) effect for passive targeting nanocarriers, increased interstitial fluid pressure dense extracellular matrix in limits distribution perivascular regions. Previous strategies have shown magnetophoresis enhances accumulation nanoparticles tumors. However, because magnetic fields fall off rapidly with...
Object detection in scenes captured by unmanned aerial vehicles (UAV) is an active research area. However, the performance and efficiency of current small object models for UAV images are far from reaching desired level. The inherent limitations features objects themselves inconsistency contextual information feature maps lead to a degradation final performance. In this letter, improve image detection, we propose multi-scale optimization network, named MFO-Net. We have designed three crucial...
Cartilage regeneration relies on adequate and continuous bioenergy supply to facilitate cellular differentiation extracellular matrix synthesis. Chondrocytes frequently undergo energy stress under pathological conditions, characterized by disrupted metabolism reduced adenosine triphosphate (ATP) levels. However, there has limited progress in modulating for cartilage thus far. Here, we developed bioenergetic-active exosomes (Suc-EXO) promote homeostasis maintenance. Suc-EXO exhibited a...
Trauma or inflammation-caused cartilage injury leads to joint dysfunction and pain. Exogenous hyaluronic acid (HA) injection is a well-established treatment, but it has short duration in vivo requires multiple injections. Here, new strategy for situ reprogramming chondrocytes continuously produce endogenous high molecular weight HA developed. This involves pH-responsive engineered exosome decorated with vesicular stomatitis virus glycoprotein (VSV-G) hyaluronan synthase type 2 (HAS2). Such...
Chronic wounds are projected to reach epidemic proportions worldwide because of the aging population and increasing incidence diabetes. Despite extensive research, infection remains one leading sources complications in chronic wounds, resulting improper healing, biofilm formation, lower extremity amputation. To address limitations standard treatments, we have developed a hydrogel wound dressing with self-tuning moisture control that incorporates novel antimicrobial agent eliminate prevent...
Abstract Stem cell therapy and skin substitutes address the stalled healing of chronic wounds in order to promote wound closure; however, high cost regulatory hurdles these treatments limit patient access. A low‐cost method induce bioactive has potential substantially improve care prevent wound‐induced limb loss. previous study reported that factors derived from apoptotic‐like mesenchymal stem cells (MSCs) demonstrated anti‐inflammatory proangiogenic effects improved ischemic muscle...
Abstract A new methodology is presented for generating hydrocolloid inks, emulsions of hydrogel precursor solutions with mineral oil, solid freeform fabrication porous scaffolds. These inks exhibit viscoplastic behavior and rapid photopolymerization that permit high fidelity printing complex geometries. Hydrocolloid based on poly(ethylene glycol) diacrylate are utilized to fabricate custom scaffolds using open source 3D software customized paste extruder cure‐on‐dispense capabilities....
A platform based on the ECIS technique was constructed for analyzing heat-cell interactions and further<italic>in vitro</italic>hyperthermia studies.
This study employed an in-depth analysis of the landscape spatial suitability, experience and its impact on natural history heritage sites in Quanzhou City. was achieved by combining machine learning models hotspot methods such as BERT, HRnet, Matlab LightGBM. The intrinsic correlation between perception tourists' emotions about suitability City explored. different elements sentiments towards landscapes at historical further derived through SHAP interpretability analysis. Based this...
Abstract The high incidence of osteomyelitis associated with critical‐sized bone defects raises clinical challenges in fracture healing. Clinical use antibiotic‐loaded cement as an adjunct therapy is limited by incompatibility many antimicrobials, sub‐optimal release kinetics, and requirement surgical removal. Furthermore, overuse antibiotics can lead to bacterial modifications that increase efflux, decrease binding, or cause inactivation the antibiotics. Herein, we compared efficacy gallium...
The growth of bacterial biofilms on implanted medical devices causes harmful infections and device failure. Biofilm development initiates when bacteria attach to sense a surface. For the common nosocomial pathogen Pseudomonas aeruginosa many others, transition biofilm phenotype is controlled by intracellular signal second messenger cyclic-di-GMP (c-di-GMP). It not known how biomedical materials might be adjusted impede c-di-GMP signalling, there are few extant methods for conducting such...
Abstract Conductive hydrogels have gained interest in biomedical applications and soft electronics. To tackle the challenge of ionic falling short desired mechanical properties previous studies, our investigation aimed to understand pivotal structural factors that impact conductivity behavior polyethylene glycol (PEG)-based with conductivity. Polyether urethane diacrylamide (PEUDAm), a functionalized long-chain macromer based on PEG, was used synthesize conferred by incorporating ions into...