A5032028380- Cancer-related molecular mechanisms research
- Complement system in diseases
- Cardiovascular Function and Risk Factors
- MicroRNA in disease regulation
- Lung Cancer Treatments and Mutations
- Circular RNAs in diseases
- Smart Grid Energy Management
- Cardiac Imaging and Diagnostics
- Microgrid Control and Optimization
- PI3K/AKT/mTOR signaling in cancer
- Electric Vehicles and Infrastructure
- Cancer Immunotherapy and Biomarkers
- Brain Metastases and Treatment
- Pregnancy and preeclampsia studies
- RNA modifications and cancer
- Metallic Glasses and Amorphous Alloys
- Cancer Genomics and Diagnostics
- Cardiac electrophysiology and arrhythmias
- Autophagy in Disease and Therapy
- Immunotherapy and Immune Responses
- Natural Compounds in Disease Treatment
- Transplantation: Methods and Outcomes
- Cardiovascular and Diving-Related Complications
- Material Dynamics and Properties
- Cardiovascular Syncope and Autonomic Disorders
Jinan University
2021-2025
Southern University of Science and Technology
2015-2025
Heilongjiang Provincial Academy of Agricultural Sciences
2022-2024
Northern Jiangsu People's Hospital
2015-2024
Yangzhou University
2017-2024
Zhejiang University of Technology
2024
Yunnan Observatories
2024
Gannan Medical University
2023
East China Normal University
2023
Affiliated Hospital of Hebei University
2023
Abstract Bioavailability and therapeutic efficacy of soluble Crry, a mouse inhibitor all complement activation pathways, is significantly enhanced when linked to fragment receptor 2 (CR2), that targets C3 products. In this study, we characterize alternative pathway-specific inhibitors consisting single or dimeric N-terminal region factor H (fH; short consensus repeats 1–5) the same CR2 (CR2-fH CR2-fHfH). Both CR2-fH CR2-fHfH were highly effective at inhibiting pathway in vitro demonstrated...
Human amnion-derived mesenchymal stem cells (AD-MSCs) have been reported as a promising effective treatment to repair tissue. Trophoblast dysfunction during pregnancy is significantly involved in the pathogenesis of preeclampsia (PE). To understand how AD-MSCs regulated trophoblast function, we treated trophoblasts with AD-MSC-derived exosomes under hypoxic conditions. The markedly enhanced proliferation and autophagy. Furthermore, significant decrease EZH2 levels inactivation mTOR signaling...
The rising prevalence of chronic kidney disease (CKD) has emerged as a global public health concern, posing significant threat to human health. This study aimed assess changes in left atrial (LA) function patients with CKD ventricular hypertrophy (LVH) using two-dimensional speckle-tracking echocardiography (2D-STE) and investigate the independent correlations between baseline parameters LA strain rate. We conducted prospective that included diagnosed at Shenzhen People's Hospital November...
Speculative sampling has emerged as an important technique for accelerating the auto-regressive generation process of large language models (LLMs) by utilizing a draft-then-verify mechanism to produce multiple tokens per forward pass. While state-of-the-art speculative methods use only single layer and modeling (LM) head draft model achieve impressive compression, their efficiency gains are substantially reduced large-vocabulary LLMs, such Llama-3-8B with vocabulary 128k tokens. To address...
Accurate numerical weather prediction is a prerequisite for disaster prevention and mitigation. Based on the ocean-atmosphere-wave coupling forecasting model developed by our team, artificial intelligence technology introduced to correct bias, addressing systematic forecast error inherent in models, further enhancing accuracy reliability of products. This study aims establish bias correction products integrate multi-source geographic information, such as elevation, land cover, soil type,...
Demand response (DR) is proven effective in reducing costs and increasing resilience for microgrids. In addition to fixed un-adjustable public loads, loads that can participate demand are mainly divided into industrial, commercial, residential loads. many countries regions, the electricity price load baseline of these types vary significantly. addition, different users have sensitivity methods participation DR. To address issues, with implementation an incentive-compatible bidding mechanism,...
To investigate differences in the prevalence of left ventricular (LV) and atrial (LA) remodelling hypertensive patients using various thresholds defined by international guidelines data from Echocardiographic Measurements Normal Chinese Adults (EMINCA) study different indexation methods. LV mass (LVM), relative wall thickness, LA volume (LAV) were measured 2D echocardiography 612 healthy volunteers selected EMINCA population 306 adult with hypertension who age- gender-matched propensity...
Incentive-based demand response (IBDR) was considered as a feasible option to solve the sudden shortage of distributed energy resource in microgrid. However, current IBDR policies and strategies are not directly applicable residents due many defects. To this end, versatile hierarchical strategy is proposed article. ensure effectiveness load reduction on critical period, clustering with (DR) levels decision-making algorithm obtain reliable estimation DR quantity. enhance system reliability,...
Whole-brain radiotherapy (WBRT) is the mainstay of therapy in treating cancer patients with brain metastases, but unfortunately, it might also lead to decline neurocognitive function. This study aims investigate preservation long-term function after hippocampal avoidance whole-brain (HA-WBRT). Retrospectively, 47 diagnosed metastases non-small cell lung (NSCLC) between 2015-01-01 and 2017-12-31 at Department Oncology, XXX Hospital were selected divided into 2 groups. Group A (n = 27)...
Comparative analysis between Zr-rich Zr50Cu45Al5 and Cu-rich Cu50Zr45Al5 metallic glasses (MGs) is extensively performed to locate the key structural motifs accounting for their difference of glass forming ability. Here we adopt ab initio molecular dynamics simulations investigate local atomic structures MGs. A high content icosahedral-related (full distorted) orders was found in both samples, while MG full icosahedrons ⟨0, 0, 12, 0⟩ dominant, one distorted icosahedral orders, especially 2,...
In this study, we aimed to develop a prediction model assist surgeons in choosing an appropriate surgical approach for mitral valve disease patients. We retrospectively analyzed total of 143 patients who underwent surgery disease. The XGBoost algorithm was used establish predictive decide (mitral repair or replacement) based on the echocardiographic features apparatus, such as leaflets, annulus, and sub-valvular structures. results showed that accuracy 81.09% predicting patient's...
We investigated the application value of no-invasive myocardial work in evaluating left ventricular (LV) function patients with hyperthyroidism.Sixty-five an initial hyperthyroidism diagnosis were sorted into tachycardia (group TH1, n=31) and without TH2, n=34) groups. Thirty healthy participants served as control group CON). LV strain parameters evaluated at rest. Each parameter's identifying damage was analyzed using receiver operating characteristic curves. The correlation global...
Abstract Objectives The study aimed to investigate the protective effects of dexmedetomidine (DEX) on renal injury caused by acute stress in rats and explore pathways DEX rat kidneys terms oxidative stress. Methods An restraint model was utilized, where were restrained for 3 hours after a 15-minute swim. Biochemical tests histopathological sections conducted evaluate function, along with measurement related pathway proteins. Key findings open-field experiments validated successful...
Extensive analysis has been performed to understand the key structural motifs accounting for difference in glass forming ability Zr-Cu and Zr-Ni binary alloy systems. Here, reliable atomic structure models of Zr2CuxNi1−x (x = 0, 0.5, 1) are constructed using combination X-ray diffraction experiments, ab initio molecular dynamics simulations a constrained reverse Monte Carlo method. We observe systematic variation interatomic distance different pairs with respect composition. The ideal...
Purpose . Metabolic syndrome (MetS) is associated with chronic stress. miR-18a-5p and miR-22-3p are two miRNAs which can target the glucocorticoid receptor. This study looked at changes in metabolic parameters predictive value of peripheral blood mononuclear cells (PBMCs) to stress-associated miRNA ratios as new indicators subjects without MetS southern China. Patients Methods There were 81 participants (39 42 MetS) this cross-sectional study. The potential filtrated GEO database. expression...
(1) Objective: To evaluate myocardial injury by observing the different parameters of global work (MW) left ventricular pressure-strain loop (PSL) analysis in patients with chronic kidney disease (CKD). (2) Methods: According to mass index, study CKD were further divided into two groups: normal group (CKDN-LVH, 59) and hypertrophy (CKDLVH, 46). Thirty-three healthy controls (CON) matched age sex recruited. The routine ultrasonic obtained TTE, strain index MW dynamic image offline analysis....
The aim of the present study was to determine expression rho-associated coiled-coil-containing protein kinase 1 (ROCK1) and phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit α (PIK3CA) in nasopharyngeal carcinoma (NPC), assess association between these proteins clinicopathological features NPC. ROCK1 PIK3CA expressions were assessed a tissue microarray sections prepared from tumors 81 patients with NPC using immunohistochemistry. Western blot analysis used detect NP69 5-8F...
The relationship between microRNA-1 (miR-1) expression and prognosis has not been reported in hepatocellular carcinoma (HCC). present study aimed to explore the clinicopathological significance prognostic role of miR-1 HCC.The levels were quantified using real-time quantitative PCR (q-PCR) 40 surgically resected HCC samples matched adjacent non-cancerous tissues.MiR-1 was significantly downregulated compared with tissues. Aberrant correlated gender, hepatitis B virus surface antigen (HBsAg),...